Heterodimerization of Endothelin-converting Enzyme-1 Isoforms Regulates the Subcellular Distribution of This Metalloprotease

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.

1994 • 1,631 citations

HMEC-1: Establishment of an Immortalized Human Microvascular Endothelial Cell Line

1992 • 1,258 citations

Rab7: A Key to Lysosome Biogenesis

2000 • 1,038 citations

Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1

1994 • 1,002 citations

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

1994 • 1,000 citations

Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons

1994 • 934 citations

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

1994 • 932 citations

Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice

1998 • 643 citations

Endothelin-converting Enzyme-2 Is a Membrane-bound, Phosphoramidon-sensitive Metalloprotease with Acidic pH Optimum

1995 • 496 citations

Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.

1994 • 494 citations

Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene

1998 • 488 citations

Endothelin as a regulator of cardiovascular function in health and disease

1998 • 365 citations

Targeting of membrane proteins to endosomes and lysosomes

1994 • 304 citations

Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells

1994 • 291 citations

The dynamins: Redundant or distinct functions for an expanding family of related GTPases?

1997 • 286 citations

Inhibition of a reductive function of the plasma membrane by bacitracin and antibodies against protein disulfide-isomerase.

1993 • 235 citations

Organization of the Gene Encoding the Human Endothelin-converting Enzyme (ECE-1)

1995 • 216 citations

Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations

1997 • 204 citations

Molecular characterization of human and bovine endothelin converting enzyme (ECE‐1)

1994 • 200 citations

Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development

2000 • 190 citations

Endothelins: Homeostatic and Compensatory Actions in the Circulatory and Endocrine Systems

1993 • 182 citations

A fourth isoform of endothelin‐converting enzyme (ECE‐1) is generated from an additional promoter

1999 • 169 citations

Regulation of the endothelin system by shear stress in human endothelial cells

2000 • 160 citations

Secretion, Surface Localization, Turnover, and Steady State Expression of Protein Disulfide Isomerase in Rat Hepatocytes

1995 • 154 citations

Conversion of big endothelin-1 by membrane-bound matalloendopeptidase in cultured bovine endothelial cells

1990 • 132 citations

Cell Surface Protein Disulfide-Isomerase Is Involved in the Shedding of Human Thyrotropin Receptor Ectodomain

1996 • 128 citations

Physical Proximity and Functional Association of Glycoprotein 1bα and Protein-disulfide Isomerase on the Platelet Plasma Membrane

2000 • 127 citations

Localization of rat endothelin-converting enzyme to vascular endothelial cells and some secretory cells

1995 • 114 citations

Processing of proendothelin‐1 by human furin convertase

1995 • 102 citations

Human Endothelial Cell Storage Granules

1998 • 99 citations

Identification of endothelin 1 and big endothelin 1 in secretory vesicles isolated from bovine aortic endothelial cells.

1995 • 96 citations

Rat endothelin-converting enzyme-1 forms a dimer through Cys412 with a similar catalytic mechanism and a distinct substrate binding mechanism compared with neutral endopeptidase-24.11

1996 • 94 citations

Regulation of Endothelin-1 Synthesis by Endothelin-converting Enzyme-1 during Wound Healing

1999 • 90 citations

Distinct Reading of Different Structural Determinants Modulates the Dileucine-mediated Transport Steps of the Lysosomal Membrane Protein LIMPII and the Insulin-sensitive Glucose Transporter GLUT4

2000 • 87 citations

Cellular Distribution of Endothelin-converting Enzyme-1 in Human Tissues

1999 • 84 citations

Biosynthesis, Distinct Post-translational Modifications, and Functional Characterization of Lymphoma Proprotein Convertase

1997 • 81 citations

Modulation of Human Colon Tumor-Stromal Interactions by the Endothelin System

2000 • 76 citations

Isoforms of endothelin-converting enzyme: why and where?

1998 • 67 citations

Development of an Internally Quenched Fluorescent Substrate Selective for Endothelin-Converting Enzyme-1

2000 • 61 citations

The endothelin system and endothelin-converting enzyme in the brain: molecular and cellular studies.

