Cross-talk between Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) and Peroxisome Proliferator-activated Receptor-α (PPARα) Signaling Pathways

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

STATs and Gene Regulation

1997 • 3,927 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

1997 • 2,100 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

1995 • 1,626 citations

The PPARα–leukotriene B4 pathway to inflammation control

1996 • 1,328 citations

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

1992 • 1,200 citations

Fatty Acids, Eicosanoids, and Hypolipidemic Agents Identified as Ligands of Peroxisome Proliferator-Activated Receptors by Coactivator-Dependent Receptor Ligand Assay

1997 • 1,158 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ

1996 • 1,033 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

1988 • 897 citations

Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids

1995 • 700 citations

Functional interactions between Stat5 and the glucocorticoid receptor

1996 • 681 citations

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

1995 • 641 citations

Rational Design of Potent Antagonists to the Human Growth Hormone Receptor

1992 • 633 citations

Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes

1995 • 578 citations

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

1995 • 556 citations

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.

1993 • 516 citations

Peroxisome proliterator-activated receptors, orphans with ligands and functions

1997 • 494 citations

Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643

1997 • 487 citations

Differential activation of adipogenesis by multiple PPAR isoforms.

1996 • 470 citations

Regulation of Peroxisome Proliferator-activated Receptor γ Activity by Mitogen-activated Protein Kinase

1997 • 446 citations

Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300

1997 • 428 citations

Induction of the Acyl-Coenzyme A Synthetase Gene by Fibrates and Fatty Acids Is Mediated by a Peroxisome Proliferator Response Element in the C Promoter

1995 • 396 citations

Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity.

1995 • 374 citations

Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver.

1993 • 371 citations

Isolation and Characterization of PBP, a Protein That Interacts with Peroxisome Proliferator-activated Receptor

1997 • 340 citations

Prolactin and Growth Hormone in the Regulation of the Immune System

1991 • 321 citations

Expression of the Peroxisome Proliferator-activated Receptor α Gene Is Stimulated by Stress and Follows a Diurnal Rhythm

1996 • 317 citations

The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid.

1992 • 312 citations

Molecular Mechanism of Growth Hormone Action

1996 • 309 citations

Peroxisome proliferator activated receptors: transcriptional regulators of adipogenesis, lipid metabolism and more…

1995 • 293 citations

Novel Sequence Determinants in Peroxisome Proliferator Signaling

1995 • 285 citations

Deletion of the Carboxyl-Terminal Transactivation Domain of MGF-Stat5 Results in Sustained DNA Binding and a Dominant Negative Phenotype

1996 • 276 citations

STAT3 Acts as a Co-activator of Glucocorticoid Receptor Signaling

1997 • 236 citations

Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids.

1994 • 227 citations

Growth Hormone Activation of Stat 1, Stat 3, and Stat 5 in Rat Liver

1996 • 225 citations

A Regulatory Role for RIP140 in Nuclear Receptor Activation

1998 • 222 citations

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.

1994 • 211 citations

Cloning of Human Stat5B

1996 • 210 citations

Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone.

1992 • 207 citations

Activation of Acute Phase Response Factor (APRF)/Stat3 Transcription Factor by Growth Hormone

1995 • 180 citations

The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin.

1996 • 179 citations

Cloning and identification of mouse steroid receptor coactivator-1 (mSRC-1), as a coactivator of peroxisome proliferator-activated receptor gamma.

1996 • 176 citations

p300 Functions as a Coactivator for the Peroxisome Proliferator-activated Receptor α

1997 • 174 citations

Characterization of Stat5a and Stat5b Homodimers and Heterodimers and Their Association with the Glucocortiocoid Receptor in Mammary Cells

1998 • 164 citations

Stimulation by growth hormone of MAP kinase activity in 3T3-F442A fibroblasts.

1992 • 164 citations

Peroxisome proliferator-activated receptors: finding the orphan a home

1994 • 157 citations

Dexamethasone and Insulin Demonstrate Marked and Opposite Regulation of the Steady‐State mRNA Level of the Peroxisomal Proliferator‐Activated Receptor (PPAR) in Hepatic Cells

1994 • 143 citations

Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate.

