4 Stem cell kinetics

Differentiation and proliferation of hematopoietic stem cells

1993 • 1,417 citations

Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.

1995 • 1,223 citations

Isolation of a candidate human hematopoietic stem-cell population.

1992 • 1,098 citations

Hematopoietic commitment during embryonic stem cell differentiation in culture.

1993 • 919 citations

Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy

1996 • 795 citations

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

1989 • 699 citations

Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers.

1990 • 697 citations

Long-term culture of human bone marrow cells.

1980 • 624 citations

The transcriptional control of hematopoiesis [see comments]

1996 • 608 citations

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.

1988 • 602 citations

Cytokine Stimulation of Multilineage Hematopoiesis from Immature Human Cells Engrafted in SCID Mice

1992 • 555 citations

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells.

1994 • 529 citations

The scid mutation in mice causes a general defect in DNA repair

1990 • 525 citations

Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia

1994 • 514 citations

Genetic marking shows that Ph+ cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML

1994 • 502 citations

Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy.

1990 • 456 citations

Functional Isolation and Characterization of Human Hematopoietic Stem Cells

1995 • 414 citations

Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium.

1996 • 393 citations

bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.

1990 • 371 citations

Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function

1995 • 340 citations

Long-Term Marrow Culture Reveals Chromosomally Normal Hematopoietic Progenitor Cells in Patients with Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia

1983 • 335 citations

Chemokine receptors: Structure, function and role in microbial pathogenesis

1996 • 329 citations

Identification in culture of a class of hemopoietic colony-forming units with extensive capability to self-renew and generate multipotential hemopoietic colonies.

1982 • 317 citations

Cytokine manipulation of primitive human hematopoietic cell self-renewal

1997 • 306 citations

Regulation of megakaryocytopoiesis

1989 • 305 citations

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer

1991 • 292 citations

CD34 expression by stromal precursors in normal human adult bone marrow

1991 • 289 citations

Immature human cord blood progenitors engraft and proliferate to high levels in severe combined immunodeficient mice

1994 • 283 citations

Use of limiting-dilution type long-term marrow cultures in frequency analysis of marrow-repopulating and spleen colony-forming hematopoietic stem cells in the mouse

1991 • 267 citations

Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV.

1992 • 263 citations

Differential regulation of primitive human hematopoietic cells in long- term cultures maintained on genetically engineered murine stromal cells

1991 • 261 citations

Kinetic Evidence of the Regeneration of Multilineage Hematopoiesis From Primitive Cells in Normal Human Bone Marrow Transplanted Into Immunodeficient Mice

1997 • 247 citations

Engraftment and long-term expression of human fetal hemopoietic stem cells in sheep following transplantation in utero.

1992 • 243 citations

In Vitro Development of Primitive and Definitive Erythrocytes from Different Precursors

1996 • 240 citations

Enhanced detection, maintenance, and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human steel factor, interleukin-3, and granulocyte colony-stimulating factor

1996 • 234 citations

Long-term erythropoiesis from constant numbers of CD34+ cells in serum-free cultures initiated with highly purified progenitor cells from human bone marrow.

1992 • 231 citations

Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2.

1995 • 207 citations

Phenotype and function of human hematopoietic cells engrafting immune- deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells

1996 • 204 citations

Selection of benign primitive hematopoietic progenitors in chronic myelogenous leukemia on the basis of HLA-DR antigen expression

1992 • 202 citations

Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis

1996 • 196 citations

bcr-abl oncogene renders myeloid cell line factor independent: potential autocrine mechanism in chronic myeloid leukemia.

1988 • 177 citations

Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level.

1992 • 174 citations

Characterization of primitive hematopoietic cells in normal human peripheral blood

1992 • 172 citations

Baillière's clinical haematology

1998 • 168 citations

Normal and leukemic human stem cells assayed in SCID mice

1996 • 163 citations

Growth characteristics of leukemic and normal hematopoietic cells in Ph' + chronic myelogenous leukemia and effects of intensive treatment

1982 • 159 citations

Selection of benign primitive hematopoietic progenitors in chronic myelogenous leukemia on the basis of HLA-DR antigen expression

1992 • 156 citations

Autografting with cultured marrow in chronic myeloid leukemia: results of a pilot study [see comments]

1994 • 153 citations

Blast cell colony assay for umbilical cord blood and adult bone marrow progenitors

1987 • 152 citations

Clonal analysis of proliferation and differentiation of paired daughter cells: action of granulocyte-macrophage colony-stimulating factor on granulocyte-macrophage precursors.

