Endothelin-1 Protects Ovarian Carcinoma Cells against Paclitaxel-Induced Apoptosis: Requirement for Akt Activation

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

Paclitaxel (Taxol)

1995 • 1,747 citations

Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.

1994 • 1,631 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

Molecular regulation of apoptosis: Genetic controls on cell death

1993 • 923 citations

Inactivation of Bcl-2 by phosphorylation.

1995 • 744 citations

Endothelins

1995 • 682 citations

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1996 • 654 citations

Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.

1996 • 376 citations

Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis.

2000 • 216 citations

Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: evidence for an autocrine role in tumor growth.

1999 • 205 citations

Endothelin-1 is an autocrine/paracrine growth factor for human cancer cell lines.

1991 • 198 citations

Role of Endothelin-1 in Neovascularization of Ovarian Carcinoma

2000 • 188 citations

Endothelin-1 as an Autocrine/Paracrine Apoptosis Survival Factor for Endothelial Cells

1997 • 183 citations

Endothelin-1 induces tumor proteinase activation and invasiveness of ovarian carcinoma cells.

2001 • 160 citations

The control of apoptosis in mammalian cells

1993 • 139 citations

The phosphatidylinositol 3-kinase/AKT signal transduction pathway plays a critical role in the expression of p21WAF1/CIP1/SDI1 induced by cisplatin and paclitaxel.

2000 • 137 citations

Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells.

2000 • 127 citations

Activation of mitogenic signaling by endothelin 1 in ovarian carcinoma cells.

1997 • 120 citations

Natriuretic Peptides and Nitric Oxide Induce Endothelial Apoptosis via a cGMP–Dependent Mechanism

1999 • 112 citations

Regulation of the p53 protein by the MDM2 oncoprotein--thirty-eighth G.H.A. Clowes Memorial Award Lecture.

1999 • 111 citations

Endothelin attenuates apoptosis in human smooth muscle cells

1997 • 111 citations

Autocrine actions of endothelin-1 as a growth factor in human ovarian carcinoma cells.

1995 • 105 citations

Increase of cisplatin sensitivity by c-myc antisense oligodeoxynucleotides in a human metastatic melanoma inherently resistant to cisplatin.

1999 • 102 citations

Endothelin-1 Inhibits Apoptosis of Vascular Smooth Muscle Cells Induced by Nitric Oxide and Serum Deprivation via MAP Kinase Pathway

2000 • 97 citations

Pharmacodynamics of immediate and delayed effects of paclitaxel: role of slow apoptosis and intracellular drug retention.

1998 • 91 citations

The Endothelin System in Human Glioblastoma

2000 • 87 citations

Neutral endopeptidase inhibits neuropeptide-mediated transactivation of the insulin-like growth factor receptor-Akt cell survival pathway.

2001 • 77 citations

Endothelins as Autocrine Regulators of Tumor Cell Growth

1998 • 76 citations

Endothelin-1 Is a Potent Survival Factor for c-Myc-Dependent Apoptosis

1998 • 73 citations

Endothelin receptor blockade potentiates FasL-induced apoptosis in rat colon carcinoma cells

2000 • 62 citations

Lonidamine induces apoptosis in drug-resistant cells independently of the p53 gene.

1996 • 60 citations

Endothelin-1 Attenuates ω3 Fatty Acid–Induced Apoptosis by Inhibition of Caspase 3

2000 • 48 citations

The insulin-like growth factor 1 receptor induces transformation and tumorigenicity of ovarian mesothelial cells and down-regulates their Fas-receptor expression.

1999 • 47 citations

Endothelin Receptor Blockade Potentiates FasL-Induced Apoptosis in Colon Carcinoma Cells Via The Protein Kinase C-Pathway

2000 • 37 citations

Endothelin-1 Is a Potent Survival Factor for c-Myc-Dependent Apoptosis

1998 • 16 citations

Induction of apoptosis and inhibition of cellular proliferation as a dual approach to treatment of ovarian cancer.

1999 • 6 citations

Deleted Work

1955 • 0 citations