ADAMs, cell migration and cancer

Integrins

2002 • 8,127 citations

Untangling the ErbB signalling network

2001 • 6,623 citations

Cell Migration: Integrating Signals from Front to Back

2003 • 4,755 citations

Handbook of Proteolytic Enzymes

2004 • 2,698 citations

Integrin signalling during tumour progression

2004 • 1,430 citations

Mechanisms and functions of eph and ephrin signalling

2002 • 1,139 citations

ADAMs: key components in EGFR signalling and development

2005 • 1,056 citations

The ADAMs family of metalloproteases: multidomain proteins with multiple functions

2003 • 1,052 citations

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

2004 • 965 citations

γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase

2001 • 848 citations

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

2002 • 657 citations

N<scp>OTCH AND</scp>P<scp>RESENILIN</scp>: Regulated Intramembrane Proteolysis Links Development and Degeneration

2003 • 640 citations

Regulated Cleavage of a Contact-Mediated Axon Repellent

2000 • 522 citations

Fibulins: a versatile family of extracellular matrix proteins

2003 • 469 citations

Shedding light on ADAM metalloproteinases

2005 • 449 citations

Adam Meets Eph: An ADAM Substrate Recognition Module Acts as a Molecular Switch for Ephrin Cleavage In trans

2005 • 434 citations

EGFR signal transactivation in cancer cells

2003 • 407 citations

ADAMs: modulators of cell–cell and cell–matrix interactions

2003 • 406 citations

L1, a novel target of β-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers

2005 • 349 citations

Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling

2005 • 348 citations

The role of ephrins and Eph receptors in cancer

2004 • 326 citations

The Integrin α9β1 Binds to a Novel Recognition Sequence (SVVYGLR) in the Thrombin-cleaved Amino-terminal Fragment of Osteopontin

1999 • 299 citations

Cell–matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation

2004 • 288 citations

Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function

2002 • 282 citations

L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas

2003 • 271 citations

TACE is required for the activation of the EGFR by TGF-α in tumors

2003 • 270 citations

Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor

1999 • 262 citations

ADAM 12 Cleaves Extracellular Matrix Proteins and Correlates with Cancer Status and Stage

2004 • 237 citations

Back signaling by the Nrg-1 intracellular domain

2003 • 237 citations

Protein Ectodomain Shedding

2002 • 234 citations

ERK-mediated phosphorylation of Thr735 in TNFα-converting enzyme and its potential role in TACE protein trafficking

2005 • 232 citations

Snake venoms and hemostasis

2005 • 218 citations

Specific Interaction of the Recombinant Disintegrin-like Domain of MDC-15 (Metargidin, ADAM-15) with Integrin αvβ3

1998 • 214 citations

RGD-independent Binding of Integrin α9β1 to the ADAM-12 and -15 Disintegrin Domains Mediates Cell-Cell Interaction

2000 • 211 citations

Cysteine-Rich Domain of Human ADAM 12 (Meltrin α) Supports Tumor Cell Adhesion

1999 • 209 citations

ADAM12 in human liver cancers: TGF-β-regulated expression in stellate cells is associated with matrix remodeling

2003 • 195 citations

Interaction of metargidin (ADAM-15) with αvβ3 and α5β1 integrins on different haemopoietic cells

1999 • 193 citations

Meltrin γ (ADAM-9) mediates cellular adhesion through α6β1 integrin, leading to a marked induction of fibroblast cell motility

2000 • 190 citations

Role of tethering factors in secretory membrane traffic

2005 • 188 citations

A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions

2005 • 184 citations

Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans

1999 • 182 citations

Distinct ADAM Metalloproteinases Regulate G Protein-coupled Receptor-induced Cell Proliferation and Survival

2004 • 167 citations

Functional Classification of ADAMs Based on a Conserved Motif for Binding to Integrin α9β1

2002 • 159 citations

Clinical Significance of Heparin-Binding Epidermal Growth Factor–Like Growth Factor and A Disintegrin and Metalloprotease 17 Expression in Human Ovarian Cancer

2005 • 158 citations

ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk

2004 • 158 citations

The Forkhead Box M1 Transcription Factor Is Essential for Embryonic Development of Pulmonary Vasculature

2005 • 156 citations

Increased expression of ADAM family members in human breast cancer and breast cancer cell lines

2004 • 156 citations

The gon-1 Gene Is Required for Gonadal Morphogenesis in Caenorhabditis elegans

1999 • 155 citations

The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer

2005 • 155 citations

Evaluation of the contributions of ADAMs 9, 12, 15, 17, and 19 to heart development and ectodomain shedding of neuregulins β1 and β2

2005 • 153 citations

ADAM12 Is Selectively Overexpressed in Human Glioblastomas and Is Associated with Glioblastoma Cell Proliferation and Shedding of Heparin-Binding Epidermal Growth Factor

2004 • 150 citations

Oxidative and Osmotic Stress Signaling in Tumor Cells Is Mediated by ADAM Proteases and Heparin-Binding Epidermal Growth Factor

2004 • 149 citations

ADAM8 as a Novel Serological and Histochemical Marker for Lung Cancer

2004 • 145 citations

Identification of novel proteins associated with hepatocellular carcinomas using protein microarrays

2003 • 141 citations

ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating β1 integrin function

2003 • 140 citations

A Role for ADAM12 in Breast Tumor Progression and Stromal Cell Apoptosis

2005 • 138 citations

Expression of ADAM‐9 mRNA and protein in human breast cancer

2003 • 138 citations

Up‐regulated expression of ADAM17 in human colon carcinoma: co‐expression with EGFR in neoplastic and endothelial cells

