Human melanoma metastasis is inhibited following ex vivo treatment with an antisense oligonucleotide to protein kinase C-α

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

Cancer metastasis

1982 • 567 citations

A line of non‐tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth

1987 • 475 citations

Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms.

1991 • 468 citations

Activation of protein kinase C precedes alpha 5 beta 1 integrin-mediated cell spreading on fibronectin.

1993 • 358 citations

Inhibition of protein kinase C-alpha expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters.

1994 • 289 citations

Regulation of protein kinase C and role in cancer biology

1994 • 258 citations

Does antisense exist?

1995 • 257 citations

Inhibition of protein kinase C-alpha expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides.

1994 • 242 citations

Protein kinase C and its substrates

1996 • 236 citations

Technical considerations for studying cancer metastasis in vivo.

1997 • 193 citations

Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell line

1991 • 191 citations

Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression.

1996 • 178 citations

Therapeutic Applications Of Oligonucleotides

1992 • 158 citations

Immune stimulation--a class effect of phosphorothioate oligodeoxynucleotides in rodents.

1997 • 124 citations

Effect of protein kinase inhibitor H‐7 on the contractility, integrity, and membrane anchorage of the microfilament system

1994 • 121 citations

Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis.

1988 • 107 citations

Inhibition of Invasion of Invasive Human Bladder Carcinoma Cells by Protein Kinase C Inhibitor Staurosporine

1990 • 94 citations

Oligonucleotide‐mediated modulation of mammalian gene expression ¹

1995 • 80 citations

Implications of tumor progression on clinical oncology

1985 • 74 citations

Stimulation of murine lymphocyte proliferation by a phosphorothioate oligonucleotide with antisense activity for herpes simplex virus

1994 • 64 citations

Ability of Oligonucleotides with Certain Palindromes to Induce Interferon Production and Augment Natural Killer Cell Activity Is Associated with Their Base Length

1994 • 64 citations

Effects of 12-O-tetradecanoylphorbol-13-acetate on adhesiveness and lung-colonizing ability of Lewis lung carcinoma cells.

1986 • 63 citations

Possible involvement of Ca2+ mobilization and protein kinase C activation in the induction of spontaneous metastasis by mouse mammary adenocarcinoma cells.

1989 • 60 citations

The differential expression of protein kinase C genes in normal human neonatal melanocytes and metastatic melanomas

1991 • 52 citations

Protein‐kinase‐C inhibitor calphostin C reduces B16 amelanotic melanoma cell adhesion to endothelium and lung colonization

1992 • 46 citations

Inhibition of experimental metastasis and cell adhesion of B16F1 melanoma cells by inhibitors of protein kinase C.

1992 • 44 citations

Role of Protein Kinase C in Attachment, Spreading, and Migration of Human Endothelial Cells

1996 • 43 citations

Modulation of Human Melanoma Cell Metastasis and Adhesion May Involve Integrin Phosphorylation Mediated Through Protein Kinase C

1994 • 37 citations

Therapeutic Applications of Oligonucleotides

1992 • 37 citations

Role of Protein Kinase C in Intracellular Signaling

1994 • 33 citations

Activation of protein kinase C-alpha isoform in murine melanoma cells with high metastatic potential.

1997 • 26 citations

Effect of protein kinase C inhibitors on invasiveness of human melanoma clones expressing different levels of protein kinase C isoenzymes

1994 • 24 citations

Antisense Oligonucleotides Targeting Human Protein Kinase C-α Inhibit Phorbol Ester-Induced Reduction of Bradykinin-Evoked Calcium Mobilization in A549 Cells

1997 • 22 citations

Phorbol esters and growth regulation in metastatic melanoma cells

1991 • 8 citations