Model for alternative RNA processing in human calcitonin gene expression

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.

1977 • 2,408 citations

Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing

1983 • 2,298 citations

Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products

1982 • 2,114 citations

Transcription termination and 3′ processing: the end is in site!

1985 • 1,482 citations

Hybridization of nucleic acids immobilized on solid supports

1984 • 1,357 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

Variety in the level of gene control in eukaryotic cells

1982 • 772 citations

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

1984 • 761 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

Steps in the processing of Ad2 mRNA: Poly(A)+ Nuclear sequences are conserved and poly(A) addition precedes splicing

1978 • 478 citations

Lariat RNA's as Intermediates and Products in the Splicing of Messenger RNA precursors

1984 • 474 citations

Isolation and characterization of human calcitonin gene-related peptide

1984 • 420 citations

Intron sequences involved in lariat formation during pre-mRNA splicing

1985 • 402 citations

A second human calcitonin/CGRP gene

1985 • 363 citations

Intron splicing: a conserved internal signal in introns of animal pre-mRNAs.

1984 • 342 citations

Accurate cleavage and polyadenylation of exogenous RNA substrate

1985 • 334 citations

The synthesis and processing of the messenger RNAs specifying heavy and light chain immunoglobulins in MPC-11 cells

1978 • 324 citations

Splicing of in vitro synthesized messenger RNA precursors in HeLa cell extracts

1983 • 255 citations

The complete sequence of human preprocalcitonin

1984 • 235 citations

In vivo splicing products of the rabbit β-globin pre-mRNA

1984 • 209 citations

Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites.

1984 • 202 citations

Characterization of productive and sterile transcripts from the immunoglobulin heavy-chain locus: processing of micron and muS mRNA.

1983 • 165 citations

Poly(A) site cleavage in a HeLa nuclear extract is dependent on downstream sequences

1985 • 152 citations

Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma.

1985 • 151 citations

Report of the committee on the genetic constitution of chromosomes 10, 11, and 12

1987 • 146 citations

Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression.

1985 • 140 citations

Partial nucleotide sequence of human calcitonin precursor mRNA identifies flanking cryptic peptides

1982 • 130 citations

CALCITONIN GENE RELATED PEPTIDE CODING SEQUENCE IS CONSERVED IN THE HUMAN GENOME AND IS EXPRESSED IN MEDULLARY THYROID CARCINOMA

1984 • 110 citations

Regulation of neuroendocrine gene expression by alternative RNA processing. Colocalization of calcitonin and calcitonin gene-related peptide in thyroid C-cells.

1985 • 106 citations

Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide

1984 • 101 citations

Role of an RNA cleavage/poly(A) addition site in the production of membrane-bound and secreted IgM mRNA.

1985 • 93 citations

Structure of late adenovirus 2 heterogeneous nuclear RNA

1979 • 86 citations

Processing of the mouse β-globin mRNA precursor: at least two cleavage-ligation reactions are necessary to excise the larger intervening sequence

1979 • 84 citations

Processing of high molecular weight ovalbumin and ovomucoid precursor RNAs to messenger RNA

1980 • 79 citations

Calcitonin/Calcitonin Gene-Related Peptide Transcription Unit: Tissue-Specific Expression Involves Selective Use of Alternative Polyadenylation Sites

1984 • 73 citations

Characterization of Productive and Sterile Transcripts from the Immunoglobulin Heavy-Chain Locus: Processing of μ_m and μ_s mRNA

1983 • 63 citations

Precursors of alpha and beta globin messenger RNAs

1978 • 62 citations

The orderly splicing of the first three leaders of the adenovirus-2 major late transcript

1982 • 57 citations

Human Medullary Thyroid Carcinoma in Culture Provides a Model Relating Growth Dynamics, Endocrine Cell Differentiation, and Tumor Progression*

1984 • 57 citations

Splicing patterns of nuclear precursors to the mRNA for adenovirus 2 DNA binding protein

1979 • 57 citations

A role for branchpoints in splicing in vivo

1985 • 48 citations

A transcription map for the rabbit β-globin gene

1981 • 47 citations

Cell-specific expression of secreted versus membrane forms of immunoglobulin gamma 2b mRNA involves selective use of alternate polyadenylation sites.

1985 • 46 citations

Production of RNA for secreted immunoglobulin μ chains does not require transcriptional termination 5′ to the μM exons

1983 • 42 citations

Nuclear RNA precursors in the processing pathway to MOPC 21 κ light chain messenger RNA

1979 • 32 citations

The synthesis and processing of a nuclear RNA precursor to rat pregrowth hormone messenger RNA

1979 • 29 citations

The two intervening sequences of human beta- and gamma-globin pre-mRNAs are excised in a preferred temporal order in vitro.

1985 • 28 citations

Ectopic synthesis of high‐M_r calcitonin by the BEN lung carcinoma cell line reflects aberrant proteolytic processing

1986 • 27 citations

Cell-Specific Expression of Secreted Versus Membrane Forms of Immunoglobulin Gamma 2b mRNA Involves Selective Use of Alternate Polyadenylation Sites

1985 • 22 citations

Splicing of the E2A premessenger RNA of adenovirus serotype 2

1986 • 22 citations

Nuclear precursor molecules of the two beta-globin mRNAs in Friend erythroleukemia cells.

1982 • 16 citations

Peptide diversity from exon choice: RNA processing regulation in the neuroendocrine system

1985 • 12 citations

Splicing pathways of the chicken apo very low density lipoprotein II (pre)messenger RNA

1986 • 10 citations