The utility of p53 immunostaining of transbronchial biopsy specimens of lung cancer: p53 overexpression predicts poor prognosis and chemoresistance in advanced non-small cell lung cancer.

Reporting results of cancer treatment

1981 • 7,916 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Mechanism of action of taxol

1992 • 730 citations

Chemotherapy can prolong survival in patients with advanced non-small-cell lung cancer--report of a Canadian multicenter randomized trial.

1988 • 704 citations

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1996 • 654 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

p53 mutations increase resistance to ionizing radiation.

1993 • 573 citations

Analysis of Events Associated With Cell Cycle Arrest at G2 Phase and Cell Death Induced by Cisplatin

1990 • 447 citations

Accumulation of p53 protein correlates with a poor prognosis in human lung cancer.

1992 • 384 citations

Hydrated autoclave pretreatment enhances tau immunoreactivity in formalin-fixed normal and Alzheimer's disease brain tissues.

1991 • 316 citations

A comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinoma.

1996 • 277 citations

High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors

1993 • 207 citations

Increased accumulation of p53 protein in cisplatin‐resistant ovarian cell lines

1993 • 203 citations

The p53 gene is very frequently mutated in small-cell lung cancer with a distinct nucleotide substitution pattern

1992 • 199 citations

Mechanism of action of cis-dichlorodiammineplatinum(II).

1979 • 173 citations

Immunohistochemical study of p53 in human lung carcinomas.

1993 • 103 citations

Accumulation of p53 Protein as a Possible Predictor of Response to Adjuvant Combination Chemotherapy With Cyclophosphamide, Methotrexate, Fluorouracil, and Prednisone for Breast Cancer

1995 • 100 citations

Management of small-cell cancer of the lung

1992 • 84 citations

Non-Small-Cell Lung Cancer (NSCLC)

1992 • 6 citations