Tubulin, Gq, and Phosphatidylinositol 4,5-Bisphosphate Interact to Regulate Phospholipase Cβ1 Signaling

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Microtubule Assembly in the Absence of Added Nucleotides

1973 • 2,055 citations

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

[31] Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands

1988 • 1,048 citations

Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G _q

1991 • 886 citations

G proteins

1992 • 871 citations

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

1991 • 774 citations

Regulation of inositol phospholipid-specific phospholipase C isozymes.

1992 • 740 citations

Regulation of Phospholipase C-γ1 by Profilin and Tyrosine Phosphorylation

1991 • 532 citations

The Actin-Binding Protein Profilin Binds to PIP ₂ and Inhibits Its Hydrolysis by Phospholipase C

1990 • 472 citations

Ras -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites

1986 • 450 citations

Activation of phospholipase C isozymes by G protein beta gamma subunits.

1993 • 306 citations

Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.

1991 • 288 citations

Reconstitutively active G protein-coupled receptors purified from baculovirus-infected insect cells.

1991 • 283 citations

Tubulin binds specifically to the signal-transducing proteins, Gs alpha and Gi alpha 1.

1990 • 204 citations

Beta gamma-subunit activation of G-protein-regulated phospholipase C.

1992 • 197 citations

Purification and characterization of two G-proteins that activate the beta 1 isozyme of phosphoinositide-specific phospholipase C. Identification as members of the Gq class.

1991 • 191 citations

Activation of cytosolic phosphoinositide phospholipase C by G-protein beta gamma subunits

1992 • 188 citations

The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2

1993 • 178 citations

Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.

1992 • 176 citations

Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq

1993 • 161 citations

Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells.

1992 • 161 citations

Purification of an AlF4- and G-protein beta gamma-subunit-regulated phospholipase C-activating protein

1991 • 135 citations

Enhancement of β-adrenergic responses by Gi-linked receptors in rat hippocampus

1993 • 122 citations

Effect of Monolayer Surface Pressure on the Activities of Phosphoinositide-Specific Phospholipase C-.beta.1, -.gamma.1, and -.delta.1

1994 • 119 citations

Tubulin-G Protein Association Stabilizes GTP Binding and Activates GTPase: Cytoskeletal Participation in Neuronal Signal Transduction

1994 • 114 citations

Tubulin-G protein interactions involve microtubule polymerization domains

1991 • 102 citations

G protein binding and G protein activation by nucleotide transfer involve distinct domains on tubulin: Regulation of signal transduction by cytoskeletal elements

1993 • 97 citations

Enhanced phospholipase C stimulation and transformation in NIH-3T3 cells expressing Q209LGq-alpha-subunits.

1992 • 86 citations

Expression and purification of functional G protein alpha subunits using a baculovirus expression system.

1992 • 85 citations

Chimeric G alpha s/G alpha i2 proteins define domains on G alpha s that interact with tubulin for beta-adrenergic activation of adenylyl cyclase.

1994 • 80 citations

Melatonin Receptor‐Mediated Stimulation of Phosphoinositide Breakdown in Chick Brain Slices

1995 • 79 citations

Exchange of Guanine Nucleotides Between Tubulin and GTP‐Binding Proteins That Regulate Adenylate Cyclase: Cytoskeletal Modification of Neuronal Signal Transduction

1988 • 76 citations

Mutant but not normal p21 ras elevates inositol phospholipid breakdown in two different cell systems.

1988 • 53 citations

Structure of molecular aggregates of 1-(3-sn-phosphatidyl)-l-myo-inositol 3,4-bis(phosphate) in water

1981 • 46 citations

Association of a receptor and G-protein-regulated phospholipase C with the cytoskeleton

1992 • 45 citations

[3H]Pirenzepine and [3H]quinuclidinyl benzilate binding to brain muscarinic cholinergic receptors. Differences in measured receptor density are not explained by differences in receptor isomerization.

1984 • 43 citations

Synaptic Membrane G Proteins Are Complexed with Tubulin In Situ

1996 • 40 citations

[8] Photoaffinity guanosine 5′-triphosphate analogs as a tool for the study of GTP-binding proteins

1994 • 23 citations

Several Metabolic Factors Governing the Dynamics of Microtubule Assembly and Disassembly

1986 • 5 citations

Adenylyl cyclase, G proteins, and synaptic plasticity

1995 • 1 citations