1980 • 147 citations

Clonal analysis of progenitor cell commitment to granulocyte or macrophage production

1982 • 145 citations

Expression of bcr-abl abrogates factor-dependent growth of human hematopoietic M07E cells by an autocrine mechanism

1994 • 140 citations

Amplification of Sca-1+ Lin-WGA+ cells in serum-free cultures containing steel factor, interleukin-6, and erythropoietin with maintenance of cells with long-term in vivo reconstituting potential

1994 • 139 citations

Leukapheresis* by Continuous Flow Centrifugation (CFC) in Patients with Chronic Myelocytic Leukemia (CML)

1969 • 135 citations

Characterization and purification of a primitive hematopoietic cell type in adult mouse marrow capable of lymphomyeloid differentiation in long-term marrow "switch" cultures

1995 • 131 citations

Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1 alpha, an inhibitor of primitive normal hematopoietic cells.

1993 • 125 citations

Clonal Hematopoiesis Demonstrated by X-Linked DNA Polymorphisms after Allogeneic Bone Marrow Transplantation

1989 • 121 citations

Autografting with cultured marrow in chronic myeloid leukemia: results of a pilot study [see comments]

1994 • 121 citations

Characterization of primitive subpopulations of normal and leukemic cells present in the blood of patients with newly diagnosed as well as established chronic myeloid leukemia

1996 • 121 citations

Single cell origin of multilineage colonies in culture. Evidence that differentiation of multipotent progenitors and restriction of proliferative potential of monopotent progenitors are stochastic processes.

1984 • 119 citations

Sustained proliferation, multi‐lineage differentiation and maintenance of primitive human haemopoietic cells in NOD/SCID mice transplanted with human cord blood

1997 • 117 citations

Individual CD34+CD38lowCD19−CD10− Progenitor Cells From Human Cord Blood Generate B Lymphocytes and Granulocytes

1997 • 112 citations

Intensive combination chemotherapy (ROAP 10) and splenectomy in the management of chronic myelogenous leukemia.

1985 • 111 citations

Separation of functionally distinct subpopulations of primitive human hematopoietic cells using rhodamine-123.

1991 • 103 citations

The Use of Cell Markers in The Study of Human Hematopoietic Neoplasia

1987 • 103 citations

COMPLICATION OF BONE-MARROW TRANSPLANTATION GRAFT-VERSUS-HOST DISEASE RESULTING FROM CHRONIC-MYELOGENOUS-LEUKÆMIA LEUCOCYTE TRANSFUSIONS

1970 • 101 citations

Selective Expansion of Primitive Normal Hematopoietic Cells in Cytokine-Supplemented Cultures of Purified Cells From Patients With Chronic Myeloid Leukemia

1997 • 101 citations

Propagation of human blastic myeloid leukemias in the SCID mouse

1992 • 99 citations

Incidence of Leukemia in Atomic Bomb Survivors Belonging to a Fixed Cohort in Hiroshima and Nagasaki, 1950-71 Radiation dose, years after exposure, age at exposure, and type of leukemia

1978 • 97 citations

Highly efficient elimination of Philadelphia leukemic cells by exposure to bcr/abl antisense oligodeoxynucleotides combined with mafosfamide.

1993 • 92 citations

Alternative mechanisms with and without steel factor support primitive human hematopoiesis

1993 • 90 citations

Quantitation of the quiescent fraction of long-term culture-initiating cells in normal human blood and marrow and the kinetics of their growth factor-stimulated entry into S-phase in vitro

1995 • 89 citations

Transforming growth factor beta 1 is an inducer of erythroid differentiation.

1994 • 88 citations

Interferon-alpha restores the deficient expression of the cytoadhesion molecule lymphocyte function antigen-3 by chronic myelogenous leukemia progenitor cells.

1991 • 85 citations

Differentiation-associated changes in CD44 isoform expression during normal hematopoiesis and their alteration in chronic myeloid leukemia

1995 • 85 citations

The role of cells and their products in the regulation of in vitro stem cell proliferation and granulocyte development

1980 • 84 citations

Culture of phenotypically defined hematopoietic stem cells and other progenitors at limiting dilution on Dexter monolayers [see comments]

1991 • 72 citations

Persistent Mitosis of Transfused Homologous Leukocytes in Children Receiving Antileukemic Therapy

1963 • 71 citations

Cell culture studies in CML

1987 • 65 citations

Human granulocytes generated in continuous bone marrow culture are physiologically normal

1981 • 64 citations

Discordant maturation as the primary biological defect in chronic myelogenous leukemia.

