Failure to induce organ-specific autoimmunity by breaking of tolerance: importance of the microenvironment

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

Disorders of motility and muscle tone with special reference to the corpus striatum

1925 • 1,408 citations

BIOCHEMISTRY OF ENDOTOXINS

1990 • 1,201 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Molecular mimicry and autoimmune disease

1987 • 943 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

T Cell Awareness of Paternal Alloantigens During Pregnancy

1995 • 568 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Autoimmune Diseases: The Failure of Self Tolerance

1990 • 495 citations

Hematopoietic stem cell compartment: Acute and late effects of radiation therapy and chemotherapy

1995 • 472 citations

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

1990 • 343 citations

Checkpoints in the progression of autoimmune disease: lessons from diabetes models.

1996 • 340 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

ASSOCIATION OF CYTOMEGALOVIRUS INFECTION WITH AUTOIMMUNE TYPE 1 DIABETES

1988 • 316 citations

Studies in listeriosis show the strong symbiosis between the innate cellular system and the T‐cell response

1997 • 270 citations

Autoimmune diabetes as a consequence of locally produced interleukin-2

1992 • 242 citations

Levels of Peripheral T Cell Tolerance Induced by Different Doses of Tolerogen

1994 • 229 citations

Adhesion receptors on bone marrow stromal cells: in vivo expression of vascular cell adhesion molecule-1 by reticular cells and sinusoidal endothelium in normal and gamma-irradiated mice

1996 • 208 citations

Autoimmune Hepatitis

1996 • 205 citations

The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen

1994 • 181 citations

Coexpression of B7-1 and viral (“self”) transgenes in pancreatic β cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes

1995 • 177 citations

Infection breaks T-cell tolerance

1992 • 174 citations

Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice.

1993 • 169 citations

Antigen presentation to cytotoxic T lymphocytes in vivo.

1995 • 168 citations

Peripheral deletion of autoreactive CD8⁺ T cells in transgenic mice expressing H‐2K^b in the liver

1995 • 138 citations

Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha.

1993 • 133 citations

PERSISTENT MEASLES VIRUS GENOME IN AUTOIMMUNE CHRONIC ACTIVE HEPATITIS

1987 • 130 citations

Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen

1992 • 128 citations

CTL access to tissue antigen is restricted in vivo.

1994 • 120 citations

Tolerance in Transgenic Mice Expressing Major Histocompatibility Molecules Extrathymically on Pancreatic Cells

1990 • 117 citations

Vascular adhesion molecule–1 and intercellular adhesion molecule–1 expression on rat liver cells after lipopolysaccharide administrationin vivo

1995 • 111 citations

Mechanisms underlying T-cell tolerance

1996 • 108 citations

Viruses, cytokines, antigens, and autoimmunity.

1996 • 102 citations

Peripheral Tolerance as a Multi‐Step Mechanism

1993 • 97 citations

Triggers of autoimmune disease in a murine TCR-transgenic model for multiple sclerosis.

1997 • 92 citations

Processing of exogenous heat-aggregated (denatured) and particulate (native) hepatitis B surface antigen for class I-restricted epitope presentation.

1995 • 91 citations

Inflammatory cytokines up-regulate intercellular adhesion molecule-1 expression on primary cultured mouse hepatocytes and T-lymphocyte adhesion

1994 • 90 citations

The Shaping of the Brain–Specific T Lymphocyte Repertoire in the Thymus

1996 • 66 citations

Alterations of bone marrow sinus endothelium induced by ionizing irradiation: implications in the homing of intravenously transplanted marrow cells.

1992 • 65 citations

T-cell tolerance and autoimmunity in transgenic models of central and peripheral tolerance

1994 • 64 citations

Listeria monocytogenes potently induces up-regulation of endothelial adhesion molecules and neutrophil adhesion to cultured human endothelial cells.

1997 • 58 citations

Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance

1995 • 54 citations

Breaking immunologic ignorance to an antigenic peptide of simian virus 40 large T antigen.

1995 • 44 citations

Listeria monocytogenes infection increases neutrophil adhesion and damage to a murine hepatocyte cell line in vitro

1995 • 38 citations

Organ injury associated with extrathymic induction of immune tolerance in doubly transgenic mice.

1992 • 38 citations

Infection and autoimmunity

1988 • 11 citations