Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Monoclonal Antibody to 5-Bromo- and 5-Iododeoxyuridine: A New Reagent for Detection of DNA Replication

1982 • 2,648 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Pax-6, a murine paired box gene, is expressed in the developing CNS

1991 • 1,226 citations

A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes

1993 • 1,166 citations

Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling

1997 • 1,019 citations

Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes

1994 • 1,005 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.

1991 • 897 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

1996 • 866 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

1994 • 786 citations

A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene

1993 • 715 citations

Diversity and Pattern in the Developing Spinal Cord

1996 • 714 citations

A binding site for Gli proteins is essential for HNF-3β floor plate enhancer activity in transgenics and can respond to Shh in vitro

1997 • 667 citations

Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

1997 • 658 citations

Longitudinal organization of the anterior neural plate and neural tube

1995 • 647 citations

Gli1 is a target of Sonic hedgehog that induces ventral neural tube development

1997 • 625 citations

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development

1997 • 606 citations

A Role for the Roof Plate and Its Resident TGFβ-Related Proteins in Neuronal Patterning in the Dorsal Spinal Cord

1997 • 575 citations

The world according to bedgebog

1997 • 549 citations

GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families

1991 • 549 citations

GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome

1997 • 501 citations

Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants

1995 • 491 citations

Induction of midbrain dopaminergic neurons by Sonic hedgehog

1995 • 481 citations

Expression of Three Mouse Homologs of the Drosophila Segment Polarity Gene cubitus interruptus, Gli, Gli-2, and Gli-3, in Ectoderm- and Mesoderm-Derived Tissues Suggests Multiple Roles during Postimplantation Development

1994 • 478 citations

The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system

1991 • 432 citations

Sonic hedgehog Differentially Regulates Expression ofGLIandGLI3during Limb Development

1996 • 385 citations

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

1996 • 380 citations

Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo

1995 • 376 citations

Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish

1996 • 320 citations

Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus interruptus

1996 • 320 citations

The GLI-Kruppel family of human genes.

1988 • 302 citations

HNF-3β as a regulator of floor plate development

1994 • 287 citations

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling

1997 • 283 citations

Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1

1997 • 275 citations

Pax-6 is involved in the specification of hindbrain motor neuron subtype

1997 • 217 citations

PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development

1997 • 212 citations

Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis

1995 • 200 citations

Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development

1997 • 199 citations

Catching a Gli-mpse of Hedgehog

1997 • 198 citations

Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway

1996 • 176 citations

Role of the floor plate in axonal patterning in the zebrafish CNS

1992 • 169 citations

Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation

1995 • 165 citations

Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt)

1992 • 164 citations

Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice

1997 • 152 citations

Hedgehog and beyond

1995 • 149 citations

Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes

1997 • 140 citations

Early Stages of Notochord and Floor Plate Development in the Chick Embryo Defined by Normal and Induced Expression of HNF-3β

1995 • 119 citations

Multigenic Control of the Localization of the Zone of Polarizing Activity in Limb Morphogenesis in the Mouse

1997 • 115 citations

Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein

1997 • 115 citations

Restrictions to Floor Plate Induction by hedgehog and Winged-Helix Genes in the Neural Tube of Frog Embryos

1995 • 107 citations

The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A.

1991 • 107 citations

Effect of the notochord on proliferation and differentiation in the neural tube of the chick embryo

1989 • 103 citations

gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development

1993 • 95 citations

Enhancer analysis of the mouse HNF‐3β gene: regulatory elements for node/notochord and floor plate are independent and consist of multiple sub‐ elements

1996 • 94 citations

Ectopic neural expression of a floor plate marker in frog embryos injected with the midline transcription factor Pintallavis.

1993 • 87 citations

[23] Detection of messenger RNA by in Situ hybridization to postimplantation embryo whole mounts

1993 • 84 citations

Characterization of a gene trap insertion into a novel gene, cordon‐bleu, expressed in axial structures of the gastrulating mouse embryo

1995 • 68 citations

Inhibition of floor plate differentiation by Pax3: evidence from ectopic expression in transgenic mice

1996 • 55 citations

A role for Xenopus Gli-type zinc finger proteins in the early embryonic patterning of mesoderm and neuroectoderm

1997 • 48 citations

Coexpression of HNF-3 beta and Isl-1/2 and mixed distribution of ventral cell types in the early neural tube.

1996 • 12 citations

Deleted Work

1955 • 0 citations