1996 • 139 citations

Regulation of Signal Transducer and Activator of Transcription (STAT) 5b Activation by the Temporal Pattern of Growth Hormone Stimulation

1997 • 129 citations

Rapid changes in nuclear protein tyrosine phosphorylation after growth hormone treatment in vivo. Identification of phosphorylated mitogen-activated protein kinase and STAT91.

1994 • 123 citations

Promoter-dependent Synergy between Glucocorticoid Receptor and Stat5 in the Activation of β-Casein Gene Transcription

1997 • 123 citations

Thyroid hormone (T3) inhibits ciprofibrate-induced transcription of genes encoding beta-oxidation enzymes: cross talk between peroxisome proliferator and T3 signaling pathways.

1995 • 93 citations

Transcriptional Inhibition by Stat5

1997 • 92 citations

Hepatocarcinogenesis of Peroxisome Proliferators^a

1996 • 92 citations

Peroxisome proliferator-activated receptor gamma and the control of adipogenesis

1997 • 91 citations

Immunoregulatory properties of growth hormone and prolactin

1996 • 85 citations

Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter.

1994 • 85 citations

Inhibition of Peroxisome Proliferator Signaling Pathways by Thyroid Hormone Receptor

1997 • 82 citations

Characterization of protein-DNA interactions within the peroxisome proliferator-responsive element of the rat hydratase-dehydrogenase gene

1993 • 78 citations

Growth Hormone-Induced Tyrosyl Phosphorylation and Deoxyribonucleic Acid Binding Activity of Stat5A and Stat5B*

1997 • 71 citations

Sex-related difference in the inductions by perfluoro-octanoic acid of peroxisomal β-oxidation, microsomal 1-acylglycerophosphocholine acyltransferase and cytosolic long-chain acyl-CoA hydrolase in rat liver

1989 • 66 citations

Protein Expression, Characterization, and Regulation ofCYP4F4andCYP4F5Cloned from Rat Brain

1997 • 64 citations

Introduction of exogenous growth hormone receptors augments growth hormone-responsive insulin biosynthesis in rat insulinoma cells.

1990 • 60 citations

The Role of Peroxisome Proliferator Activated Receptor α in Peroxisome Proliferation, Physiological Homeostasis, and Chemical Carcinogenesis

1997 • 59 citations

Activation of immediate‐early gene expression by peroxisome proliferators in vitro

1993 • 49 citations

Activity of the carbamyl phosphate synthetase I promoter in liver nuclear extracts is dependent on a cis-acting C/EBP recognition element.

1989 • 47 citations

The production of growth hormone and insulin-like growth factor-I by the same subpopulation of rat mononuclear leukocytes

1992 • 43 citations

Growth Hormone Stimulation of the Mitogen-Activated Protein Kinase Pathway Is Cell Type Specific*

1998 • 36 citations

Peroxisomal leukotriene degradation: Biochemical and clinical implications

1993 • 30 citations

Effects of testosterone, hypophysectomy and growth hormone treatment on clofibrate induction of peroxisomal β-oxidation in female rat liver

1994 • 26 citations

Suppressive effect of growth hormone on the expression of peroxisome proliferator-activated receptor in cultured rat hepatocytes.

1995 • 25 citations

Hormonal Modulation of Peroxisomal Enzyme Induction Caused by Peroxisome Proliferators: Suppression by Growth and Thyroid Hormones in Cultured Rat Hepatocytes

1994 • 23 citations

Suppression of clofibrate-induction of peroxisomal and microsomal fatty acid-oxidizing enzymes by growth hormone and thyroid hormone in primary cultures of rat hepatocytes

1995 • 12 citations

Hepatic microsomal metabolism of leukotriene B₄in rats: Biochemical characterization, effect of inducers, and age- and sex-dependent differences

1989 • 8 citations