Therapeutic Applications of Oligonucleotides

Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide

1991 • 3,211 citations

Predicting DNA duplex stability from the base sequence.

1986 • 1,800 citations

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide.

1978 • 1,668 citations

Antisense oligonucleotides: a new therapeutic principle

1990 • 1,616 citations

Improved free-energy parameters for predictions of RNA duplex stability.

1986 • 1,472 citations

SPLICING OF MESSENGER RNA PRECURSORS

1986 • 1,233 citations

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

1987 • 696 citations

PRE-mRNA SPLICING

1986 • 673 citations

Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons

1990 • 638 citations

Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.

1987 • 530 citations

A c- myb Antisense Oligodeoxynucleotide Inhibits Normal Human Hematopoiesis in Vitro

1988 • 439 citations

Inhibition of Cellular Proliferation by Antisense Oligodeoxynucleotides to PCNA Cyclin

1988 • 425 citations

Anti-Cancer Drug Design

1985 • 418 citations

Inhibition of replication and expression of human T-cell lymphotropic virus type III in cultured cells by exogenous synthetic oligonucleotides complementary to viral RNA.

1986 • 403 citations

Extension of the Life-Span of Human Endothelial Cells by an Interleukin-1αAntisense Oligomer

1990 • 399 citations

Antiviral effect of an oligo(nucleoside methylphosphonate) complementary to the splice junction of herpes simplex virus type 1 immediate early pre-mRNAs 4 and 5.

1986 • 295 citations

Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells

1989 • 293 citations

Oligodeoxynucleoside phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus.

1988 • 289 citations

Automated solid-phase synthesis, separation, and stereochemistry of phosphorothioate analogs of oligodeoxyribonucleotides

1984 • 272 citations

Polyadenylation of mRNA precursors

1988 • 210 citations

Comparative inhibition of chloramphenicol acetyltransferase gene expression by antisense oligonucleotide analogues having alkyl phosphotriester, methylphosphonate and phosphorothioate linkages

1987 • 173 citations

Suppression of basic fibroblast growth factor expression by antisense oligodeoxynucleotides inhibits the growth of transformed human astrocytes.

1991 • 162 citations

BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense.

1990 • 157 citations

Tumour-specific inhibition of lymphoma growth by an antisense oligodeoxynucleotide

1990 • 151 citations

Prothymosin alpha antisense oligomers inhibit myeloma cell division.

1991 • 145 citations

Rate of degradation of [α]- and [β]-oligodeoxynucleotides inXenopusoocytes. Implications for anti-messenger strategies

1987 • 143 citations

Synthesis, hybridization properties and antiviral activity of lipid-oligodeoxynucleotide conjugates

1990 • 140 citations

Site specificity of the inhibitory effects of oligo(nucleoside methylphosphonate)s complementary to the acceptor splice junction of herpes simplex virus type 1 immediate early mRNA 4.

1989 • 136 citations

Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element

1991 • 133 citations

Selective inhibition of the cytopathic effect of type A influenza viruses by oligodeoxynucleotides covalently linked to an intercalating agent

1987 • 131 citations

Conformation of an RNA pseudoknot

1990 • 129 citations

Control of ribonucleic acid function by oligonucleoside methylphosphonates

1985 • 115 citations

Inhibition of rabbit globin mRNA translation by sequence-specific oligodeoxyribonucleotides

1985 • 115 citations

Cloning of a phospholipase A2-activating protein.

1991 • 107 citations

RNA 3' END FORMATION IN THE CONTROL OF GENE EXPRESSION

1987 • 98 citations

Highly specific inhibition of IGF-I-stimulated differentiation by an antisense oligodeoxyribonucleotide to myogenin mRNA. No effects on other actions of IGF-T.

1990 • 92 citations

An antisense oligodeoxynucleotide targeted against the type II beta regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects.

1990 • 85 citations

Effect of Phosphorothioate Homo-oligodeoxy nucleotides on Herpes Simplex Virus Type 2-induced DNA Polymerase

1989 • 85 citations

Antisense Oligodeoxyribonucleotides Inhibit the Expression of the Gene for Hepatitis B Virus Surface Antigen

1990 • 81 citations

Inhibition of lymphocyte mediated cytotoxicity by perforin antisense oligonucleotides.

1990 • 73 citations

Specific inhibition of cell-surface T-cell receptor expression by antisense oligodeoxynucleotides and its effect on the production of an antigen-specific regulatory T-cell factor.

1989 • 45 citations

Anti-c-myc DNA increases differentiation and decreases colony formation by HL-60 cells

1989 • 44 citations

Specific inhibition of lymphokine biosynthesis and autocrine growth using antisense oligonucleotides in Th1 and Th2 helper T cell clones.

1988 • 42 citations

Concerning Antisense Inhibition of the Multiple Drug Resistance Gene

1990 • 37 citations

Reduction of herpes simplex virus infection using phosphorothioate oligonucleotides complementary to viral mRNA

1991 • 4 citations