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Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

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Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

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A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

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Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

1998 • 586 citations

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1995 • 472 citations

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1996 • 274 citations

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1996 • 206 citations

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Serological analysis of cell surface antigens of malignant human brain tumors

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Macrophage inflammatory protein 3α transgene attracts dendritic cells to established murine tumors and suppresses tumor growth

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Imiquimod, a Topical Immune Response Modifier, in the Treatment of Cutaneous Metastases of Malignant Melanoma

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The Role of Antigen in the Localization of Naive, Acutely Activated, and Memory CD8+ T Cells to the Lung During Influenza Pneumonia

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Analysis of mouse dendritic cell migration in vivo upon subcutaneous and intravenous injection

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Preferential Accumulation of Antigen-specific Effector CD4 T Cells at an Antigen Injection Site Involves CD62E-dependent Migration but Not Local Proliferation

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Detection and localization of MIP‐3α/LARC/exodus, a macrophage proinflammatory chemokine, and its CCR6 receptor in human pancreatic cancer

1999 • 143 citations

Intratumoral injection of dendritic cells derived in vitro in patients with metastatic cancer

2000 • 143 citations

Cutting Edge: Differential Effect of Apoptotic Versus Necrotic Tumor Cells on Macrophage Antitumor Activities

1999 • 142 citations

Upon dendritic cell (DC) activation chemokines and chemokine receptor expression are rapidly regulated for recruitment and maintenance of DC at the inflammatory site

1999 • 133 citations

Intratumoral Administration of Adenoviral Interleukin 7 Gene-Modified Dendritic Cells Augments Specific Antitumor Immunity and Achieves Tumor Eradication

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1998 • 131 citations

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1999 • 129 citations

The dynamics of the T-cell antitumor response: chemokine-secreting dendritic cells can prime tumor-reactive T cells extranodally.

2001 • 127 citations

Local administration of dendritic cells inhibits established breast tumor growth: implications for apoptosis-inducing agents.

2001 • 124 citations

Combined intratumoral injection of bone marrow-derived dendritic cells and systemic chemotherapy to treat pre-existing murine tumors.

2001 • 122 citations

Detection and localization of MIP-3?/LARC/exodus, a macrophage proinflammatory chemokine, and its CCR6 receptor in human pancreatic cancer

1999 • 122 citations

Secondary necrosis is a source of proteolytically modified forms of specific intracellular autoantigens: Implications for systemic autoimmunity

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Radiation therapy for malignant melanoma

2003 • 118 citations

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2000 • 116 citations

CD40 Ligand-Dependent Activation of Cytotoxic T Lymphocytes by Adeno-Associated Virus Vectors In Vivo: Role of Immature Dendritic Cells

2000 • 116 citations

A role of interferon-gamma (IFN-gamma) in tumor immunity: T cells with the capacity to reject tumor cells are generated but fail to migrate to tumor sites in IFN-gamma-deficient mice.

2001 • 116 citations

Infiltration of tumors by systemically transferred tumor-reactive T lymphocytes is required for antitumor efficacy.

1999 • 115 citations

The pattern of cytokine gene expression in freshly excised human metastatic melanoma suggests a state of reversible anergy of tumor‐infiltrating lymphocytes

1994 • 115 citations

CC Chemokine Ligand 3 (CCL3) Regulates CD8⁺-T-Cell Effector Function and Migration following Viral Infection

2003 • 110 citations

Viral fusogenic membrane glycoproteins kill solid tumor cells by nonapoptotic mechanisms that promote cross presentation of tumor antigens by dendritic cells.

2002 • 110 citations

Tumor Escape from Immune Response by Variation in HLA Expression and Other Mechanisms

1993 • 107 citations

Tumor-infiltrating dendritic cells in adenocarcinomas of the breast: a study of 143 neoplasms with a correlation to usual prognostic factors and to clinical outcome

1999 • 107 citations

Targeting Apoptotic Tumor Cells to FcγR Provides Efficient and Versatile Vaccination Against Tumors by Dendritic Cells

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Cutaneous Injection of Human Subjects with Macrophage Inflammatory Protein-1α Induces Significant Recruitment of Neutrophils and Monocytes

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Systemic chemotherapy for the treatment of metastatic melanoma.

2002 • 101 citations

Modulation of antigen processing and presentation by covalently linked complement C3b fragment

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Use of Viral Fusogenic Membrane Glycoproteins as Novel Therapeutic Transgenes in Gliomas

2001 • 96 citations

CCR2+ and CCR5+ CD8+ T cells increase during viral infection and migrate to sites of infection

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Recombinant Human Granulocyte Macrophage-Colony Stimulating Factor (rhGM-CSF) and Autologous Melanoma Vaccine Mediate Tumor Regression in Patients with Metastatic Melanoma

1999 • 92 citations

Macrophages orchestrate the immune response to tumor cell death.

2001 • 90 citations

Viral fusogenic membrane glycoprotein expression causes syncytia formation with bioenergetic cell death: implications for gene therapy.

2000 • 86 citations

Rapid Peptide Turnover and Inefficient Presentation of Exogenous Antigen Critically Limit the Activation of Self-Reactive CTL by Dendritic Cells

2001 • 83 citations

Induction of tumor-specific protective immunity by in situ Langerhans cell vaccine

2002 • 83 citations

Enhancing the efficacy of a weak allogeneic melanoma vaccine by viral fusogenic membrane glycoprotein-mediated tumor cell-tumor cell fusion.

