Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1 alpha, an inhibitor of primitive normal hematopoietic cells.

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

1982 • 1,385 citations

Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor

1993 • 771 citations

Marrow Transplantation for the Treatment of Chronic Myelogenous Leukemia

1986 • 566 citations

Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

1990 • 535 citations

bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.

1990 • 371 citations

Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.

1993 • 349 citations

Long-Term Marrow Culture Reveals Chromosomally Normal Hematopoietic Progenitor Cells in Patients with Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia

1983 • 335 citations

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer

1991 • 292 citations

Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. Interacting effects involving suppression, synergistic suppression, and blocking of suppression.

1993 • 273 citations

Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells

1990 • 236 citations

Transforming growth factor beta selectively inhibits normal and leukemic human bone marrow cell growth in vitro

1988 • 229 citations

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. I. Stimulatory role of a variety of mesenchymal cell activators and inhibitory role of TGF-beta

1990 • 227 citations

Unregulated proliferation of primitive chronic myeloid leukemia progenitors in the presence of normal marrow adherent cells.

1986 • 191 citations

Demonstration of stem cell inhibition and myeloprotective effects of SCI/rhMIP1 alpha in vivo

1992 • 178 citations

Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro

1992 • 170 citations

Transforming growth factor beta directly regulates primitive murine hematopoietic cell proliferation

1990 • 164 citations

Growth characteristics of leukemic and normal hematopoietic cells in Ph' + chronic myelogenous leukemia and effects of intensive treatment

1982 • 159 citations

Regulated proliferation of primitive hematopoietic progenitor cells in long-term human marrow cultures

1985 • 144 citations

Macrophage-inflammatory protein protects multipotent hematopoietic cells from the cytotoxic effects of hydroxyurea in vivo

1992 • 114 citations

Intensive combination chemotherapy (ROAP 10) and splenectomy in the management of chronic myelogenous leukemia.

1985 • 111 citations

Inhibition of early murine hemopoietic progenitor cell proliferation after in vivo locoregional administration of transforming growth factor-beta 1.

1989 • 107 citations

The Use of Cell Markers in The Study of Human Hematopoietic Neoplasia

1987 • 103 citations

Macrophage inflammatory protein (MIP)-1 beta abrogates the capacity of MIP-1 alpha to suppress myeloid progenitor cell growth.

1991 • 71 citations

Growth Inhibitory Effects of Transforming Growth Factor-β1 in vivo

1991 • 71 citations

Cytogenetic studies of early myeloid progenitor compartments in Ph1- positive chronic myeloid leukemia. II. Long-term culture reveals the persistence of Ph1-negative progenitors in treated as well as newly diagnosed patients

1984 • 67 citations

Phenotypic heterogeneity of primitive leukemic hematopoietic cells in patients with chronic myeloid leukemia

1992 • 56 citations

Differential and synergistic effects of human granulocyte-macrophage colony-stimulating factor and human granulocyte colony-stimulating factor on hematopoiesis in human long-term marrow cultures

1991 • 50 citations

Granulocyte-macrophage colony-stimulating factor modulation of the inhibitory effect of transforming growth factor-beta on normal and leukemic human hematopoietic progenitor cells.

1992 • 39 citations

Lack of evidence for abnormal autocrine or paracrine mechanisms underlying the uncontrolled proliferation of primitive chronic myeloid leukemia progenitor cells.

1991 • 36 citations

: A potent stem cell inhibitor with potential roles in development

1992 • 35 citations