The possible role of neurotrophins in the pathogenesis and therapy of schizophrenia

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

1987 • 3,683 citations

Neurotrophin signal transduction in the nervous system

2000 • 1,910 citations

Physiology of the Neurotrophins

1996 • 1,908 citations

The neuropathology of schizophrenia

1999 • 1,664 citations

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

1991 • 1,487 citations

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

1990 • 1,261 citations

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

1990 • 1,238 citations

Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

1990 • 1,140 citations

Trk receptors: mediators of neurotrophin action

2001 • 1,051 citations

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

1987 • 1,000 citations

A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity

1996 • 948 citations

p75 and Trk: A two-receptor system

1995 • 861 citations

Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia

2001 • 812 citations

Schizophrenia After Prenatal Famine

1996 • 740 citations

Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.

1990 • 700 citations

Neurotrophin signaling through the p75 neurotrophin receptor

2002 • 686 citations

Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture

1990 • 684 citations

The Subplate, A Transient Neocortical Structure: Its Role in the Development of Connections between Thalamus and Cortex

1994 • 642 citations

Severe sensory and sympathetic deficits in mice lacking neurotrophin-3

1994 • 635 citations

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

1992 • 633 citations

Neurotrophic factors and their receptors

1995 • 583 citations

From neuropathology to neurodevelopment

1995 • 569 citations

Primary structure and biological activity of a novel human neurotrophic factor

1990 • 553 citations

Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells

1986 • 519 citations

Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia

2003 • 517 citations

Human and rat brain-derived neurotrophic factor and neurotrophin-3: Gene structures, distributions, and chromosomal localizations

1991 • 500 citations

Dorsal Root Ganglion Neurons Are Destroyed by Exposure in Utero to Maternal Antibody to Nerve Growth Factor

1980 • 500 citations

Brain-derived neurotrophic factor prevents neuronal death in vivo

1988 • 490 citations

Cortical maldevelopment, anti-psychotic drugs, and schizophrenia: a search for common ground

1995 • 475 citations

BDNF Has Opposite Effects on the Quantal Amplitude of Pyramidal Neuron and Interneuron Excitatory Synapses

1998 • 460 citations

Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death

1992 • 458 citations

Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR

1999 • 452 citations

Early maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampus

2002 • 451 citations

Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions

1984 • 446 citations

Intelligence in Schizophrenia: Meta-analysis of the Research

1984 • 407 citations

Neurotrophin-6 is a new member of the nerve growth factor family

1994 • 404 citations

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

1994 • 402 citations

Schizophrenia after prenatal exposure to 1957 A2 influenza epidemic

1991 • 398 citations

Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons

1986 • 377 citations

Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon

1994 • 374 citations

Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization

1990 • 365 citations

Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses

2001 • 355 citations

Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients

2000 • 340 citations

Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: Lesion effects in the rat brain and levels in Alzheimer's disease

1986 • 335 citations

Characterization of Nerve Growth Factor (NGF) Release from Hippocampal Neurons: Evidence for a Constitutive and an Unconventional Sodium‐dependent Regulated Pathway

1995 • 319 citations

Positive Feedback between Acetylcholine and the Neurotrophins Nerve Growth Factor and Brain‐derived Neurotrophic Factor in the Rat Hippocampus

1994 • 301 citations

Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain

1991 • 295 citations

Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases

1999 • 291 citations

Localization of nerve growth factor receptors in cholinergic neurons of the human basal forebrain

1986 • 289 citations

Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients

2002 • 284 citations

Changes in neurotrophin responsiveness during the development of cerebellar granule neurons

1992 • 240 citations

Antipsychotic drugs: importance of dopamine receptors for mechanisms of therapeutic actions and side effects.

