Autoimmune aspects of cytokine and anticytokine therapies

A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

1987 • 2,769 citations

Infliximab (chimeric anti-tumour necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial

1999 • 2,358 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

Treatment of Chronic Hepatitis C with Recombinant Interferon Alfa

1989 • 1,658 citations

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

1997 • 1,651 citations

Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial

2000 • 1,463 citations

Etanercept in Children with Polyarticular Juvenile Rheumatoid Arthritis

2000 • 1,211 citations

Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α

1993 • 1,031 citations

Demyelination occurring during anti-tumor necrosis factor ? therapy for inflammatory arthritides

2001 • 813 citations

A Controlled Trial of Interferon Gamma to Prevent Infection in Chronic Granulomatous Disease

1991 • 785 citations

Treatment of multiple sclerosis with gamma interferon

1987 • 739 citations

A Molecular Basis for MHC Class II—Associated Autoimmunity

1988 • 707 citations

Treatment of Ankylosing Spondylitis by Inhibition of Tumor Necrosis Factor α

2002 • 679 citations

T Helper Cell Subsets in Insulin-Dependent Diabetes

1995 • 600 citations

Tumour necrosis factor-α in murine autoimmune 'lupus' nephritis

1988 • 599 citations

The interferons. Mechanisms of action and clinical applications

1991 • 580 citations

TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination

1998 • 553 citations

Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor α: Findings in open-label and randomized placebo-controlled trials

2000 • 535 citations

Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells.

1993 • 507 citations

A survey of adverse events in 11 241 patients with chronic viral hepatitis treated with alfa interferon

1996 • 498 citations

Side effects of high-dose interferon therapy for chronic hepatitis C

1996 • 469 citations

Prolonged Survival in Chronic Myelogenous Leukemia after Cytogenetic Response to Interferon-α Therapy

1995 • 446 citations

Infliximab in the Treatment of Severe, Steroid-Refractory Ulcerative Colitis: A Pilot Study

2001 • 427 citations

In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon.

1987 • 396 citations

The Interferons

1991 • 380 citations

Etanercept therapy in children with treatment-resistant uveitis

2001 • 309 citations

Enhancement by Interferon of the Specific Cytotoxicity of Sensitized Lymphocytes

1972 • 308 citations

Exacerbation of symptoms of autoimmune disease in patients receiving alpha-interferon therapy

1990 • 301 citations

Interferon β decreases T cell activation and interferon γ production in multiple sclerosis

1993 • 264 citations

Current evidence for the induction of autoimmune rheumatic manifestations by cytokine therapy

2000 • 256 citations

Tumor necrosis factor and IL-1 in New Zealand Black/White mice. Enhanced gene expression and acceleration of renal injury.

1989 • 255 citations

Effectiveness of TNF-alpha blockade with infliximab in refractory Wegener's granulomatosis

2002 • 249 citations

Autoimmunity and thyroid function in patients with chronic active hepatitis treated with recombinant interferon alpha-2a

1995 • 237 citations

Alpha-2 interferon therapy of hairy-cell leukemia: a multicenter study of 64 patients.

1986 • 233 citations

Serum levels of interferons in patients with systemic lupus erythematosus.

1987 • 180 citations

Immunomodulatory Properties of Interferon‐γ: An Update^a

1998 • 179 citations

Immune-mediated and unusual complications during interferon alfa therapy in chronic myelogenous leukemia.

1995 • 175 citations

Chronic therapy with recombinant tumor necrosis factor-α in autoimmune NZB/NZW F1 mice

1989 • 169 citations

Lupus-like autoimmune disease induced by interferon therapy for myeloproliferative disorders

1992 • 165 citations

Cytolytic T cells with Th1-like cytokine profile predominate in retroorbital lymphocytic infiltrates of Graves' ophthalmopathy.

1993 • 160 citations

Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I.

1996 • 156 citations

Infliximab in patients with primary Sj�gren's syndrome: A pilot study

2001 • 153 citations

In Vivo Neutralization of TNF-α Promotes Humoral Autoimmunity by Preventing the Induction of CTL

2001 • 152 citations

Antinuclear Autoantibodies and Lupus Nephritis in Transgenic Mice Expressing Interferon γ in the Epidermis

1997 • 140 citations

Interleukin-2 in Scleroderma: Correlation of Serum Level with Extent of Skin Involvement and Disease Duration

1989 • 134 citations

Accelerated autoimmunity and lupus nephritis in NZB mice with an engineered heterozygous deficiency in tumor necrosis factor

2000 • 134 citations

Treatment of multiple myeloma with recombinant alpha-interferon

1986 • 129 citations

Development of systemic lupus erythematosus after interferon therapy for chronic myelogenous leukemia

1991 • 128 citations

Leukocytoclastic vasculitis due to etanercept.

