The Function of Steroid Hormone Receptors Is Inhibited by the hsp90-specific Compound Geldanamycin

Current protocols in molecular biology

1988 • 7,584 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Molecular chaperones in cellular protein folding

1996 • 3,540 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

1994 • 1,426 citations

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

1992 • 1,402 citations

The biology of heat shock proteins and molecular chaperones

1994 • 1,203 citations

Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA

1986 • 722 citations

hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures.

1989 • 624 citations

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

1990 • 526 citations

Polyubiquitination and Proteasomal Degradation of the p185c-B-2 Receptor Protein-tyrosine Kinase Induced by Geldanamycin

1996 • 460 citations

Evidence That the 90-kDa Heat Shock Protein Is Necessary for the Steroid Binding Conformation of the L Cell Glucocorticoid Receptor

1989 • 394 citations

The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins.

1986 • 392 citations

Assisting spontaneity: the role of Hsp90 and small Hsps as molecular chaperones

1994 • 382 citations

Transcription factors 3: nuclear receptors.

1995 • 327 citations

Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase.

1996 • 322 citations

Progesterone Receptor Structure and Function Altered by Geldanamycin, an hsp90-Binding Agent

1995 • 291 citations

Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes.

1993 • 287 citations

Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells.

1996 • 259 citations

p185erbB2 Binds to GRP94 in Vivo

1996 • 259 citations

Binding of p23 and hsp90 during assembly with the progesterone receptor.

1995 • 224 citations

Herbimycin A Induces the 20 S Proteasome- and Ubiquitin-dependent Degradation of Receptor Tyrosine Kinases

1995 • 194 citations

Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes.

1994 • 190 citations

Geldanamycin selectively destabilizes and conformationally alters mutated p53.

1995 • 185 citations

A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1.

1988 • 173 citations

Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A

1988 • 166 citations

Reconstitution of the Steroid Receptor·hsp90 Heterocomplex Assembly System of Rabbit Reticulocyte Lysate

1996 • 160 citations

Tyrosine Aminotransferase

1967 • 128 citations

Monoclonal antibodies to the rat liver glucocorticoid receptor.

1982 • 113 citations

The transformed glucocorticoid receptor has a lower steroid-binding affinity than the nontransformed receptor

1990 • 103 citations

Protein components of the nonactivated glucocorticoid receptor.

1991 • 83 citations

Ornithine Decarboxylase- and ras-Induced Cell Transformations: Reversal by Protein Tyrosine Kinase Inhibitors and Role of pp130^CAS

1995 • 81 citations

Chemical cross-linking of heteromeric glucocorticoid receptors

1988 • 64 citations

Subunit structure of the nonactivated human estrogen receptor.

1995 • 64 citations

Effects of tyrosine kinase inhibitors on the proliferation of human breast cancer cell lines and proteins important in the RAS signaling pathway

1996 • 61 citations

Prevention of anti-CD3 monoclonal antibody-induced thymic apoptosis by protein tyrosine kinase inhibitors.

1994 • 57 citations

Function/Activity of Specific Amino Acids in Glucocorticoid Receptors

1994 • 51 citations

Mechanism of action of a steroidal antiglucocorticoid in lymphoid cells.

1990 • 49 citations

A bacterially expressed mineralocorticoid receptor is associated in vitro with the 90-kilodalton heat shock protein and shows typical hormone- and DNA-binding characteristics

1993 • 41 citations

Association of the 90-kDa heat shock protein does not affect the ligand-binding ability of androgen receptor

1992 • 41 citations

Herbimycin A inhibits the association of p60v-src with the cytoskeletal structure and with phosphatidylinositol 3' kinase.

1993 • 32 citations

Regulation of expression of mouse mammary tumor virus through sequences located in the hormone response element: involvement of cell-cell contact and a negative regulatory factor

1993 • 29 citations

Stress-inducible cellular responses

1997 • 27 citations

Conversion of epidermal growth factor (EGF) into a stimulatory ligand for A431-cell growth by herbimycin A by decreasing the level of expression of EGF receptor

1994 • 24 citations

Subunit dissociation and activation of wild-type and mutant glucocorticoid receptors

1987 • 22 citations

Cloning and expression of a mouse cDNA encoding p59, an immunophilin that associates with the glucocorticoid receptor

1993 • 19 citations

Recent advances in steroid hormone action

1988 • 18 citations

In vivo antitumor activity of herbimycin A, a tyrosine kinase inhibitor, targeted against BCR/ABL oncoprotein in mice bearing BCR/ABL-transfected cells

1994 • 17 citations

Kinetics of glucocorticoid interaction with wild‐type and variant receptors

1982 • 10 citations