Patterning motoneurons in the vertebrate nervous system

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Homeobox genes and axial patterning

1992 • 2,688 citations

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

1993 • 1,086 citations

Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm

1995 • 1,060 citations

Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling

1997 • 1,019 citations

Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes

1994 • 1,005 citations

Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

1996 • 866 citations

Segmental patterns of neuronal development in the chick hindbrain

1989 • 840 citations

Identification of neurogenin, a Vertebrate Neuronal Determination Gene

1996 • 821 citations

Requirement for LIM Homeobox Gene Isl1 in Motor Neuron Generation Reveals a Motor Neuron– Dependent Step in Interneuron Differentiation

1996 • 774 citations

The neurotrophic factor concept: a reexamination

1993 • 745 citations

Diversity and Pattern in the Developing Spinal Cord

1996 • 714 citations

Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta

1995 • 669 citations

Zebrafish organizer development and germ-layer formation require nodal-related signals

1998 • 657 citations

mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans

1988 • 573 citations

Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis

1997 • 561 citations

Patterning activities of vertebrate hedgehog proteins in the developing eye and brain

1995 • 557 citations

The world according to bedgebog

1997 • 549 citations

Mechanisms and Molecules that Control Growth Cone Guidance

1996 • 515 citations

Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system

1998 • 497 citations

Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate

1993 • 470 citations

Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling

1998 • 458 citations

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice

1998 • 448 citations

LIM Homeodomain Factors Lhx3 and Lhx4 Assign Subtype Identities for Motor Neurons

1998 • 438 citations

The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system

1991 • 432 citations

Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1

1996 • 410 citations

The neurotrophic theory and naturally occurring motoneuron death

1989 • 397 citations

Motor Neuron–Derived Retinoid Signaling Specifies the Subtype Identity of Spinal Motor Neurons

1998 • 383 citations

Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos

1993 • 366 citations

cyclops encodes a nodal-related factor involved in midline signaling

1998 • 360 citations

Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord

1993 • 356 citations

Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish

1998 • 355 citations

Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.

1996 • 351 citations

Specification of Motor Neuron Identity by the MNR2 Homeodomain Protein

1998 • 340 citations

Functionally Related Motor Neuron Pool and Muscle Sensory Afferent Subtypes Defined by Coordinate ETS Gene Expression

1998 • 328 citations

Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord

1993 • 326 citations

Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish

1996 • 320 citations

A LIM-homeodomain combinatorial code for motor-neuron pathway selection

1999 • 294 citations

Motoneuron fate specification revealed by patterned LIM homeobox gene expression in embryonic zebrafish

1995 • 290 citations

Mutations affecting development of the midline and general body shape during zebrafish embryogenesis

1996 • 287 citations

The Drosophila islet Gene Governs Axon Pathfinding and Neurotransmitter Identity

1997 • 283 citations

Neurotrophic Survival Molecules for Motoneurons: An Embarrassment of Riches

1996 • 271 citations

Multiple delta genes and lateral inhibition in zebrafish primary neurogenesis

1998 • 268 citations

Zebrafish primary neurons initiate expression of the LIM homeodomain protein Isl-1 at the end of gastrulation

1993 • 252 citations

Restricted Expression of a Novel Murineatonal-Related bHLH Protein in Undifferentiated Neural Precursors

1996 • 252 citations

The activity of Neurogenin1 is controlled by local cues in the zebrafish embryo

1997 • 244 citations

Developmental regulation of Islet‐1 mRNA expression during neuronal differentiation in embryonic zebrafish

1994 • 236 citations

Pax-6 is involved in the specification of hindbrain motor neuron subtype

1997 • 217 citations

Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning

1997 • 211 citations

Mash1andneurogenin1Expression Patterns Define Complementary Domains of Neuroepithelium in the Developing CNS and Are Correlated with Regions Expressing Notch Ligands

1997 • 210 citations

Motoneurone projection patterns in the chick hind limb following early partial reversals of the spinal cord.

