Localization of a phenobarbital-responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

A simple phase-extraction assay for chloramphenicol acyltransferase activity

1988 • 1,006 citations

Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro

1985 • 805 citations

Human CCAAT-binding proteins have heterologous subunits

1988 • 712 citations

Phenobarbital induction of cytochrome P-450 gene expression

1992 • 530 citations

Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix

1988 • 470 citations

Use of a low-speed, iso-density percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations

1986 • 385 citations

Transcriptional regulation of rat liver epoxide hydratase, NADPH-Cytochrome P-450 oxidoreductase, and cytochrome P-450b genes by phenobarbital.

1983 • 222 citations

Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response

1990 • 171 citations

Influence of Extracellular Matrix Overlay on Phenobarbital-Mediated Induction of CYP2B1, 2B2, and 3A1 Genes in Primary Adult Rat Hepatocyte Culture

1993 • 140 citations

Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver.

1983 • 133 citations

Sequences within the 5′-flanking region of the S14 gene confer responsiveness to glucose in primary hepatocytes

1989 • 115 citations

A barbiturate-regulated protein binding to a common sequence in the cytochrome P450 genes of rodents and bacteria.

1991 • 112 citations

Phenobarbital induction and tissue-specific expression of the rat CYP2B2 gene in transgenic mice.

1993 • 86 citations

Expression and function of three cytochrome P-450 isozymes in rat extrahepatic tissues

1987 • 68 citations

Functional Analysis of Developmentally Regulated Chromatin-Hypersensitive Domains Carrying the α₁-Fetoprotein Gene Promoter and the Albumin/α₁-Fetoprotein Intergenic Enhancer

1993 • 67 citations

Induction of cytochrome P-450 and 5-aminolevulinate synthase activities in cultured rat hepatocytes.

1990 • 52 citations

cDNA Clones for Liver Cytochrome P-450s from Individual Aroclor-Treated Rats: Constitutive Expression of a New P-450 Gene Related to Phenobarbital-Inducible Forms

1986 • 47 citations

Transcriptional regulation of the chicken CYP2H1 gene. Localization of a phenobarbital-responsive enhancer domain.

1991 • 46 citations

The phenobarbital-induced transcriptional activation of cytochrome P-450 genes is blocked by the glucocorticoid-progesterone antagonist RU486.

1993 • 45 citations

Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer.

1993 • 35 citations

Identification and functional characterization of acis-acting positive DNA element regulating CYP 2B1/B2 gene transcription in rat liver

1992 • 35 citations

A Constitutive Member of the Rat Cytochrome P450IIB Subfamily: Full-Length Coding Sequence of the P450IIB3 cDNA

1988 • 34 citations

[32] Hepatocyte culture in study of P450 regulation

1991 • 34 citations

The rat α₁-fetoprotein gene: characterization of the 5′-flanking region and tandem organization with the albumin gene

1987 • 33 citations

Analysis of the promoter of the cytochrome P-450 2B2 gene in the rat.

1992 • 15 citations