Idazoxan down-regulates β-adrenoceptors on C6 glioma cells in vitro

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Receptor-effector coupling by G proteins

1990 • 1,117 citations

Development of β-adrenergic receptor subsensitivity by antidepressants

1977 • 727 citations

Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain

1975 • 599 citations

A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data.

1980 • 545 citations

[41] LIGAND: A computerized analysis of ligand binding data

1983 • 324 citations

beta-Adrenergic receptor agonists increase phospholipid methylation, membrane fluidity, and beta-adrenergic receptor-adenylate cyclase coupling.

1979 • 308 citations

The effect of psychoactive drugs on beta-adrenergic receptor binding sites in rat brain

1980 • 188 citations

[3H]idazoxan and some other alpha 2-adrenergic drugs also bind with high affinity to a nonadrenergic site.

1989 • 174 citations

Chronic antidepressant therapy and associated changes in central monoaminergic receptor functioning

1983 • 160 citations

Neuro-Psychopharmacology

1978 • 133 citations

A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs.

1990 • 130 citations

Acceleration of β-receptor desensitization in combined administration of antidepressants and phenoxybenzamine

1981 • 118 citations

Phorbol esters and beta-adrenergic agonists mediate desensitization of adenylate cyclase in rat glioma C6 cells by distinct mechanisms.

1985 • 116 citations

Agonist-Promoted High Affinity State of the β-Adrenergic Receptor in Human Neutrophils: Modulation by Corticosteroids*

1981 • 99 citations

Quantitative autoradiography of central beta adrenoceptor subtypes: comparison of the effects of chronic treatment with desipramine or centrally administered l-isoproterenol.

1988 • 95 citations

Regulation of recognition and action function of the norepinephrine (NE) receptor-coupled adenylate cyclase system in brain: Implications for the therapy of depression

1983 • 79 citations

Desensitization of β‐Adrenergic Receptor‐Coupled Adenylate Cyclase in Cerebral Cortex After In Vivo Treatment of Rats with Desipramine

1986 • 62 citations

G proteins and cardiovascular disease.

1988 • 57 citations

Comparison of two putatively selective radioligands for labeling central nervous system beta-adrenergic receptors: inadequacy of [3H]dihydroalprenolol.

1989 • 56 citations

Reevaluation of the regulation of beta-adrenergic receptor binding by desipramine treatment.

1989 • 55 citations

Effect of the Tricyclic Antidepressant Desipramine on β‐Adrenergic Receptors in Cultured Rat Glioma C6 Cells

1987 • 54 citations

Down-regulation of β-adrenergic activity in astroglia by chronic treatment with an antidepressant drug

1981 • 49 citations

Chronic exposure of human cells in culture to the tricyclic antidepressant desipramine reduces the number of beta-adrenoceptors

1986 • 49 citations

Organspecific, qualitative changes in the phospholipid composition of rats after chronic administration of the antidepressant drug desipramine

1988 • 34 citations

Desensitization by Antidepressants of Central Norepinephrine Receptor Systems Coupled to Adenylate Cyclase^a

1984 • 33 citations

Rapid desensitization of cerebral cortical β-adrenergic receptors induced by desmethylimipramine and phenoxybenzamine

1980 • 31 citations

Pharmacokinetics of Maprotiline and Its Demethylated Metabolite in Serum and Specific Brain Regions of Rats after Acute and Chronic Administration of Maprotiline

1991 • 30 citations

The relationship of therapeutic response to antidepressant plasma levels: an update.

1982 • 28 citations

Pharmacokinetics of Amitriptyline and its Demethylated Metabolite in Serum and Specific Brain Regions of Rats After Acute and Chronic Administration of Amitriptyline

1990 • 27 citations

Single and multiple desipramine exposures of cultured cells

1990 • 27 citations

Direct influence of antidepressants on GTP binding protein of adenylate cyclase in cell membranes of the cerebral cortex of rats

1988 • 21 citations

Neuroanatomically selective down-regulation of beta adrenergic receptors by chronic imipramine treatment: relationships to the topography of [3H]imipramine and [3H] desipramine binding sites.

1989 • 21 citations

Modulation of peripheral beta-1 and alpha-2 receptor sensitivities by the administration of the tricyclic antidepressant, imipramine, alone and in combination with alpha-2 antagonists to rats.

1986 • 19 citations

Reduction in β‐Adrenoceptor Density in Cultured Rat Glioma C6 Cells After Incubation with Antidepressants Is Dependent upon the Culturing Conditions Used

1990 • 15 citations

Dual aminergic regulation of central beta adrenoceptors Effect of ?atypical? antidepressants and 5-hydroxytryptophan

1989 • 14 citations

Chronic exposure of C6 glioma cells to desipramine desensitizes ß-adrenoceptors, but increases ratio

1991 • 13 citations

Electroconvulsive shock decreases β-adrenoceptors despite serotonin lesions

1988 • 10 citations

Effects of desipramine administration on receptor-adenylate cyclase coupling in rat cerebral cortex

1988 • 10 citations

Ten day administration of desipramine produces an increase in KL/KH for β-receptors in rat hippocampus

1989 • 9 citations

Effects of some antidepressant drugs on the activity of glial cell enzymes in culture

1989 • 8 citations

Effect of Antidepressants on the GTP Binding: Sites in Rat Brain Homogenate

1990 • 7 citations

Involvement of protein kinase in the regulation of beta-adrenergic receptors by antidepressants.

1989 • 4 citations