Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

1995 • 5,025 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Cross-Talk between Two Cysteine Protease Families

2000 • 1,158 citations

Ca ²⁺ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD

1999 • 1,136 citations

Neurotoxicity induces cleavage of p35 to p25 by calpain

2000 • 1,031 citations

Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin

1998 • 892 citations

Calcium-activated neutral protease (calpain) system: structure, function, and regulation.

1991 • 841 citations

Generic Signals and Specific Outcomes

1999 • 732 citations

Calpain: new perspectives in molecular diversity and physiological‐pathological involvement

1994 • 673 citations

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.

1993 • 575 citations

The calpain family and human disease

2001 • 465 citations

Calpain-dependent Proteolytic Cleavage of the p35 Cyclin-dependent Kinase 5 Activator to p25

2000 • 378 citations

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

1997 • 368 citations

Inhibition of proteolysis protects hippocampal neurons from ischemia.

1991 • 363 citations

Apoptosis of T Cells Mediated by Ca ²⁺ -Induced Release of the Transcription Factor MEF2

1999 • 262 citations

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.

1995 • 260 citations

Six-Hour Window of Opportunity for Calpain Inhibition in Focal Cerebral Ischemia in Rats

1998 • 246 citations

Cabin 1, A Negative Regulator for Calcineurin Signaling in T Lymphocytes

1998 • 235 citations

Cain, A Novel Physiologic Protein Inhibitor of Calcineurin

1998 • 232 citations

Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat.

1996 • 223 citations

Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis

2000 • 216 citations

Proapoptotic Effects of Tau Cleavage Product Generated by Caspase-3

2001 • 206 citations

Calcineurin-Mediated BAD Dephosphorylation Activates the Caspase-3 Apoptotic Cascade in Traumatic Spinal Cord Injury

2000 • 196 citations

Calpain, an upstream regulator of thymocyte apoptosis.

1997 • 191 citations

Substrate specificity of the protein tyrosine phosphatases.

1993 • 189 citations

High Level Calcineurin Activity Predisposes Neuronal Cells to Apoptosis

1999 • 174 citations

Cabin1 Represses MEF2-Dependent Nur77 Expression and T Cell Apoptosis by Controlling Association of Histone Deacetylases and Acetylases with MEF2

2000 • 156 citations

Chapter 3 Assays for DNA Fragmentation, Endonucleases, and Intracellular pH and Ca2+ Associated with Apoptosis

1995 • 128 citations

Calpain Dissociates into Subunits in the Presence Ions

1995 • 95 citations

Calcineurin Is Downstream of the Inositol 1,4,5-Trisphosphate Receptor in the Apoptotic and Cell Growth Pathways

2000 • 92 citations

m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains

1998 • 89 citations

Neuronal Nitric Oxide Synthase and Calmodulin‐Dependent Protein Kinase IIα Undergo Neurotoxin‐Induced Proteolysis

1997 • 80 citations

Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia

1998 • 74 citations

The Calcineurin-binding Protein Cain Is a Negative Regulator of Synaptic Vesicle Endocytosis

2000 • 65 citations

Calpain inhibitor entrapped in liposome rescues ischemic neuronal damage

1999 • 60 citations

A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus

2001 • 60 citations

Calcium-activated neutral protease inhibitor(E-64c) and reperfusion for experimental myocardial infarction.

1989 • 18 citations

Suppression of Interleukin-1β converting enzyme (ICE)-induced apoptosis by SV40 large T antigen

1997 • 17 citations

Calpain expression varies among different rat and bovine central nervous system regions

1998 • 10 citations