Dorsal-Ventral Gene Expression in the Drosophila Embryo Reflects the Dynamics and Precision of the Dorsal Nuclear Gradient

An optimized transgenesis system for Drosophila using germ-line-specific φC31 integrases

2007 • 1,874 citations

Simple and highly efficient BAC recombineering using galK selection

2005 • 1,227 citations

Construction of Transgenic Drosophila by Using the Site-Specific Integrase From Phage C31

2004 • 1,025 citations

Global Analysis of mRNA Localization Reveals a Prominent Role in Organizing Cellular Architecture and Function

2007 • 958 citations

P[acman]: A BAC Transgenic Platform for Targeted Insertion of Large DNA Fragments in D. melanogaster

2006 • 800 citations

Probing the Limits to Positional Information

2007 • 698 citations

Dynamic control of positional information in the early Drosophila embryo

2004 • 577 citations

Stability and Nuclear Dynamics of the Bicoid Morphogen Gradient

2007 • 510 citations

The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development

1991 • 501 citations

Deep and fast live imaging with two-photon scanned light-sheet microscopy

2011 • 467 citations

Progression of the cell cycle through mitosis leads to abortion of nascent transcripts

1991 • 379 citations

Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen

1993 • 322 citations

Spatial and temporal patterns of E74 transcription during Drosophila development

1990 • 254 citations

Synchronous and Stochastic Patterns of Gene Activation in the Drosophila Embryo

2009 • 252 citations

Genomic Regulatory Networks and Animal Development

2005 • 225 citations

Transcriptional regulatory cascades in development: Initial rates, not steady state, determine network kinetics

2003 • 217 citations

Pre-Steady-State Decoding of the Bicoid Morphogen Gradient

2007 • 200 citations

Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog

2010 • 197 citations

The Formation of the Bicoid Morphogen Gradient Requires Protein Movement from Anteriorly Localized mRNA

2011 • 178 citations

Computational Models for Neurogenic Gene Expression in the Drosophila Embryo

2006 • 170 citations

Direct and continuous assessment by cells of their position in a morphogen gradient

1995 • 150 citations

Loss of gene function through rapid mitotic cycles in the Drosophila embryo

1992 • 150 citations

A microfluidic array for large-scale ordering and orientation of embryos

2010 • 142 citations

Transcriptional regulation of the Drosophila gene zen by competing Smad and Brinker inputs

2001 • 128 citations

Biphasic activation of the BMP pathway patterns the Drosophila embryonic dorsal region

2001 • 126 citations

Fundamental Limits to Position Determination by Concentration Gradients

2007 • 123 citations

The Bicoid Morphogen System

2010 • 120 citations

Dynamics of the Dorsal morphogen gradient

2009 • 113 citations

Graded Dorsal and Differential Gene Regulation in the Drosophila Embryo

2009 • 113 citations

On the dynamic nature of positional information

2006 • 100 citations

Anterior-posterior positional information in the absence of a strong Bicoid gradient

2009 • 97 citations

Complex interactions between cis-regulatory modules in native conformation are critical for Drosophila snail expression

2011 • 87 citations

Nucleocytoplasmic shuttling mediates the dynamic maintenance of nuclear Dorsal levels duringDrosophilaembryogenesis

2007 • 84 citations

A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning

2010 • 83 citations

Quantitative imaging of the Dorsal nuclear gradient reveals limitations to threshold-dependent patterning in Drosophila

2009 • 83 citations

Dynamic Interpretation of Hedgehog Signaling in the Drosophila Wing Disc

2009 • 81 citations

Design flexibility in cis-regulatory control of gene expression: Synthetic and comparative evidence

2008 • 77 citations

Temporal dynamics of patterning by morphogen gradients

2009 • 73 citations

A Precise Bicoid Gradient Is Nonessential during Cycles 11–13 for Precise Patterning in the Drosophila Blastoderm

2008 • 44 citations

Gene length may contribute to graded transcriptional responses in the Drosophila embryo

2011 • 18 citations

Identification of an upstream regulatory element reveals a novel requirement for Ind activity in maintaining ind expression

2006 • 12 citations

Morphogen Gradients: Limits to Signaling or Limits to Measurement?

2010 • 11 citations