p53-regulated GML gene expression in non-small cell lung cancer

Revisions in the International System for Staging Lung Cancer

1997 • 4,582 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials

1995 • 2,804 citations

Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomised clinical trials

1996 • 2,541 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

p53 function and dysfunction

1992 • 1,918 citations

GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases

1991 • 848 citations

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1996 • 654 citations

Mutations of the p53 Gene as a Predictor of Poor Prognosis in Patients With Non-Small-Cell Lung Cancer

1993 • 213 citations

Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer.

1995 • 197 citations

Chemotherapy in non-small cell lung cancer

1995 • 156 citations

The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion.

1995 • 135 citations

Prognostic significance of abnormal p53 accumulation in primary, resected non-small-cell lung cancers.

1996 • 133 citations

Microtubule-active drugs taxol, vinblastine, and nocodazole increase the levels of transcriptionally active p53.

1995 • 120 citations

Characterization of two novel Ly-6 genes. Protein sequence and potential structural similarity to alpha-bungarotoxin and other neurotoxins.

1993 • 114 citations

Cisplatin, camptothecin, and taxol sensitivities of cells with p53-associated multidrug resistance.

1996 • 108 citations

Expression of the multidrug resistance-associated protein (MRP) gene in non-small-cell lung cancer

1995 • 107 citations

An in vitro chemosensitivity test for solid human tumors using collagen gel droplet embedded cultures

1997 • 87 citations

Immunohistochemical expression of glutathione S-transferase-π can predict chemotherapy response in patients with nonsmall cell lung carcinoma

1996 • 71 citations

Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein.

1992 • 66 citations

p53 in life and death.

1996 • 62 citations

Isolation of a novel GPI-anchored gene specifically regulated by p53; correlation between its expression and anti-cancer drug sensitivity.

1996 • 55 citations

The utility of p53 immunostaining of transbronchial biopsy specimens of lung cancer: p53 overexpression predicts poor prognosis and chemoresistance in advanced non-small cell lung cancer.

1997 • 55 citations

Paclitaxel (Taxol) and Docetaxel (Taxotere): active chemotherapeutic agents in lung cancer

1995 • 49 citations

Survival of patients with limited-stage small cell lung cancer treated with individualized chemotherapy selected by in vitro drug sensitivity testing.

1997 • 35 citations

Chemotherapy in the management of patients with inoperable non-small cell lung cancer.

1996 • 34 citations

Development of postoperative intrathoracic chemo-thermotherapy for lung cancer with objective of improving local cure

1989 • 33 citations

Correlation of in vitro drug sensitivity testing results with response to chemotherapy and survival: Comparison of non-small cell lung cancer and small cell lung cancer

1996 • 33 citations

Genomic Structure and Chromosomal Localization of GML (GPI-Anchored Molecule-like Protein), a Gene Induced by p53

1997 • 32 citations

Overexpression of GML Promotes Radiation-Induced Cell Cycle Arrest and Apoptosis

1997 • 27 citations

Immunohistochemical p53 protein status in nonsmall cell lung cancer is a promising indicator in determining in vitro chemosensitivity to some anticancer drugs

1998 • 22 citations

GML sensitizes cancer cells to Taxol by induction of apoptosis

1997 • 21 citations

DRUG SENSITIVITY TEST FOR PRIMARY CULTURE OF HUMAN CANCER-CELLS USING COLLAGEN GEL EMBEDDED CULTURE AND IMAGE-ANALYSIS

1993 • 20 citations

In vitro chemosensitivity testing of human tumours by collagen gel droplet culture and image analysis.

1996 • 16 citations

Detection of the multidrug resistance marker P-glycoprotein by immunohistochemistry in malignant lung tumours.

1996 • 16 citations

INCREASED EXPRESSION OF BCL-2 IN DRUG-RESISTANT SQUAMOUS-CELL LUNG CARCINOMAS

1995 • 13 citations

<b>A SENSITIVE AND HIGH-RESOLUTION METHOD FOR THE DETECTION OF MUTATIONS IN THE p53 GENE USING FLUORESCENCE-BASED </b><b>PCR-SSCP </b>

1995 • 11 citations

The North American experience with paclitaxel combined with cisplatin or carboplatin in lung cancer.

1996 • 11 citations

Increased expression of Bcl-2 in drug-resistant squamous cell lung carcinomas

1996 • 2 citations