1988 • 63 citations

Chronic myelocytic leukemia (CML): failure to detect residual normal committed stem cells in vitro

1979 • 59 citations

The Biology of Normal and Neoplastic Stem Cells in CML

1993 • 59 citations

KARYOTYPIC CONVERSION IN Ph1-POSITIVE CHRONIC MYELOID LEUKÆMIA WITH COMBINATION CHEMOTHERAPY

1979 • 59 citations

Cytogenetic studies of early myeloid progenitor compartments in Ph¹‐positive chronic myeloid leukaemia (CML) I. PERSISTENCE OF Ph¹‐NEGATIVE COMMITTED PROGENITORS THAT ARE SUPPRESSED FROM DIFFERENTIATING IN VIVO

1984 • 58 citations

Quantitation and characterization of human megakaryocyte colony‐forming cells using a standardized serum‐free agarose assay

1997 • 58 citations

BCR-ABL expression in different subpopulations of functionally characterized Ph+ CD34+ cells from patients with chronic myeloid leukemia

1996 • 57 citations

Phenotypic heterogeneity of primitive leukemic hematopoietic cells in patients with chronic myeloid leukemia

1992 • 56 citations

Benign marrow progenitors are enriched in the CD34+/HLA-DRlo population but not in the CD34+/CD38lo population in chronic myeloid leukemia: an analysis using interphase fluorescence in situ hybridization

1995 • 54 citations

BCR – ABL accelerates C2-ceramide-induced apoptosis

1998 • 53 citations

Tumor necrosis factor mediates autocrine growth inhibition in a chronic leukemia.

1989 • 49 citations

The BCR-ABL oncogene requires both kinase activity and src-homology 2 domain to induce cytokine secretion

1996 • 47 citations

Abnormal erythropoiesis in the myeloproliferative disorders: an analysis of underlying cellular and humoral mechanisms.

1980 • 45 citations

Diverse effects of anti‐CD44 antibodies on the stromal cell‐mediated support of normal but not leukaemic (CML) haemopoiesis in vitro

1997 • 45 citations

Extremely Long Duration of Chronic Myeloid Leukaemia with Ph¹ Negative and Ph¹ Positive Bone Marrow Cells

1976 • 41 citations

Granulocyte-macrophage colony-stimulating factor modulation of the inhibitory effect of transforming growth factor-beta on normal and leukemic human hematopoietic progenitor cells.

1992 • 39 citations

Lack of evidence for abnormal autocrine or paracrine mechanisms underlying the uncontrolled proliferation of primitive chronic myeloid leukemia progenitor cells.

1991 • 36 citations

The BCR-ABL oncogene requires both kinase activity and src-homology 2 domain to induce cytokine secretion

1996 • 35 citations

Support of human cord blood progenitor cells on human stromal cell lines transformed by SV40 large T antigen under the influence of an inducible (metallothionein) promoter

1992 • 34 citations

Twenty‐five year survival of chronic granulocytic leukaemia with spontaneous karyotype conversion

1984 • 33 citations

Identification of properties that can distinguish primitive populations of stromal-cell-responsive lympho-myeloid cells from cells that are stromal-cell-responsive but lymphoid-restricted and cells that have lympho-myeloid potential but are also capable of competitively repopulating myeloablated recipients

1996 • 30 citations

Severe Combined Immunodeficiency Mice Engrafted With Human T Cells, B Cells, and Myeloid Cells After Transplantation With Human Fetal Bone Marrow or Liver Cells and Implanted With Human Fetal Thymus: A Model for Studying Human Gene Therapy

1997 • 27 citations

Identification of properties that can distinguish primitive populations of stromal-cell-responsive lympho-myeloid cells from cells that are stromal-cell-responsive but lymphoid-restricted and cells that have lympho-myeloid potential but are also capable of competitively repopulating myeloablated recipients

1996 • 25 citations

Support of human cord blood progenitor cells on human stromal cell lines transformed by SV40 large T antigen under the influence of an inducible (metallothionein) promoter

1992 • 25 citations

Biological strategies for the selective manipulation of normal and leukemic stem cells

1993 • 20 citations

Multiple granulocytic sarcoma after bmt for aml treated with donor leukocyte infusion plus il-2

1996 • 4 citations