1997 • 56 citations

Evidence of alternative promoters directing isoform-specific expression of human endothelin-converting enzyme-1 mRNA in cultured endothelial cells

1997 • 55 citations

Constitutive Lysosomal Targeting and Degradation of Bovine Endothelin-converting Enzyme-1a Mediated by Novel Signals in Its Alternatively Spliced Cytoplasmic Tail

1999 • 50 citations

Processing of proendothelin‐1 by members of the subtilisin‐like pro‐protein convertase family

2002 • 48 citations

Distinct Cellular Localization and Regulation of Endothelin-1 and Endothelin-Converting Enzyme-1 Expression in the Bovine Corpus Luteum: Implications for Luteolysis

2001 • 46 citations

Recombinant human endothelin-converting enzyme ECE-1b is located in an intracellular compartment when expressed in polarized Madin–Darby canine kidney cells

1998 • 43 citations

Metallopeptidase inhibitors induce an up-regulation of endothelin-converting enzyme levels and its redistribution from the plasma membrane to an intracellular compartment

1996 • 43 citations

Construction, expression and characterization of a soluble form of human endothelin‐converting‐enzyme‐1

1997 • 37 citations

Cyclic Expression of Endothelin-converting Enzyme-1 Mediates the Functional Regulation of Seminiferous Tubule Contraction

1999 • 33 citations

Two di-leucine-based motifs account for the different subcellular localizations of the human endothelin-converting enzyme (ECE-1) isoforms

1999 • 33 citations

A Live-Cell Assay for Studying Extracellular and Intracellular Endothelin-Converting Enzyme Activity

1997 • 32 citations

Use of pre‐embedding ultrastructural immunocytochemistry in the localization of a secretory product and membrane proteins in cultured prolactin cells

1986 • 30 citations

Processing of Proendothelin‐1 at the C‐Terminus of Big Endothelin‐1 is Essential for Proteolysis by Endothelin‐Converting Enzyme‐1 in vivo

1997 • 29 citations

Endothelin Is an Autocrine Regulator of Prolactin Secretion**This work was supported by NIH Grants HD-11669 and DK-43200 (to M.E.F.).

1998 • 28 citations

Transcriptional Mechanism of Protein Kinase C-Induced Isoform-Specific Expression of the Gene for Endothelin-Converting Enzyme-1in Human Endothelial Cells

2001 • 27 citations

Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization

2001 • 26 citations

Molecular isolation and characterization of novel four subisoforms of ECE-2

2002 • 26 citations

Single-Cell Characterization of Endothelin System Gene Expression in the Cerebellum In Situ

1998 • 21 citations

Effect of an Antisense Oligodeoxynucleotide to Endothelin-Converting Enzyme-1c (ECE-1c) on ECE-1c mRNA, ECE-1 Protein and Endothelin-1 Synthesis in Bovine Pulmonary Artery Smooth Muscle Cells

2001 • 18 citations

The N-terminal segment of endothelin-converting enzyme (ECE)-1b contains a di-leucine motif that can redirect neprilysin to an intracellular compartment in Madin–Darby canine kidney (MDCK) cells

1999 • 17 citations

Palmitoylation of the three isoforms of human endothelin-converting enzyme-1

1999 • 17 citations

Distribution of Endothelin 3-Like Immunoreactivity in Gonadotrophs of the Bullfrog (Rana catesbeiana) Pituitary

1997 • 16 citations

Expression of the Endothelin-Converting Enzyme-1 Isoforms in Endothelial Cells

2000 • 14 citations

Localization of the Endothelin System in Aldosterone-Producing Adenomas

2001 • 13 citations

Long-Term Regulation of Catecholamine Formation by Ouabain in Cultured Bovine Adrenal Chromaffin Cells

2000 • 7 citations

Differential Inhibition of Wild-Type Endothelin-Converting Enzyme-1 and Its Mutants

1998 • 3 citations