1980 • 203 citations

Catching a Gli-mpse of Hedgehog

1997 • 198 citations

Reprogramming Hox Expression in the Vertebrate Hindbrain: Influence of Paraxial Mesoderm and Rhombomere Transposition

1996 • 193 citations

Control of neuronal pathway selection by the Drosophila LIM homeodomain gene apterous

1995 • 189 citations

The control of rostrocaudal pattern in the developing spinal cord: specification of motor neuron subtype identity is initiated by signals from paraxial mesoderm

1998 • 179 citations

Hox homeobox genes and regionalisation of the nervous system

1993 • 170 citations

Regulation of neuronal specification in the zebrafish spinal cord by Delta function

1998 • 157 citations

Differential Expression of LIM Homeobox Genes among Motor Neuron Subpopulations in the Developing Chick Brain Stem

1996 • 153 citations

Development of branchiomotor neurons in zebrafish

1997 • 147 citations

Genetic mechanisms of early neurogenesis inDrosophila melanogaster

1995 • 137 citations

Determination of Primary Motoneuron Identity in Developing Zebrafish Embryos

1991 • 130 citations

Programmed cell death during the earliest stages of spinal cord development in the chick embryo: A possible means of early phenotypic selection

1994 • 126 citations

Increased apoptosis of motoneurons and altered somatotopic maps in the brachial spinal cord of Hoxc-8-deficient mice

1998 • 126 citations

Pathfinding by zebrafish motoneurons in the absence of normal pioneer axons

1992 • 109 citations

Independent assignment of antero-posterior and dorso-ventral positional values in the developing chick hindbrain

1995 • 109 citations

Molecular Heterogeneity among Primary Motoneurons and within Myotomes Revealed by the Differential mRNA Expression of Novel Islet-1 Homologs in Embryonic Zebrafish

1995 • 109 citations

Expression of Activin mRNA during Early Development in Xenopus laevis

1993 • 101 citations

Rhombomere-specific origin of the contralateral vestibulo-acoustic efferent neurons and their migration across the embryonic midline

1993 • 101 citations

Temporal Separation in the Specification of Primary and Secondary Motoneurons in Zebrafish

1997 • 87 citations

Spinal Muscular Atrophy

1998 • 85 citations

Neuronal diversification: development of motor neuron subtypes

1998 • 84 citations

Regulation of vertebrate neural cell fate by transcription factors

1996 • 81 citations

The spt-1 mutation alters segmental arrangement and axonal development of identified neurons in the spinal cord of the embryonic zebrafish

1991 • 78 citations

A critical period for the specification of motor pools in the chick lumbosacral spinal cord

1996 • 72 citations

Delayed formation of the floor plate after ablation of the avian notochord

1993 • 64 citations

Activin A inhibits Pax-6 expression and perturbs cell differentiation in the developing spinal cord in vitro.

1995 • 64 citations

Neural Development: A ‘LIM code’ for motor neurons?

1995 • 59 citations

Vitronectin is expressed in the ventral region of the neural tube and promotes the differentiation of motor neurons

1997 • 57 citations

Development of Motoneuronal Phenotype

1994 • 57 citations

Development and survival of thoracic motoneurons and hindlimb musculature following transplantation of the thoracic neural tube to the lumbar region in the chick embryo: Anatomical aspects

1990 • 56 citations

Environmental Specification of Neuronal Connectivity

1993 • 55 citations

Neurotrophin 3 stimulates the differentiation of motoneurons from avian neural tube progenitor cells.

1994 • 54 citations

Dorsal-Ventral Patterning during Neural Induction inXenopus:Assessment of Spinal Cord Regionalization withxHB9,a Marker for the Motor Neuron Region

1997 • 50 citations

Motoneuron differentiation, survival and synaptogenesis

1997 • 50 citations

Coordination of early neural tube development by BDNF/trkB

1997 • 42 citations

TWH Regulates the Development of Subsets of Spinal Cord Neurons

1997 • 41 citations

From message to mind: Directions in developmental neurobiology

1988 • 40 citations

Nodal signaling and axis formation in the mouse.

1997 • 39 citations

Clinical and molecular aspects of motoneurone diseases: animal models, neurotrophic factors and Bcl-2 oncoprotein

1997 • 33 citations

Regional specification of motoneurons along the anterior-posterior axis is independent of the notochord

1996 • 26 citations

Expression and regulation of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in distinct avian motoneuron subsets

1996 • 16 citations

Virally Mediated Misexpression of Hoxc-6 in the Cervical Mesoderm Results in Spinal Nerve Truncations

1996 • 15 citations

From message to mind: Directions in developmental neurobiology

1989 • 14 citations

Evolution: When was life's first branch point?

1996 • 13 citations

Coexpression of HNF-3 beta and Isl-1/2 and mixed distribution of ventral cell types in the early neural tube.

1996 • 12 citations

Commitment of Motoneuron Progenitors of Chick Embryo along the Anterior-Posterior Axis

1997 • 11 citations