The role of viruses in human diabetes

Virus-Induced Diabetes Mellitus

1979 • 1,011 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

EVIDENCE FOR A LONG PREDIABETIC PERIOD IN TYPE I (INSULIN-DEPENDENT) DIABETES MELLITUS

1981 • 480 citations

Virus-induced diabetes mellitus

1977 • 433 citations

A Prospective Study of the Role of Coxsackie B and Other Enterovirus Infections in the Pathogenesis of IDDM

1995 • 423 citations

Viral Antibodies in Diabetes Mellitus

1969 • 413 citations

Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes.

2000 • 375 citations

Seasonal Incidence of Diabetes Mellitus

1969 • 343 citations

Feasibility of genetic and immunological prediction of Type I diabetes in a population-based birth cohort

2001 • 336 citations

Enterovirus infection as a risk factor for beta-cell autoimmunity in a prospectively observed birth cohort: the Finnish Diabetes Prediction and Prevention Study.

2000 • 271 citations

Coxsackie B virus infection and onset of childhood diabetes

1995 • 268 citations

A new look at viruses in type 1 diabetes

2002 • 264 citations

The First Signs of β-Cell Autoimmunity Appear in Infancy in Genetically Susceptible Children from the General Population: The Finnish Type 1 Diabetes Prediction and Prevention Study

2001 • 215 citations

Maternal Enteroviral Infection During Pregnancy as a Risk Factor for ChildHood IDDM: A Population-Based Case-Control Study

1995 • 213 citations

Coxsackie Viruses and Diabetes Mellitus

1973 • 205 citations

Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase

2001 • 201 citations

Diabetes mellitus due to viruses ? some recent developments

1993 • 189 citations

Persistent Infection of Human Pancreatic Islets by Coxsackievirus B Is Associated with Alpha Interferon Synthesis in β Cells

2000 • 188 citations

Increased Level of Interferon‐α in Blood of Patients with Insulin‐Dependent Diabetes Mellitus: Relationship with Coxsackievirus B Infection

2000 • 179 citations

Islet Cell Antibody Seroconversion in Children Is Temporally Associated with Enterovirus Infections

1997 • 165 citations

Detection of Coxsackie B Virus RNA sequences in whole blood samples from adult patients at the onset of type I diabetes mellitus

1997 • 164 citations

Enterovirus RNA in serum is a risk factor for beta-cell autoimmunity and clinical type 1 diabetes: a prospective study. Childhood Diabetes in Finland (DiMe) Study Group.

2000 • 158 citations

Enterovirus RNA Is Found in Peripheral Blood Mononuclear Cells in a Majority of Type 1 Diabetic Children at Onset

2002 • 144 citations

Indications that maternal coxsackie B virus infection during pregnancy is a risk factor for childhood-onset IDDM

1995 • 139 citations

Several different enterovirus serotypes can be associated with prediabetic autoimmune episodes and onset of overt IDDM

1998 • 138 citations

Enterovirus variants in the serum of children at the onset of Type 1 diabetes mellitus

1999 • 119 citations

A TWENTY-FIVE-YEAR FOLLOW-UP OF CONGENITAL RUBELLA

1967 • 116 citations

A Case of Diabetes Mellitus Quickly Following Mumps

1899 • 108 citations

The Role of Enteroviral Infections in the Development of IDDM: Limitations of Current Approaches

1997 • 106 citations

Death of a Beta Cell: Homicide or Suicide?

1986 • 92 citations

Enterovirus antibody levels during the first two years of life in prediabetic autoantibody-positive children

2001 • 92 citations

Neonatal Type I diabetes associated with maternal echovirus 6 infection: a case report

2000 • 92 citations

The possible role of Coxsackie A and echo viruses in the pathogenesis of type I diabetes mellitus studied by IgM analysis

1992 • 84 citations

Rotavirus infections and development of diabetes-associated autoantibodies during the first 2 years of life

2002 • 78 citations

T-cell responses to enterovirus antigens in children with type 1 diabetes.

2000 • 77 citations

POLYMERASE CHAIN REACTION

1995 • 60 citations

Serological evaluation of the role of cytomegalovirus in the pathogenesis of IDDM: a prospective study

1995 • 58 citations

Proliferative lymphocyte responses to virus antigens homologous to GAD65 in IDDM

1996 • 57 citations

Juvenile diabetes as a sequel to mumps

1947 • 54 citations

A new look at viruses in type 1 diabetes

1995 • 50 citations

A Practical Approach to Identification of Susceptibility Genes for IDDM

1992 • 47 citations

Characterization of the T-Cell Response to Coxsackievirus B4

2002 • 45 citations

Coxsackievirus B3 infection in human leukocytes and lymphoid cell lines

1994 • 43 citations

Responses of Coxsackievirus B4-Specific T-Cell Lines to 2C Protein—Characterization of Epitopes with Special Reference to the GAD65 Homology Region

2001 • 40 citations

Onset of Type 1 diabetes mellitus in infancy after enterovirus infections

1998 • 39 citations

The IDDMK(1,2)22 retrovirus is not detectable in either mRNA or genomic DNA from patients with type 1 diabetes.

1999 • 36 citations

T cell Responses to Enterovirus Antigens and to β-cell Autoantigens in Unaffected Children Positive for IDDM-Associated Autoantibodies

1999 • 32 citations

The Antiviral 2′,5′-Oligoadenylate Synthetase Is Persistently Activated in Type 1 Diabetes

2000 • 32 citations

Insulin (Auto) Antibodies from Human IDDM Cross-react with Retroviral Antigen p73

1993 • 31 citations

Antibody reactivity to an Epstein–Barr virus BERF4-encoded epitope occurring also in Asp-57 region of HLA-DQ8 β chain

1994 • 31 citations

Simultaneous onset of Type 1 diabetes mellitus in identical infant twins with enterovirus infection

1998 • 30 citations

The role of enteroviral infections in the development of IDDM: limitations of current approaches

1997 • 29 citations

Decreased antibody reactivity to Epstein‐Barr virus capsid antigen in type 1 (insulin‐dependent) diabetes mellitus

1991 • 27 citations

A practical approach to identification of susceptibility genes for IDDM

1992 • 26 citations

Comparison of enterovirus-specific cellular immunity in two populations of young children vaccinated with inactivated or live poliovirus vaccines

1999 • 25 citations

Indications that maternal coxsackie B virus infection during pregnancy is a risk factor for childhood-onset IDDM

1995 • 24 citations

Complete nucleotide sequence of a beta‐cell tropic variant of coxsackievirus B4

1994 • 23 citations

The Production of Immunoreactive α‐and γ‐Interferon by Circulating Mononuclear Cells in Type 1 Diabetes

1991 • 10 citations

Serological evaluation of the role of cytomegalovirus in the pathogenesis of IDDM: a prospective study

1995 • 8 citations

Enterovirus RNA is found in a majority of IDDM children at onset

2000 • 2 citations