2000 • 123 citations

Accelerated nodulosis and vasculitis following etanercept therapy for rheumatoid arthritis

2002 • 116 citations

Remission of Behcet's syndrome with tumour necrosis factor alpha blocking therapy

2001 • 115 citations

Interferon‐alpha up‐regulates bcl‐2 expression and protects B‐CLL cells from apoptosis in vitro and in vivo

1994 • 109 citations

Interferon-gamma and host antimicrobial defense: Current and future clinical applications

1994 • 109 citations

Antibodies against double-stranded DNA and development of polymyositis during treatment with interferon

1998 • 105 citations

High levels of bcl‐2 protein in circulating t lymphocytes, but not b lymphocytes, of patients with systemic lupus erythematosus

1994 • 103 citations

Multiple sclerosis and chronic inflammatory diseases A case-control study

2009 • 102 citations

Hypothyroidism during immunotherapy with interleukin-2 is associated with antithyroid antibodies and response to treatment.

1993 • 100 citations

Anticardiolipin antibodies in rheumatoid patients treated with etanercept or conventional combination therapy: direct and indirect evidence for a possible association with infections

2002 • 100 citations

Severe exacerbation of hepatitis C–associated vasculitic neuropathy following treatment with interferon alpha: A case report and literature review

2002 • 99 citations

Induction of systemic lupus erythematosus by interferon-gamma in a patient with rheumatoid arthritis.

1991 • 95 citations

Experimental autoimmune encephalomyelitis

1995 • 95 citations

Autoimmune Phenomena in Patients with Malignant Carcinoid Tumors During Interferon-α Treatment

1991 • 92 citations

Autoimmunity Resulting From Cytokine Treatment Predicts Long-Term Survival in Patients With Metastatic Renal Cell Cancer

1999 • 88 citations

Experimental Autoimmune Encephalomyelitis

2004 • 84 citations

Interferon-gamma induced exacerbation of systemic lupus erythematosus.

1990 • 78 citations

Soluble interleukin-2 receptor, interleukin-2 and interleukin-4 in sera and supernatants from patients with progressive systemic sclerosis

1990 • 76 citations

A randomized, double‐blind study comparing twenty‐four‐week treatment with recombinant interferon‐γ versus placebo in the treatment of rheumatoid arthritis

1997 • 75 citations

Alfa-2b interferon in the treatment of Hodgkin's disease and non-Hodgkin's lymphoma.

1987 • 71 citations

Interferon-α and interferon-γ reduce excessive collagen synthesis and procollagen mRNA levels of scleroderma fibroblasts in culture

1988 • 65 citations

Inhibition of interferon-gamma-induced major histocompatibility complex class II gene transcription by interferon-beta and type beta 1 transforming growth factor in human astrocytoma cells. Definition of cis-element.

1993 • 64 citations

Chronic inflammatory arthritis after treatment with high-dose interleukin-2 for malignancy

1992 • 50 citations

Maintenance infliximab for Crohn's disease

2002 • 43 citations

Adult onset Still's disease: response to Enbrel

2002 • 36 citations

Impaired tumour necrosis factor-α (TNF-α) production and abnormal B cell response to TNF-α in patients with systemic lupus erythematosus (SLE)

1991 • 35 citations

Induction of antinuclear antibodies in patients with rheumatoid arthritis receiving treatment with human recombinant interferon gamma.

1988 • 33 citations

Autoantibodies in Multiple Sclerosis Patients Before and During IFN-β1b Treatment: Are They Correlated with the Occurrence of Autoimmune Diseases?

2002 • 32 citations

Etanercept in the treatment of psoriatic arthritis and psoriasis

2000 • 27 citations

Modification of Hepatitis B Virus Infection by Recombinant Leukocyte Alpha A Interferon

1986 • 24 citations

Myositis associated with interleukin-2 therapy in a patient with metastatic renal cell carcinoma

1995 • 23 citations

Incomplete Reiter's syndrome induced by systemic interferon α treatment

1993 • 23 citations

Phase III study of intermittent carmustine (BCNU), cyclophosphamide, and prednisone versus intermittent melphalan and prednisone in myeloma.

1982 • 23 citations

Rapid exacerbation of scleroderma in a patient treated with interleukin 2 and lymphokine activated killer cells for renal cell carcinoma.

1994 • 20 citations

Interferon-α-Induced Human Lupus Inclusions and p36 Protein in Cancer and AIDS

1996 • 9 citations

It is hazardous to treat HIV patients with interferon-α

2000 • 8 citations

Deleted Work

1955 • 0 citations

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