Expression of p53 and Glutathione S-Transferase-π Relates to Clinical Drug Resistance in Non-Small Cell Lung Cancer

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

WHO Handbook for Reporting Results of Cancer Treatment

1982 • 2,214 citations

Glutathione metabolism and its selective modification.

1988 • 1,975 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

1996 • 734 citations

Chemotherapy can prolong survival in patients with advanced non-small-cell lung cancer--report of a Canadian multicenter randomized trial.

1988 • 704 citations

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene.

1994 • 465 citations

Prospective clinical trial of a human tumor cloning system.

1983 • 340 citations

Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues

1990 • 238 citations

Relationship of p53, bcl-2, and Tumor Proliferation to Clinical Drug Resistance in Non-Hodgkin's Lymphomas

1997 • 230 citations

Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer.

1995 • 197 citations

Primary chemotherapy in breast invasive carcinoma: predictive value of the immunohistochemical detection of hormonal receptors, p53, c-erbB-2, MiB1, pS2 and GST pi

1996 • 196 citations

To pop or not to pop: p53 as a critical modulator of tumour responsiveness to therapy in vivo?

1995 • 168 citations

Elevation of pi class glutathione S-transferase activity in human breast cancer cells by transfection of the GST pi gene and its effect on sensitivity to toxins.

1989 • 164 citations

bcl-2, p53, and response to tamoxifen in estrogen receptor-positive metastatic breast cancer: a Southwest Oncology Group study.

1997 • 145 citations

Prognostic significance of abnormal p53 accumulation in primary, resected non-small-cell lung cancers.

1996 • 133 citations

Chemosensitivity testing of human solid tumors. A review of 1582 assays with 258 clinical correlations

1984 • 131 citations

A randomized trial of alternating chemotherapy versus best supportive care in advanced non-small-cell lung cancer

1992 • 124 citations

The mutational status of p53 protein in gastric and esophageal adenocarcinoma cell lines predicts sensitivity to chemotherapeutic agents

1995 • 91 citations

Immunohistochemical expression of glutathione S-transferase-π can predict chemotherapy response in patients with nonsmall cell lung carcinoma

1996 • 71 citations

Immunohistochemically detected p53 and P-glycoprotein predict the response to chemotherapy in lung cancer

1998 • 55 citations

The utility of p53 immunostaining of transbronchial biopsy specimens of lung cancer: p53 overexpression predicts poor prognosis and chemoresistance in advanced non-small cell lung cancer.

1997 • 55 citations

Expression of glutathione s-transferasepi and sensitivity of human gastric cancer cells to cisplatin

1994 • 50 citations

Expression of the glutathione S-transferase placental form in human lung carcinomas

1988 • 50 citations

Pretreatment minimal staging and prognostic factors for non-small cell lung cancer

1997 • 46 citations

Hepsulfam sensitivity in human breast cancer cell lines: the role of glutathione and glutathione S-transferase in resistance.

1992 • 29 citations

Immunohistochemical Expression of Glutathione S‐Transferase π (GST‐π) and Chemotherapy Response in Malignant Ovarian Tumors

1995 • 20 citations

Glutathione derivatives enhance adriamycin cytotoxicity in a human lung adenocarcinoma cell line.

1997 • 10 citations

Immunohistochemical expression of glutathione S‐transferase‐π can predict chemotherapy response in patients with nonsmall cell lung carcinoma

1996 • 2 citations