2002 • 79 citations

Genetic Immunotherapy of Established Tumors with Adenovirus-Murine Granulocyte-Macrophage Colony-Stimulating Factor

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Vaccination of Melanoma Patients with an Allogeneic, Genetically Modified Interleukin 2-Producing Melanoma Cell Line

2000 • 76 citations

Suppression of tumor metastasis by blockade of transforming growth factor beta signaling in bone marrow cells through a retroviral-mediated gene therapy in mice.

2002 • 75 citations

Vaccination against human cancers (review).

2000 • 73 citations

Bioactivity of Autologous Irradiated Renal Cell Carcinoma Vaccines Generated by Ex Vivo Granulocyte-Macrophage Colony-Stimulating Factor Gene Transfer

1998 • 71 citations

Endogenous Granulocyte-Macrophage Colony-Stimulating Factor Overexpression In Vivo Results in the Long-Term Recruitment of a Distinct Dendritic Cell Population with Enhanced Immunostimulatory Function

2002 • 71 citations

Synergistic enhancement of antitumor immunity with adoptively transferred tumor-specific CD4+ and CD8+ T cells and intratumoral lymphotactin transgene expression.

2002 • 67 citations

Tumor Infiltration by Adoptively Transferred T Cells Is Independent of Immunologic Specificity but Requires Down-Regulation of L-Selectin Expression

1999 • 67 citations

Antigen expressed on tumor cells fails to elicit an immune response, even in the presence of increased numbers of tumor-specific cytotoxic T lymphocyte precursors.

1998 • 64 citations

Intratumoral Dendritic Cell Vaccination Elicits Potent Tumoricidal Immunity Against Malignant Glioma in Rats

2003 • 63 citations

Intratumoral injection of dendritic cells after treatment of anticancer drugs induces tumor‐specific antitumor effect in vivo

2002 • 63 citations

Evidence for selection against human lung cancers bearing p53 missense mutations which occur within the HLA A*0201 peptide consensus motif.

1994 • 62 citations

Expression of inflammatory chemokines combined with local tumor destruction enhances tumor regression and long-term immunity.

2003 • 60 citations

Phase II study of carmustine, dacarbazine, cisplatin, and tamoxifen in advanced melanoma: a Southwest Oncology Group study.

1998 • 58 citations

Local administration of IL‐12–transfected dendritic cells induces antitumor immune responses to colon adenocarcinoma in the liver in mice

2002 • 57 citations

Immunopotentiating Role of IFN-γ in Early and Late Stages of Type 1 CD8 Effector Cell-Mediated Tumor Rejection

2001 • 56 citations

Adoptive transfer of immature dendritic cells with autologous or allogeneic tumor cells generates systemic antitumor immunity.

1999 • 52 citations

Feeding dendritic cells with tumor antigens: self-service buffet or à la carte?

2000 • 50 citations

Transfection of Macrophage Inflammatory Protein 1α into B16 F10 Melanoma Cells Inhibits Growth of Pulmonary Metastases But Not Subcutaneous Tumors

2002 • 49 citations

Induction of Chemokine Secretion and Enhancement of Contact-Dependent Macrophage Cytotoxicity by Engineered Expression of Granulocyte-Macrophage Colony-Stimulating Factor in Human Colon Cancer Cells

2000 • 45 citations

Phase I and Pharmacologic Study of the Combination of Paclitaxel, Cisplatin, and Topotecan Administered Intravenously Every 21 Days as First-Line Therapy in Patients With Advanced Ovarian Cancer

1999 • 44 citations

Treatment of Human Melanoma with a Hapten‐Modified Autologous Vaccinea

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RADIATION THERAPY FOR MALIGNANT MELANOMA

1996 • 43 citations

Imiquimod: Potential risk of an immunostimulant

2004 • 40 citations

Granulocyte/macrophage-colony-stimulating factor released by adenovirally transduced CT26 cells leads to the local expression of macrophage inflammatory protein 1α and accumulation of dendritic cells at vaccination sites in vivo

1999 • 40 citations

Synergistic effect of adoptive T-cell therapy and intratumoral interferon γ-inducible protein-10 transgene expression in treatment of established tumors

2002 • 39 citations

Aggregation of Antigen-Specific T Cells at the Inoculation Site of Mature Dendritic Cells

2002 • 32 citations

Antitumor effect of intratumoral administration of dendritic cell combination with vincristine chemotherapy in a murine fibrosarcoma model.

2003 • 32 citations

Enhancement of monocyte transendothelial migration by granulocyte-macrophage colony-stimulating factor: requirement for chemoattractant and CD11a / CD18 mechanisms

1999 • 25 citations

Cytotoxic T lymphocyte response against non-immunoselected tumor antigens predicts the outcome of gene therapy with IL-12-transduced tumor cell vaccine

1999 • 23 citations

HSV Amplicon-Mediated Delivery of LIGHT Enhances the Antigen-Presenting Capacity of Chronic Lymphocytic Leukemia

2002 • 21 citations

The role of radiation therapy in the treatment of head and neck cutaneous melanoma

1993 • 18 citations

Systemic chemotherapy for the treatment of metastatic melanoma

2002 • 13 citations

The CC chemokine MIP-1alpha induces a selective monocyte infiltration following intradermal injection into nonhuman primates.

1999 • 12 citations

Systemic Production of Human Granulocyte Colony-Stimulating Factor in Nonhuman Primates by Transplantation of Genetically Modified Myoblasts

2000 • 11 citations