Interferon induces insulin resistance in patients with chronic active hepatitis C

Glucose clamp technique: a method for quantifying insulin secretion and resistance.

1979 • 7,240 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM

1988 • 2,463 citations

Treatment of Chronic Hepatitis C with Recombinant Interferon Alfa

1989 • 1,658 citations

Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.

1985 • 1,147 citations

Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output.

1992 • 493 citations

Development of thyroid disease during therapy of chronic viral hepatitis with interferon alfa

1992 • 227 citations

Tumor necrosis factor-alpha- and hyperglycemia-induced insulin resistance. Evidence for different mechanisms and different effects on insulin signaling.

1996 • 222 citations

Ability of prolonged interferon treatment to suppress relapse after cessation of therapy in patients with chronic hepatitis C: A multicenter randomized controlled trial

1995 • 162 citations

Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output

1992 • 162 citations

Effect of Interferon on Glucose Tolerance and Insulin Sensitivity

1989 • 144 citations

Discrepancy between biochemical and virological responses to interferon-$alpha; in chronic hepatitis C

1993 • 133 citations

The Mechanism of the Carbohydrate Intolerance of Cirrhosis*

1980 • 126 citations

Influence of hyperglycemia on insulin's in vivo effects in type II diabetes.

1984 • 117 citations

Occurrence of IDDM during interferon therapy for chronic viral hepatitis

1994 • 66 citations

A noninvasive method to measure splanchnic glucose uptake after oral glucose administration.

1995 • 51 citations

Effect of interferon on glucose tolerance and insulin sensitivity

1989 • 44 citations

Serum ALT: Tarnished gold standard for interferon response in hepatitis C virus infection Johnson Y, Lau N, Mizokami M, Ohno T, Diamond DA, Kniffen J, Davis GL. Discrepancy between biochemical and virological responses to interferon-α in chronic hepatitis C. Lancet 1993; 342: 1208–1209

1994 • 33 citations

The Effect of Pioglitazone on Hepatic Glucose Uptake Measured With Indirect and Direct Methods in Alloxan-Induced Diabetic Dogs

1997 • 30 citations

Effect of strict metabolic control on glucose handling by the liver and peripheral tissues in non-insulin-dependent diabetes mellitus

1994 • 29 citations

Quantitative analysis of antibodies to hepatitis C virus during interferon-α therapy

1993 • 27 citations

The effect of pioglitazone on hepatic glucose uptake measured with indirect and direct methods in alloxan-induced diabetic dogs

1997 • 17 citations