2001 • 235 citations

Axonal growth and fasciculation linked to differential expression of BDNF and NT3 receptors in developing cerebellar granule cells

1995 • 216 citations

Differential Actions of Neurotrophins in the Locus Coeruleus and Basal Forebrain

1993 • 212 citations

Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus

1993 • 204 citations

BDNF mRNA expression in rat hippocampus and prefrontal cortex: effects of neonatal ventral hippocampal damage and antipsychotic drugs

2001 • 197 citations

Schizophrenia: developmental neuroscience and pathobiology

1993 • 196 citations

Postmortem Studies in Schizophrenia

1998 • 187 citations

Brain-derived neurotrophic factor and tyrosine kinase receptor TrkB in rat brain are significantly altered after haloperidol and risperidone administration

2000 • 170 citations

A Prosurvival Function for the p75 Receptor Death Domain Mediated via the Caspase Recruitment Domain Receptor-Interacting Protein 2

2001 • 165 citations

Neurotrophin receptors: mediators of life and death

1998 • 161 citations

Purification and Identification of Brain-Derived Neurotrophic Factor from Human Serum

1995 • 153 citations

The neurotrophins and their receptors: Structure, function, and neuropathology

1994 • 146 citations

Systemic Administration of a Nerve Growth Factor Conjugate Reverses Age-Related Cognitive Dysfunction and Prevents Cholinergic Neuron Atrophy

1996 • 142 citations

An association study of a brain-derived neurotrophic factor Val66Met polymorphism and clozapine response of schizophrenic patients

2003 • 140 citations

Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia are indistinguishable from controls

2003 • 140 citations

Brain-derived neurotrophic factor: subcellular compartmentalization and interneuronal transfer as visualized with anti-peptide antibodies.

1991 • 139 citations

Cloning and Expression of a Novel Neurotrophin, NT-7, from Carp

1998 • 138 citations

Perinatal Risk Factors and Schizophrenia: Selective Review and Methodological Concerns

1995 • 138 citations

COMPARATIVE STUDY OF BRAIN-DERIVED NEUROTROPHIC FACTOR MESSENGER RNA AND PROTEIN AT THE CELLULAR LEVEL SUGGESTS MULTIPLE ROLES IN HIPPOCAMPUS, STRIATUM AND CORTEX

1996 • 137 citations

Evidence for a deficit in cholinergic interneurons in the striatum in schizophrenia

1999 • 135 citations

Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration

2002 • 126 citations

Brain-derived neurotrophic factor and neurotrophin-3 mRNAs are expressed in ventral midbrain regions containing dopaminergic neurons

1992 • 123 citations

Septal cholinergic afferents regulate expression of brain-derived neurotrophic factor andβ-nerve growth factor mRNA in rat hippocampus

1992 • 122 citations

Corticostriatal brain‐derived neurotrophic factor dysregulation in adult rats following prenatal stress

2004 • 121 citations

The nerve growth factor: Thirty-five years later

1987 • 119 citations

Association study of schizophrenia with polymorphisms at six candidate genes

2001 • 117 citations

Intact Implicit Learning in Schizophrenia

2001 • 111 citations

Maternal infection regulates BDNF and NGF expression in fetal and neonatal brain and maternal–fetal unit of the rat

2003 • 104 citations

Glutamate stimulates neurotrophin expression in cultured Müller cells

2003 • 102 citations

Clenbuterol protects mouse cerebral cortex and rat hippocampus from ischemic damage and attenuates glutamate neurotoxicity in cultured hippocampal neurons by induction of NGF

1996 • 102 citations

Immunohistochemical study of brain-derived neurotrophic factor and its receptor, TrkB, in the hippocampal formation of schizophrenic brains

2003 • 101 citations

Nerve growth factor in never-medicated first-episode psychotic and medicated chronic schizophrenic patients: possible implications for treatment outcome

2003 • 96 citations

Ethanol effects on neonatal rat cortex: comparative analyses of neurotrophic factors, apoptosis-related proteins, and oxidative processes during vulnerable and resistant periods

2003 • 96 citations

Heritability of BDNF alleles and their effect on brain morphology in schizophrenia

