p53 gene status modulates the chemosensitivity of non-small cell lung cancer cells

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

p53 function and dysfunction

1992 • 1,918 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

1997 • 872 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene.

1994 • 465 citations

P53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features

1992 • 448 citations

Accumulation of p53 protein correlates with a poor prognosis in human lung cancer.

1992 • 384 citations

Mutations of the p53 Gene as a Predictor of Poor Prognosis in Patients With Non-Small-Cell Lung Cancer

1993 • 213 citations

MDR1 Gene Expression in Lung Cancer

1989 • 182 citations

Adenoviral-mediated wild-type p53 gene expression sensitizes colorectal cancer cells to ionizing radiation.

1996 • 180 citations

Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung

1993 • 180 citations

p53 mutations in human lung tumors.

1992 • 177 citations

Correlation of Intrinsic Chemoresistance of Non-Small-Cell Lung Cancer Cell Lines With HER-2/neu Gene Expression but Not With ras Gene Mutations

1993 • 170 citations

To pop or not to pop: p53 as a critical modulator of tumour responsiveness to therapy in vivo?

1995 • 168 citations

p53 involvement in control of G2 exit of the cell cycle: role in DNA damage-induced apoptosis.

1995 • 147 citations

Heterogeneity of transcriptional activity of mutant p53 proteins and p53 DNA target sequences.

1993 • 110 citations

No germline TP53 mutations detected in familial and bilateral testicular cancer

1993 • 84 citations

Novel DNA binding of p53 mutants and their role in transcriptional activation.

1993 • 65 citations

Mechanisms of drug resistance in human lung cancer cells.

1993 • 42 citations

Expression of wild-type p53 increases etoposide cytotoxicity in M1 myeloid leukemia cells by facilitated G2 to M transition: implications for gene therapy.

1997 • 42 citations

Infrequent mutations in the P53 gene in primary human T-cell acute lymphoblastic leukemia.

1991 • 35 citations

Mutant p53 proteins have diverse intracellular abilities to oligomerize and activate transcription.

1993 • 32 citations