Alterations in Detergent Solubility of Heterotrimeric G Proteins after Chronic Activation of G_i/o-Coupled Receptors: Changes in Detergent Solubility Are in Correlation with Onset of Adenylyl Cyclase Superactivation

G PROTEIN–COUPLED RECEPTOR KINASES

1998 • 1,335 citations

GPI-anchored proteins are organized in submicron domains at the cell surface

1998 • 1,207 citations

THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION

1998 • 1,074 citations

G PROTEIN βγ SUBUNITS

1997 • 834 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

Modulation of Ca2+ channels βγ G-protein py subunits

1996 • 805 citations

Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.

1975 • 663 citations

Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits

1992 • 623 citations

Evidence for a Regulated Interaction between Heterotrimeric G Proteins and Caveolin

1995 • 612 citations

Drug addiction: A model for the molecular basis of neural plasticity

1993 • 548 citations

Purification of the regulatory component of adenylate cyclase.

1980 • 497 citations

Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

1987 • 356 citations

Bradykinin Sequesters B2 Bradykinin Receptors and the Receptor-coupled Gα Subunits Gαq and Gαiin Caveolae in DDT1 MF-2 Smooth Muscle Cells

1997 • 256 citations

Organization of G Proteins and Adenylyl Cyclase at the Plasma Membrane

1997 • 211 citations

G-protein beta gamma dimers. Membrane targeting requires subunit coexpression and intact gamma C-A-A-X domain.

1991 • 203 citations

Chronic Opioid Treatment Induces Adenylyl Cyclase V Superactivation

1996 • 198 citations

Immunoisolation and partial characterization of endothelial plasmalemmal vesicles (caveolae).

1997 • 195 citations

Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein.

1993 • 186 citations

Receptor and effector interactions of G_s Functional studies with antibodies to the α_s carboxyl‐terminal decapeptide

1989 • 176 citations

Regulation of G Protein-coupled Receptor Kinases by Caveolin

1999 • 173 citations

Opiate-induced Adenylyl Cyclase Superactivation Is Isozyme-specific

1997 • 172 citations

Adenylylcyclase Supersensitization in μ-Opioid Receptor-transfected Chinese Hamster Ovary Cells Following Chronic Opioid Treatment

1995 • 162 citations

Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration.

1991 • 136 citations

G protein activation by human dopamine D3 receptors in high-expressing Chinese hamster ovary cells: A guanosine-5'-O-(3-[35S]thio)- triphosphate binding and antibody study.

1999 • 90 citations

Inhibition of adenylyl cyclase isoforms V and VI by various G_βγsubunits

1998 • 89 citations

G Protein β1γ2 Subunits Promote Microtubule Assembly

1997 • 86 citations

Differential Modulation of Adenylyl Cyclases I and II by Various Gβ Subunits

1998 • 80 citations

Guilty by insolubility - does a protein's detergent insolubility reflect a caveolar location?

1995 • 78 citations

Isoform-specific sensitization of adenylyl cyclase activity by prior activation of inhibitory receptors: role of beta gamma subunits in transducing enhanced activity of the type VI isoform.

1996 • 78 citations

Chronic antidepressant treatment facilitates G protein activation of adenylyl cyclase without altering G protein content.

1995 • 78 citations

Regulation of Adenylyl Cyclase Isozymes on Acute and Chronic Activation of Inhibitory Receptors

1998 • 72 citations

Molecular mechanisms of agonist-induced desensitization of the cloned mouse kappa opioid receptor.

1994 • 70 citations

The subcellular localization of the G-protein Gi alpha in the basal ganglia reveals its potential role in both signal transduction and vesicle trafficking

1992 • 50 citations

Long‐Term Opiate Exposure Leads to Reduction of the αi‐1 Sufyunit of GTP‐Binding Proteins

1989 • 49 citations

Enhanced Stimulatory Adenylyl Cyclase Signaling during Opioid Dependence Is Associated with a Reduction in Palmitoylated G_sα

1997 • 46 citations

κ‐Opioid receptor‐transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opioid treatments

1995 • 44 citations

μ-Opioid receptor-regulated adenylate cyclase activity in primary cultures of rat striatal neurons upon chronic morphine exposure

1991 • 39 citations

Induction of Multiple Effects on Adenylyl Cyclase Regulation by Chronic Activation of the Human A₃Adenosine Receptor

1997 • 32 citations

Inhibition of adenylyl cyclase isoforms V and VI by various Gbg subunits

1998 • 17 citations

Transforming growth factors β1 and β2 as well as milk growth factor decrease anti‐CD3‐induced proliferation of human lymphocytes without inhibiting the anti‐CD3‐mediated increase of [Ca²⁺]_i and the activation of protein kinase C

1989 • 13 citations