p53 Gene status in relation to ex vivo chemosensitivity of non-small cell lung cancer

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

p53 and Human Cancer: The First Ten Thousand Mutations

1999 • 968 citations

Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

1999 • 441 citations

The p53 Gene in Breast Cancer: Prognostic Value of Complementary DNA Sequencing Versus Immunohistochemistry

1996 • 387 citations

Progress in understanding the molecular pathogenesis of human lung cancer

1998 • 291 citations

Chemosensitivity testing of human tumors using a microplate adenosine triphosphate luminescence assay: clinical correlation for cisplatin resistance of ovarian carcinoma.

1995 • 272 citations

The international system for staging lung cancer

2000 • 219 citations

DNA sequence analysis of exons 2 through 11 and immunohistochemical staining are required to detect all known p53 alterations in human malignancies.

1996 • 211 citations

Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer.

1995 • 197 citations

Review of the Efficacy of Individualized Chemotherapy Selected by In Vitro Drug Sensitivity Testing for Patients With Cancer

1999 • 110 citations

Correlation of Drug Response with the ATP Tumorchemosensitivity Assay in Primary FIGO Stage III Ovarian Cancer

2000 • 96 citations

Response and determinants of sensitivity to paclitaxel in human non-small cell lung cancer tumors heterotransplanted in nude mice.

2000 • 82 citations

p53 gene status modulates the chemosensitivity of non-small cell lung cancer cells

2000 • 74 citations

Drug resistance in lung cancer

1999 • 71 citations

The tp53 genotype but not immunohistochemical result is predictive of response to cisplatin-based neoadjuvant therapy in stage III non–small cell lung cancer

1999 • 60 citations

The utility of p53 immunostaining of transbronchial biopsy specimens of lung cancer: p53 overexpression predicts poor prognosis and chemoresistance in advanced non-small cell lung cancer.

1997 • 55 citations

Molecular markers for the diagnosis and prognosis of lung cancer

1992 • 54 citations

Expression of the p53 Tumor Suppressor Gene Product Is a Determinant of Chemosensitivity

1994 • 45 citations

Predictive molecular markers in non–small cell lung cancer

2001 • 42 citations

Expression of p53 and Glutathione S-Transferase-π Relates to Clinical Drug Resistance in Non-Small Cell Lung Cancer

1999 • 38 citations

In vivo influence of p53 status on proliferation and chemoradiosensitivity in non-small-cell lung cancer

1998 • 29 citations

p53 Status Predicts the Efficacy of Postoperative Oral Administration of Tegafur for Completely Resected Non‐small Cell Lung Cancer^†

1999 • 27 citations

Cisplatin-based chemotherapy for postoperative recurrence in non-small cell lung cancer patients: Relation of the in vitro chemosensitive test to clinical response

2001 • 25 citations

Complete sequence of p53 gene in 20 patients with lung cancer: comparison with chemosensitivity and immunohistochemistry

1998 • 24 citations

p53-regulated GML gene expression in non-small cell lung cancer

2000 • 14 citations

Expression and Mutation of p53 in Tumor Effusion Cells of Patients with Ovarian Carcinoma: Response to Cisplatin-Based Chemotherapy

2001 • 13 citations

Overview of Currently Used Chemosensitivity Test Systems in Gynecologic Malignancies and Breast Cancer

1994 • 12 citations

Analysis of the immunoreactivity of three anti-p53 antibodies and estimation of the relations between p53 status and MDM2 protein expression in ovarian carcinomas.

2000 • 12 citations

Chemosensitivity Testing in Gynecologic Malignancies and Breast Cancer

1994 • 12 citations

Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay.

2000 • 11 citations

c-myc oncogene gene dosage, serum CEA and CA-15.3 antigen levels, and cellular DNA values in relation to ex vivo chemosensitivity of primary human breast cancer.

2000 • 4 citations