Synergistic enhancement of antitumor immunity with adoptively transferred tumor-specific CD4+ and CD8+ T cells and intratumoral lymphotactin transgene expression.

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.

1994 • 2,251 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

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A new class of membrane-bound chemokine with a CX3C motif

1997 • 1,964 citations

Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family

1991 • 1,864 citations

A New Approach to the Adoptive Immunotherapy of Cancer with Tumor-Infiltrating Lymphocytes

1986 • 1,787 citations

CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer.

1998 • 1,175 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

Specific T Helper Cell Requirement for Optimal Induction of Cytotoxic T Lymphocytes against Major Histocompatibility Complex Class II Negative Tumors

1998 • 611 citations

Chemokine and Chemokine Receptor Interactions Provide a Mechanism for Selective T Cell Recruitment to Specific Liver Compartments Within Hepatitis C-Infected Liver

1999 • 426 citations

The next frontier of molecular medicine: Delivery of therapeutics

1998 • 408 citations

Paracrine Cytokine Adjuvants in Cancer Immunotherapy

1995 • 373 citations

Tumor-Specific CD4+ T Cells Have a Major “Post-Licensing” Role in CTL Mediated Anti-Tumor Immunity

2000 • 337 citations

Tumor localization of adoptively transferred indium-111 labeled tumor infiltrating lymphocytes in patients with metastatic melanoma.

1989 • 332 citations

Chemokines, inflammation and the immune system.

1994 • 302 citations

Eliciting T Cell Immunity Against Poorly Immunogenic Tumors by Immunization with Dendritic Cell-Tumor Fusion Vaccines

1998 • 236 citations

Molecular cloning and functional characterization of human lymphotactin.

1995 • 223 citations

Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon gamma.

1993 • 221 citations

Localization of111Indium-labeled tumor infiltrating lymphocytes to tumor in patients receiving adoptive immunotherapy. Augmentation with cyclophosphamide and correlation with response

1994 • 201 citations

C‐C chemokines, but not the C‐X‐C chemokines interleukin‐8 and interferon‐γ inducible protein‐10, stimulate transendothelial chemotaxis of T lymphocytes

1995 • 197 citations

Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo.

1997 • 191 citations

Adoptive immunotherapy with vaccine-primed lymph node cells secondarily activated with anti-CD3 and interleukin-2.

1997 • 167 citations

Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants.

1994 • 167 citations

Intratumoral Coinjection of Two Adenoviruses, One Encoding the Chemokine IFN-γ-Inducible Protein-10 and Another Encoding IL-12, Results in Marked Antitumoral Synergy

2000 • 159 citations

Gene-Modified Tumor Vaccine with Therapeutic Potential Shifts Tumor-Specific T Cell Response from a Type 2 to a Type 1 Cytokine Profile

1998 • 154 citations

T cell-mediated, IFN-gamma-facilitated rejection of murine B16 melanomas.

1998 • 152 citations

Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations.

1995 • 129 citations

T-cell receptor transgenic analysis of tumor-specific CD8 and CD4 responses in the eradication of solid tumors.

1999 • 124 citations

Infiltration of tumors by systemically transferred tumor-reactive T lymphocytes is required for antitumor efficacy.

1999 • 115 citations

Purification of L-Selectinlow Cells Promotes the Generation of Highly Potent CD4 Antitumor Effector T Lymphocytes

1998 • 110 citations

Adenoviral Vectors Expressing Lymphotactin and Interleukin 2 or Lymphotactin and Interleukin 12 Synergize to Facilitate Tumor Regression in Murine Breast Cancer Models

1999 • 105 citations

Clinical observations on adoptive immunotherapy with vaccine-primed T-lymphocytes secondarily sensitized to tumor in vitro.

1993 • 88 citations

Th1 and Th2 Cell Clones to a Poorly Immunogenic Tumor Antigen Initiate CD8+ T Cell-Dependent Tumor Eradication In Vivo

2000 • 87 citations

Lymphotactin Expression by Engineered Myeloma Cells Drives Tumor Regression: Mediation by CD4+ and CD8+ T Cells and Neutrophils Expressing XCR1 Receptor

2001 • 73 citations

Regulation of adhesion molecule expression by CD8 T cells in vivo. II. Expression of L-selectin (CD62L) by memory cytolytic T cells responding to minor histocompatibility antigens.

1994 • 70 citations

Lymphotactin Acts as an Innate Mucosal Adjuvant

1999 • 69 citations

Treatment of Murine Gliomas by Adoptive Transfer ofex VivoActivated Tumor-Draining Lymph Node Cells

1997 • 68 citations

Neutrophils and B Cells Express XCR1 Receptor and Chemotactically Respond to Lymphotactin

2001 • 67 citations

Tumor Infiltration by Adoptively Transferred T Cells Is Independent of Immunologic Specificity but Requires Down-Regulation of L-Selectin Expression

1999 • 67 citations

The role of CD4+ tumor-infiltrating lymphocytes in human solid tumors

1995 • 57 citations

Treatment of Subcutaneous Tumor with Adoptively Transferred T Cells

1997 • 54 citations

Successful Adoptive Immunotherapy of MurinePoorly ImmunogenicTumor with Specific Effector Cells Generated from Gene-Modified Tumor-Primed Lymph Node Cells

1999 • 54 citations

A critical role for a peritumoral stromal reaction in the induction of T-cell migration responsible for interleukin-12-induced tumor regression.

1999 • 51 citations

Molecular cloning of mXCR1, the murine SCM‐1/lymphotactin receptor

1999 • 45 citations

Induction of Chemokine Secretion and Enhancement of Contact-Dependent Macrophage Cytotoxicity by Engineered Expression of Granulocyte-Macrophage Colony-Stimulating Factor in Human Colon Cancer Cells

2000 • 45 citations

The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4+ T cells

2000 • 34 citations

Regression of Engineered Tumor Cells Secreting Cytokines Is Related to a Shift in Host Cytokine Profile from Type 2 to Type 1

2000 • 31 citations

Combinational immunotherapy for established tumors with engineered tumor vaccines and adenovirus-mediated gene transfer

2000 • 23 citations

Rat mammary adenocarcinoma 13762 expressing IFN-gamma elicits antitumor CD4+ MHC class II-restricted T cells that are cytolytic in vitro and tumoricidal in vivo.

1995 • 23 citations

Cytotoxic CD4+ T cells associated with the expression of major histocompatibility complex class II antigen of mouse myeloma cells secreting interferon-gamma are cytolytic in vitro and tumoricidal in vivo.

1998 • 11 citations