Morphogens, Compartments, and Pattern: Lessons from Drosophila?

The chemical basis of morphogenesis

1952 • 11,233 citations

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

A gene complex controlling segmentation in Drosophila

1978 • 3,668 citations

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

DEVELOPMENT IN DROSOPHILA MELANOGASTER

1927 • 2,909 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Hox genes in vertebrate development

1994 • 2,057 citations

The origin of pattern and polarity in the Drosophila embryo

1992 • 1,367 citations

The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner

1988 • 1,022 citations

A gradient of bicoid protein in Drosophila embryos

1988 • 1,015 citations

Direct and Long-Range Action of a DPP Morphogen Gradient

1996 • 896 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

Organizing activity of wingless protein in Drosophila

1993 • 852 citations

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

1994 • 842 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

Developmental Compartmentalisation of the Wing Disk of Drosophila

1973 • 770 citations

A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family

1987 • 756 citations

The gradient morphogen bicoid is a concentration-dependent transcriptional activator

1989 • 655 citations

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing

1996 • 629 citations

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1994 • 624 citations

Positional signalling and specification of digits in chick limb morphogenesis

1975 • 588 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

Genetic Control of Wing Disc Development in Drosophila

1975 • 584 citations

Genetic organization of Drosophila bithorax complex

1985 • 514 citations

Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate

1990 • 508 citations

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

1995 • 505 citations

Parasegments and compartments in the Drosophila embryo

1985 • 492 citations

Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing

1995 • 489 citations

Responses of embryonic xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm

1992 • 486 citations

The engrailed locus of drosophila: In situ localization of transcripts reveals compartment-specific expression

1985 • 456 citations

Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs

1993 • 454 citations

Distribution of the wingless gene product in drosophila embryos: A protein involved in cell-cell communication

1989 • 452 citations

Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.

1994 • 451 citations

Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen

1989 • 432 citations

Control of compartment development by the engrailed gene in Drosophila

1975 • 429 citations

Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein

1985 • 406 citations

The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation.

1992 • 400 citations

Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing

1995 • 392 citations

Imprinting a determined state into the chromatin of Drosophila

1990 • 391 citations

Organization of anterior pattern in the Drosophila embryo by the maternal gene bicoid

1986 • 386 citations

A gene product required for correct initiation of segmental determination in Drosophila

1981 • 361 citations

Interaction between dorsal and ventral cells in the imaginal disc directs wing development in Drosophila

1993 • 359 citations

The cellular basis of segmentation in the developing hindbrain

1990 • 358 citations

Transcriptional regulation of a pair-rule stripe in Drosophila.

1991 • 354 citations

Isolation of a homoeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts

1985 • 346 citations

Decapentaplegic: A gene complex affecting morphogenesis in Drosophila melanogaster

1982 • 345 citations

fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development

1994 • 341 citations

Activin signalling and response to a morphogen gradient

1994 • 328 citations

Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen

1993 • 322 citations

Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.

1996 • 316 citations

Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc

1996 • 303 citations

Roles of wingless in patterning the larval epidermis of Drosophila

1991 • 295 citations

Control of Drosophila body pattern by the hunchback morphogen gradient

1992 • 294 citations

HOX-4 genes and the morphogenesis of mammalian genitalia.

1991 • 292 citations

Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions

1993 • 292 citations

Cell determination boundaries as organizing regions for secondary embryonic fields

1983 • 267 citations

The making of a fly

1992 • 258 citations

A morphogenetic gradient of hunchback protein organizes the expression of the gap genes Krüppel and knirps in the early Drosophila embryo

1990 • 258 citations

POLYCOMBLIKE: A GENE THAT APPEARS TO BE REQUIRED FOR THE NORMAL EXPRESSION OF THE BITHORAX AND ANTENNAPEDIA GENE COMPLEXES OF DROSOPHILA MELANOGASTER

1982 • 258 citations

Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing drosophila wing

1995 • 257 citations

Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila

1992 • 248 citations

Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis

1995 • 246 citations

A gene complex acting downstream of dpp in Drosophila wing morphogenesis

1996 • 232 citations

Synergy between the hunchback and bicoid morphogens is required for anterior patterning in Drosophila

1994 • 232 citations

Differential mitotic rates and patterns of growth in compartments in the Drosophila wing

1981 • 222 citations

Drosophila hedgehog acts as a morphogen in cellular patterning

1994 • 215 citations

The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development.

