Mitochondrial Ca2+homeostasis in the regulation of apoptotic and necrotic cell deaths

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Apoptosis, oncosis, and necrosis. An overview of cell death.

1995 • 3,325 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 2,326 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

The changing landscape of ischaemic brain injury mechanisms

1999 • 1,111 citations

Decoding of cytosolic calcium oscillations in the mitochondria

1995 • 1,090 citations

Apoptosis

1998 • 806 citations

Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals

1997 • 739 citations

Mitochondrial calcium transport: physiological and pathological relevance

1994 • 702 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 670 citations

Mitochondrial Participation in the Intracellular Ca2+ Network

1997 • 556 citations

Mitochondrial Regulation of Store-operated Calcium Signaling in T Lymphocytes

1997 • 513 citations

The Role of Calcium in the Regulation of Apoptosis

1997 • 460 citations

Pivotal Role of Mitochondrial Calcium Uptake in Neural Cell Apoptosis and Necrosis

1999 • 352 citations

Mitochondrial Depolarization Accompanies Cytochrome cRelease During Apoptosis in PC6 Cells

1999 • 347 citations

A Reevaluation of the Role of Mitochondria in Neuronal Ca²⁺ Homeostasis

1996 • 347 citations

Molecular Mechanisms of Developmental Neuronal Death

1993 • 330 citations

Mitochondrial Ca2+ homeostasis in intact cells.

1994 • 320 citations

Physiological effectors modify voltage sensing by the cyclosporin A-sensitive permeability transition pore of mitochondria.

1993 • 315 citations

Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors.

1996 • 300 citations

Functional Consequences of the Sustained or Transient Activation by Bax of the Mitochondrial Permeability Transition Pore

1999 • 295 citations

Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition

1998 • 294 citations

Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A

1991 • 261 citations

Roles of cytoplasmic Ca2+ and intracellular Ca2+ stores in induction and suppression of apoptosis in S49 cells

1997 • 167 citations

Cyclosporin inhibits mitochondrial calcium efflux in isolated adult rat ventricular cardiomyocytes

1992 • 132 citations

Mitochondrial calcium transporting pathways during hypoxia and reoxygenation in single rat cardiomyocytes

1998 • 116 citations

Modulation of Mitochondrial Ca2+ Homeostasis by Bcl-2

1999 • 112 citations

Alterations of Extracellular Calcium Elicit Selective Modes of Cell Death and Protease Activation in SH‐SY5Y Human Neuroblastoma Cells

1999 • 85 citations

Cyclosporin A Rescues Thymocytes from Apoptosis Induced by Very Low Concentrations of Thapsigargin: Effects on Mitochondrial Function

1996 • 72 citations

Endogenous Bax Translocation in SH‐SY5Y Human Neuroblastoma Cells and Cerebellar Granule Neurons Undergoing Apoptosis

1999 • 60 citations

Suppression of programmed neuronal death by a thapsigargin‐induced Ca²⁺ influx

1995 • 58 citations

Roles of calcium in the regulation of apoptosis in HL-60 promyelocytic leukemia cells

1995 • 56 citations

Calcium chelators induce apoptosis — evidence that raised intracellular ionised calcium is not essential for apoptosis

1994 • 56 citations

Altered inotropic response to IGF-I in diabetic rat heart: influence of intracellular Ca²⁺and NO

1998 • 52 citations

Reduced Capacitative Calcium Entry Correlates with Vesicle Accumulation and Apoptosis

1999 • 38 citations

Intracellular Calcium Stores Are Not Required for Bcl-2-mediated Protection from Apoptosis

1996 • 36 citations

Clonazepam and diltiazem both inhibit sodium-calcium exchange of mitochondria, but only diltiazem inhibits the slow action potentials of cardiac muscles

1985 • 27 citations