Phenobarbital Induction of CYP2B1/2 in Primary Hepatocytes: Endocrine Regulation and Evidence for a Single Pathway for Multiple Inducers

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1970 • 253,849 citations

Molecular Cloning: A Laboratory Manual

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Molecular Cloning. A Laboratory Manual

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Chapter 4 Preparation of Isolated Rat Liver Cells

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The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene

1998 • 697 citations

Phenobarbital induction of cytochrome P-450 gene expression

1992 • 530 citations

Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships.

1983 • 307 citations

Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone.

1987 • 177 citations

Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response

1990 • 171 citations

Activation by Diverse Xenochemicals of the 51-Base Pair Phenobarbital-Responsive Enhancer Module in theCYP2B10Gene

1998 • 160 citations

Localization of a phenobarbital-responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene

1995 • 156 citations

Characterization of a Phenobarbital-responsive Enhancer Module in Mouse P450 Cyp2b10 Gene

1997 • 139 citations

Regulation of cytochrome P-450p by phenobarbital and phenobarbital-like inducers in adult rat hepatocytes in primary monolayer culture and in vivo

1986 • 130 citations

Characterization of Phenobarbital-inducible Mouse Cyp2b10 Gene Transcription in Primary Hepatocytes

1996 • 109 citations

Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane.

1990 • 108 citations

Phenobarbital Induction Mediated by a Distal CYP2B2 Sequence in Rat Liver Transiently Transfected in Situ

1996 • 101 citations

A Novel Adrenocorticotropin-Inducible Cytochrome P450 from Rat Adrenal Microsomes Catalyzes Polycylic Aromatic Hydrocarbon Metabolism*

1991 • 95 citations

A pleiotropic response to phenobarbital-type enzyme inducers in the F344/NCr rat

1992 • 94 citations

Phenobarbital-inducible Aldehyde Dehydrogenase in the Rat

1989 • 93 citations

cAMP-associated Inhibition of Phenobarbital-inducible Cytochrome P450 Gene Expression in Primary Rat Hepatocyte Cultures

1995 • 92 citations

Modulation of xenobiotic-inducible cytochrome P450 gene expression by dexamethasone in primary rat hepatocytes

1995 • 89 citations

The CYP2B2 Phenobarbital Response Unit Contains an Accessory Factor Element and a Putative Glucocorticoid Response Element Essential for Conferring Maximal Phenobarbital Responsiveness

1998 • 88 citations

Effects of monoterpenoids on in vivo DMBA-DNA adduct formation and on phase I hepatic metabolizing enzymes

1991 • 87 citations

Phenobarbital induction and tissue-specific expression of the rat CYP2B2 gene in transgenic mice.

1993 • 86 citations

Cloned cytochrome P-450 cDNA. Nucleotide sequence and homology to multiple phenobarbital-induced mRNA species.

1983 • 85 citations

COMPARATIVE PHARMACODYNAMICS OF CYP2B INDUCTION BY DDT, DDE, AND DDD IN MALE RAT LIVER AND CULTURED RAT HEPATOCYTES

1998 • 72 citations

An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures.

1997 • 69 citations

Expression and function of three cytochrome P-450 isozymes in rat extrahepatic tissues

1987 • 68 citations

Differentiated induction of cytochrome P450b/e and P450p mRNAs by dose of phenobarbital in primary cultures of adult rat hepatocytes.

1990 • 61 citations

Difference in the susceptibility of two phenobarbital-inducible forms, P450IIB1 and P450IIB2, to thyroid hormone- and growth hormone-induced suppression in rat liver: phenobarbital-inducible P450IIB2 suppression by thyroid hormone acting directly, but not through the pituitary system.

1991 • 58 citations

Phenobarbital induction of hepatic CYP2B1 and CYP2B2: pretranscriptional and post-transcriptional effects of gender, adult age, and phenobarbital dose.

1996 • 53 citations

Steroid hormone receptor status defines the MMTV promoter chromatin structure in vivo

1995 • 50 citations

The phenobarbital-induced transcriptional activation of cytochrome P-450 genes is blocked by the glucocorticoid-progesterone antagonist RU486.

1993 • 45 citations

The Induction of Five Rat Hepatic P450 Cytochromes by Phenobarbital and Similarly Acting Compounds Is Regulated by a Sexually Dimorphic, Dietary-Dependent Endocrine Factor That Is Highly Strain Specific

1994 • 41 citations

Phenobarbital Alters Protein Binding to the CYP2B1/2Phenobarbital-responsive Unit in Native Chromatin

1997 • 38 citations

Phase II enzyme expression in rat liver in response to the antiestrogen tamoxifen.

1996 • 37 citations

Regulation of Phenobarbital-Inducible Cytochrome-P450 2B1/2 mRNA by Lovastatin and Oxysterols in Primary Cultures of Adult Rat Hepatocytes

1993 • 34 citations

Hepatic expression of CCAAT/enhancer binding protein α: hormonal and metabolic regulation in rats

1997 • 31 citations

Phenobarbital Induction of CYP2B1, CYP2B2, and CYP3A1 in Rat Liver: Genetic Differences in a Common Regulatory Mechanism

1995 • 29 citations

Basal and vitamin D-responsive activity of the rat osteocalcin promoter in stably transfected osteosarcoma cells: requirement of upstream sequences for control by the proximal regulatory domain.

1996 • 26 citations

C/EBPalpha is a regulator of the UDP glucuronosyltransferase UGT2B1 gene.

1998 • 23 citations

Role of interleukin 6 and corticosteroids in the regulation of expression of glutathione S-transferases in primary cultures of rat hepatocytes

1996 • 19 citations

Endocrine Factors Modulate the Phenobarbital-Mediated Induction of Cytochromes P450 and Phase II Enzymes in a Similar Strain-Dependent Manner

1998 • 17 citations

Characterization of a Pretranscriptional Pathway for Induction by Phenobarbital of Cytochrome P450 3A23 in Primary Cultures of Adult Rat Hepatocytes

1997 • 15 citations

Negative Regulation by Dexamethasone of Fluvastatin-Inducible CYP2B Expression in Primary Cultures of Rat Hepatocytes: Role of CYP3A

1998 • 12 citations