1999 • 90 citations

Normal β-NGF content in Alzheimer's disease cerebral cortex and hippocampus

1991 • 82 citations

High Resolution Mapping of the Binding Site of TrkA for Nerve Growth Factor and TrkC for Neurotrophin-3 on the Second Immunoglobulin-like Domain of the Trk Receptors

1998 • 78 citations

Olanzapine counteracts reduction of brain-derived neurotrophic factor and TrkB receptors in rat hippocampus produced by haloperidol

2004 • 74 citations

Neurotrophin-4 delivered by fibrin glue promotes peripheral nerve regeneration

2001 • 74 citations

NGF expression in the developing rat brain: effects of maternal separation

2000 • 71 citations

Chromosomal locations of the human and mouse genes for precursors of epidermal growth factor and the beta subunit of nerve growth factor.

1985 • 65 citations

Modulation of nerve growth factor and choline acetyltransferase expression in rat hippocampus after chronic exposure to haloperidol, risperidone, and olanzapine

2004 • 57 citations

Chronic antipsychotic treatment selectively alters nerve growth factor and neuropeptide Y immunoreactivity and the distribution of choline acetyl transferase in rat brain regions

2000 • 57 citations

Changes in the pattern of brain-derived neurotrophic factor immunoreactivity in the rat brain after acute and subchronic haloperidol treatment

2000 • 56 citations

Alterations in neurotrophin and neurotrophin receptor gene expression patterns in the rat central nervous system following perinatal Borna disease virus infection

2000 • 54 citations

Stimulation of β₂-Adrenoceptors Inhibits Apoptosis in Rat Brain after Transient Forebrain Ischemia

1998 • 53 citations

Long-lasting effects of prenatal MAM treatment on water maze performance in rats:

2002 • 50 citations

The conservation of neurotrophic factors during vertebrate evolution

1994 • 49 citations

THE ASSOCIATION BETWEEN SEASON OF BIRTH AND THE RISK FOR SCHIZOPHRENIA

1981 • 45 citations

Haloperidol Administration in Humans Lowers Plasma Nerve Growth Factor Level: Evidence that Sedation Induces Opposite Effects to Arousal

1997 • 45 citations

Association of Neurotrophin-3 Gene Variant with Severe Forms of Schizophrenia

1995 • 44 citations

Neuronal growth factors, neurotrophins and memory deficiency

1995 • 44 citations

Trophic effect of exogenous nerve growth factor on rat striatal cholinergic neurons: comparison between intraparenchymal and intraventricular administration.

1996 • 39 citations

An association study of a neurotrophic3 (NT‐3) gene polymorphism with schizophrenia

1995 • 34 citations

Opposing effects of low and high‐dose clozapine on survival of transgenic amyotrophic lateral sclerosis mice

2003 • 33 citations

Carrier mediated delivery of NGF: alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors.

1997 • 33 citations

Physiological and morphological plasticity induced by chronic treatment with NT-3 or NT-4/5 in hippocampal slice cultures

2002 • 32 citations

Prenatal exposure to methylazoxymethanol acetate in the rat alters neurotrophin levels and behavior: considerations for neurodevelopmental diseases

2000 • 31 citations

Haloperidol treatment decreases nerve growth factor levels in the hypothalamus of adult mice

1996 • 30 citations

Carrier mediated delivery of NGF: Alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors

1997 • 29 citations

Bromodeoxyuridine and methylazoxymethanol exposure during brain development affects behavior in rats: consideration for a role of nerve growth factor and brain derived neurotrophic factor

2001 • 23 citations

Neurotrophin-3 levels in the cerebrospinal fluid of patients with schizophrenia or medical illness

1997 • 22 citations

Expression of Schwann cell-specific proteins and low-molecular-weight neurofilament protein during regeneration of sciatic nerve treated with neurotrophin-4

2001 • 16 citations

Changes in serum levels of autoantibody to nerve growth factor in patients with schizophrenia

1999 • 12 citations

Autoantibodies to nerve growth factor in disorders of mental development in infants.

2001 • 6 citations