Response and determinants of sensitivity to paclitaxel in human non-small cell lung cancer tumors heterotransplanted in nude mice.

Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines

1991 • 3,158 citations

bcl-2 Protein in Non-Small-Cell Lung Carcinoma

1993 • 684 citations

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1996 • 654 citations

Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes.

1997 • 590 citations

Phase II Study of Taxol in Patients With Untreated Advanced Non-Small-Cell Lung Cancer

1993 • 441 citations

Overexpression of ErbB2 Blocks Taxol-Induced Apoptosis by Upregulation of p21Cip1, which Inhibits p34Cdc2 Kinase

1998 • 354 citations

Phase II Study of Taxol, Merbarone, and Piroxantrone in Stage IV Non-Small-Cell Lung Cancer: The Eastern Cooperative Oncology Group Results

1993 • 346 citations

Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents.

1996 • 298 citations

Relationship of Mitotic Arrest and Apoptosis to Antitumor Effect of Paclitaxel

1996 • 290 citations

Transplantation of Human Tumors in Nude Mice23

1976 • 265 citations

Phosphorylation of Bcl-2 Is a Marker of M Phase Events and Not a Determinant of Apoptosis

1998 • 225 citations

Kinetics of mitotic arrest and apoptosis in murine mammary and ovarian tumors treated with taxol

1995 • 185 citations

p53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel.

1997 • 148 citations

Bcl-2–Mediated Drug Resistance

1999 • 147 citations

Overexpression of both p185c-erbB2 and p170mdr-1 renders breast cancer cells highly resistant to taxol

1998 • 124 citations

Amplification and expression of a cellular oncogene (c-myc) in human gastric adenocarcinoma cells.

1985 • 117 citations

Phase II trial of a 3-hour infusion of paclitaxel in previously untreated patients with advanced non-small-cell lung cancer.

1996 • 72 citations

Heterotransplantation of human breast carcinomas in nude mice. Correlation between successful heterotransplants, poor prognosis and amplification of the her‐2/neu oncogene

1991 • 62 citations

Phase II study of 3-hour infusion of paclitaxel in previously untreated non-small cell lung cancer.

1996 • 60 citations

Metastatic potential of human colorectal carcinomas implanted into nude mice: prediction of clinical outcome in patients operated upon for cure.

1989 • 41 citations

Engraftment of human tumor-infiltrating lymphocytes and the production of anti-tumor antibodies in SCID mice.

1996 • 37 citations

Human renal cell carcinoma xenografts in SCID mice: tumorigenicity correlates with a poor clinical prognosis.

1999 • 32 citations

Growth of human bronchial carcinomas in nude mice

1985 • 32 citations

Paclitaxel sensitivity correlates with P53 status and DNA fragmentation, but not G2/M accumulation

1999 • 30 citations

Prognostic Significance of T-Lineage Leukemic Cell Growth in SCID Mice: A Children's Cancer Group Study

1999 • 21 citations

Tumorigenicity of cerebellar primitive neuro-ectodermal tumors in athymic mice correlates with poor prognosis in children

1996 • 19 citations

Prognostic significance of growth characteristics of xenotransplanted ovarian carcinomas into nude mice

1986 • 14 citations

Growth of xenografted squamous cell carcinoma of the head and neck ‐ possible correlation with patient survival

1992 • 10 citations

Correlation between successful heterotransplantation of lung tumors in nude mice, poor prognosis of patients and expression of Fos, Jun, ErbB1, and Ras.

1993 • 6 citations

Evidence of a direct relationship between the increase in the in vitro passage number of human non-small-cell-lung cancer primocultures and their chemosensitivity

1994 • 5 citations

Transplantation of human osteosarcoma into nude mouse--correlation between experiment results and prognosis of patients.

1986 • 5 citations

Clinical prognostic relevance of growth of human adenocarcinomas of the lung in nude mice

1989 • 4 citations

Xenotransplantability of human squamous cell lung cancer in nude mice is not affected by angiogenic factors.

1999 • 3 citations