Phorbol esters and growth regulation in metastatic melanoma cells

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester.

1979 • 1,019 citations

Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin.

1982 • 552 citations

Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes.

1988 • 489 citations

[6] The growth of cells in serum-free hormone-supplemented media

1979 • 330 citations

Transforming ras genes from human melanoma: a manifestation of tumour heterogeneity?

1984 • 322 citations

Mapping the Gene for Hereditary Cutaneous Malignant Melanoma–Dysplastic Nevus to Chromosome Lp

1989 • 320 citations

bFGF is the putative natural growth factor for human melanocytes

1987 • 259 citations

Phenotypic changes of human neuroblastoma cells in culture induced by 12‐O‐tetradecanoyl‐phorbol‐13‐acetate

1981 • 255 citations

bFGF as an autocrine growth factor for human melanomas.

1988 • 237 citations

Biology of tumor progression in human melanocytes.

1987 • 236 citations

Differential Down-regulation of Protein Kinase C Isozymes

1989 • 219 citations

Dissociation of protein kinase C activation from phorbol ester-induced maturation of HL-60 leukemia cells.

1985 • 218 citations

Analysis of ras oncogenes in malignant melanoma and precursor lesions: correlation of point mutations with differentiation phenotype.

1989 • 212 citations

Growth of Cells in Hormonally Defined Media

1983 • 187 citations

Selective elimination of fibroblasts from cultures of normal human melanocytes

1984 • 183 citations

Control of thymidine kinase mRNA during the cell cycle.

1987 • 176 citations

Binding of phorbol esters to high‐affinity sites on murine fibroblastic cells elicits a mitogenic response

1982 • 167 citations

Human Melanocytes Cultured from Nevi and Melanomas

1986 • 155 citations

Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment.

1989 • 146 citations

A novel transforming gene in a human malignant melanoma cell line

1984 • 135 citations

Phorbol esters from croton oil chemical nature and biological activities

1967 • 135 citations

Serum‐free culture of normal human melanocytes: Growth kinetics and growth factor requirements

1989 • 132 citations

Identification of a recurring translocation site involving chromosome 6 in human malignant melanoma.

1989 • 106 citations

Extracellular signals, transcriptional responses and cellular specificity

1989 • 98 citations

Cells that overproduce protein kinase C are more susceptible to transformation by an activated H-ras oncogene.

1989 • 93 citations

Early effects of 12-O-tetradecanoyl-phorbol-13-acetate on the incorporation of tritiated precursor into DNA and the thickness of the interfollicular epidermis, and their relation to tumor promotion in mouse skin.

1972 • 82 citations

Evidence against Ha-ras-1 involvement in sporadic and familial melanoma

1987 • 78 citations

Growth of Cells in Hormonally Defined Media

1983 • 77 citations

Tyrosine kinase-activating growth factors potentiate thrombin- and AIF4- -induced phosphoinositide breakdown in hamster fibroblasts. Evidence for positive cross-talk between the two mitogenic signaling pathways.

1988 • 73 citations

Disturbances in growth control and gene expression in a C3H/10T1/2 cell line that stably overproduces protein kinase C.

1989 • 64 citations

Biological properties of human melanoma cells in culture

1979 • 53 citations

Inhibition of phorbol ester-caused induction of ornithine decarboxylase and tumor promotion in mouse skin by staurosporine, a potent inhibitor of protein kinase C

1988 • 48 citations

Responses of Cultured Melanocytes to Defined Growth Factors

1988 • 39 citations

[Morphology of the epidermal melanin unit].

1969 • 33 citations

Zur Morphologic der epidermalen Melanineinheit

1969 • 31 citations

Characterization of the growth inhibition induced by tumor-promoting phorbol esters and of their receptor binding in A549 human lung carcinoma cells.

1985 • 28 citations

Studies on bioactive compounds. 13. Synthesis and lack of growth-inhibitory properties of cyclohexane-1,2,4-triol 1,2-diesters, which resemble ring C of the phorbol ester molecule

1989 • 22 citations

Polyoma middle T abrogates TPA requirement of murine melanocytes and induces malignant melanoma.

1988 • 21 citations

Relationship of cellular oncogene expression to inhibition of growth and induction of differentiation of Daudi cells by interferons or TPA

1988 • 15 citations

The Role of Oncogenes in the Pathogenesis of Malignant Melanoma

1987 • 10 citations

Basic and acidic fibroblast growth factors modulate the epidermal growth factor receptor by a protein kinase C-independent pathway

1989 • 8 citations

Basic and Clinical Aspects of Malignant Melanoma

1990 • 1 citations