1994 • 212 citations

Control of the Gene optomotor-blind in Drosophila Wing Development by decapentaplegic and wingless

1996 • 206 citations

Cell lineage relationships in the imaginal wing disc of Drosophila melanogaster

1970 • 203 citations

Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila.

1988 • 190 citations

Gradients in the Insect Segment: The Orientation of Hairs in the Milkweed Bug Oncopeltus Fasciatus

1966 • 178 citations

The role of apterous in the control of dorsoventral compartmentalization and PS integrin gene expression in the developing wing of Drosophila

1994 • 176 citations

Compartments and appendage development in Drosophila

1995 • 175 citations

The state of engrailed expression is not clonally transmitted during early Drosophila development

1992 • 173 citations

Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo

1993 • 172 citations

Wing formation in Drosophila melanogaster requires decapentaplegic gene function along the anterior-posterior compartment boundary

1990 • 170 citations

Analysis of the genetic hierarchy guiding wing vein development in Drosophila

1995 • 165 citations

Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice

1995 • 155 citations

The Cuticular Pattern in An Insect, Rhodnius Prolixus Stål

1959 • 152 citations

Direct and continuous assessment by cells of their position in a morphogen gradient

1995 • 150 citations

A Gradient of Positional Information in an Insect, Rhodnius

1972 • 148 citations

The function of engrailed and the specification of Drosophila wing pattern

1995 • 146 citations

DEVELOPMENTAL GENETICS OF THE VENATION PATTERN OF DROSOPHILA

1992 • 144 citations

Drawing a stripe in Drosophila imaginal disks: negative regulation of decapentaplegic and patched expression by engrailed.

1995 • 134 citations

Further studies of the engrailed phenotype in Drosophila.

1982 • 130 citations

Splitting the bithorax complex of Drosophila

1984 • 127 citations

The Drosophila morphogenetic protein Bicoid binds DNA cooperatively

1996 • 124 citations

Early role of the esc+ gene product in the determination of segments in Drosophila

1982 • 115 citations

Distinguishable functions for engrailed and Invected in anterior–posterior patterning in the Drosopila wing

1995 • 111 citations

Compartments in Animal Development

1979 • 110 citations

Function of the Polycomb protein is conserved in mice and flies

1995 • 100 citations

Transcriptional silencing of homeotic genes in drosophila

1995 • 100 citations

Specification of a single cell type by a Drosophila homeotic gene

1994 • 96 citations

A clonal analysis of segment development inOncopeltus(Hemiptera)

1973 • 92 citations

Three distinct roles for the engrailed gene in Drosophila wing development

1994 • 87 citations

Mechanism by which Cells estimate their Location within the Body

1966 • 83 citations

Mechanisms of compartment formation: Evidence that non-proliferating cells do not play a critical role in defining the D/V lineage restriction in the developing wing of Drosophila

1993 • 80 citations

A role for wingless in the segmental gradient of Drosophila?

1993 • 55 citations

Interactions between rhombomeres modulate Krox-20 and follistatin expression in the chick embryo hindbrain

1996 • 53 citations

Tripartite signaling of pattern: interactions between Hedgehogs, BMPs and Wnts in the control of vertebrate development

1996 • 51 citations

Further Studies on Gradient-Dependent Diversification in the Pupal Cuticle of Galleria Mellonella

1968 • 44 citations

Extent and properties of the regeneration field in the larval legs of cockroaches (Leucophaea maderae) III. Origin of the tissues and determination of symmetry properties in the regenerates.

1974 • 19 citations

Dorsal wing, a locus that affects dorsoventral wing patterning in Drosophila

1995 • 14 citations