2005 • 135 citations

Overexpression of ADAM9 in Non-Small Cell Lung Cancer Correlates with Brain Metastasis

2004 • 135 citations

Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines

2004 • 129 citations

Sequence-Specific Interaction between the Disintegrin Domain of Mouse ADAM 3 and Murine Eggs: Role of β1 Integrin-associated Proteins CD9, CD81, and CD98

2001 • 122 citations

ADAM 23/MDC3, a Human Disintegrin That Promotes Cell Adhesion via Interaction with the αvβ3 Integrin through an RGD-independent Mechanism

2000 • 115 citations

Critical Function for ADAM9 in Mouse Prostate Cancer

2005 • 113 citations

Gene expression profiles of microdissected pancreatic ductal adenocarcinoma

2003 • 111 citations

A Metalloprotease Disintegrin That Controls Cell Migration in Caenorhabditis elegans

2000 • 104 citations

Sequence-specific Interaction between the Disintegrin Domain of Mouse ADAM 2 (Fertilin β) and Murine Eggs

2000 • 100 citations

The mechanism of cleavage of EGFR ligands induced by inflammatory cytokines in gastric cancer cells

2004 • 99 citations

Focus on breast cancer

2002 • 97 citations

Shedding of membrane proteins by ADAM family proteases

2002 • 96 citations

Fibulin-1 Acts as a Cofactor for the Matrix Metalloprotease ADAMTS-1

2005 • 96 citations

Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas

2003 • 95 citations

Selective Modulation of Integrin-mediated Cell Migration by Distinct ADAM Family Members

2005 • 93 citations

ADAMs(A Disintegrin and Metalloproteinase) Messenger RNA Expression inHelicobacter pylori–Infected, Normal, and Neoplastic Gastric Mucosa

2002 • 90 citations

How ADAM-9 and ADAM-11 Differentially From Estrogen Receptor Predict Response to Tamoxifen Treatment in Patients with Recurrent Breast Cancer: a Retrospective Study

2005 • 87 citations

Immunoprofiles of 11 Biomarkers Using Tissue Microarrays Identify Prognostic Subgroups in Colorectal Cancer

2005 • 86 citations

MDC-9 (ADAM-9/Meltrin γ) Functions as an Adhesion Molecule by Binding the αvβ5 Integrin

2001 • 84 citations

ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis

2005 • 84 citations

Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma

2005 • 84 citations

ADAM Binding Protein Eve-1 Is Required for Ectodomain Shedding of Epidermal Growth Factor Receptor Ligands

2004 • 83 citations

Mutations Affecting Symmetrical Migration of Distal Tip Cells in Caenorhabditis elegans

1999 • 81 citations

Integrin α5β1 and ADAM-17 Interact in Vitro and Co-localize in Migrating HeLa Cells

2004 • 78 citations

The Lymphocyte Metalloprotease MDC-L (ADAM 28) Is a Ligand for the Integrin α4β1

2002 • 74 citations

ADAM17 mRNA expression and pathological features of hepatocellular carcinoma

2004 • 72 citations

Epigenetic silencing of the adhesion molecule ADAM23 is highly frequent in breast tumors

2003 • 71 citations

Regulation of ADAM12 Cell-surface Expression by Protein Kinase C ϵ

2004 • 66 citations

A Fibulin-1 Homolog Interacts with an ADAM Protease that Controls Cell Migration in C. elegans

2004 • 64 citations

Shedding of Collagen XVII Ectodomain Depends on Plasma Membrane Microenvironment

2005 • 63 citations

ADAM disintegrin-like domain recognition by the lymphocyte integrins α4β1 and α4β7

2005 • 63 citations

An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans

2003 • 63 citations

The ErbB-4 s80 intracellular domain is a constitutively active tyrosine kinase

2005 • 60 citations

The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease inC. elegans

2005 • 59 citations

GON-1 and Fibulin Have Antagonistic Roles in Control of Organ Shape

2004 • 59 citations

Adam‐9 expression and regulation in human skin melanoma and melanoma cell lines

2005 • 56 citations

Increased mRNA expression of ADAMs in renal cell carcinoma and their association with clinical outcome

2004 • 54 citations

Role of multiple β1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3

2003 • 52 citations

THE MEMBRANE PROTEASES ADAMS AND HEPSIN ARE DIFFERENTIALLY EXPRESSED IN RENAL CELL CARCINOMA. ARE THEY POTENTIAL TUMOR MARKERS?

2004 • 50 citations

Expression of ADAM15 in lung carcinomas

2005 • 49 citations

Up-regulation of MDC15 (metargidin) messenger RNA in human osteoarthritic cartilage

1999 • 44 citations

Defects in Secretory Pathway Trafficking During Sperm Development in Adam2 Knockout Mice1

2005 • 38 citations

Hierarchy of ADAM12 binding to integrins in tumor cells

2005 • 33 citations

Shedding of plasma membrane proteins

2003 • 33 citations

Inactivating mutations block the tumor necrosis factor-α-converting enzyme in the early secretory pathway

2004 • 25 citations

ADAM proteases, ErbB pathways and cancer

2005 • 24 citations

Targeting Ligand Cleavage to Inhibit the ErbB Pathway in Cancer

2005 • 5 citations