ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression

Stromal fibroblasts in cancer initiation and progression

2004 • 2,230 citations

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

1990 • 1,550 citations

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.

1992 • 1,496 citations

ADAMs: key components in EGFR signalling and development

2005 • 1,056 citations

Induction of Mammary Tumors by Expression of Polyomavirus Middle T Oncogene: A Transgenic Mouse Model for Metastatic Disease

1992 • 812 citations

Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

2002 • 727 citations

Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion

2003 • 631 citations

Prostate Pathology of Genetically Engineered Mice: Definitions and Classification. The Consensus Report from the Bar Harbor Meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee

2004 • 582 citations

The stroma reaction myofibroblast: a key player in the control of tumor cell behavior

2004 • 543 citations

Role of the stromal microenvironment in carcinogenesis of the prostate

2003 • 362 citations

ADAM 12-S Cleaves IGFBP-3 and IGFBP-5 and Is Inhibited by TIMP-3

2000 • 309 citations

Cysteine-Rich Domain of Human ADAM 12 (Meltrin α) Supports Tumor Cell Adhesion

1999 • 209 citations

ADAM12 in human liver cancers: TGF-β-regulated expression in stellate cells is associated with matrix remodeling

2003 • 195 citations

ADAM12 Is Selectively Overexpressed in Human Glioblastomas and Is Associated with Glioblastoma Cell Proliferation and Shedding of Heparin-Binding Epidermal Growth Factor

2004 • 150 citations

A Role for ADAM12 in Breast Tumor Progression and Stromal Cell Apoptosis

2005 • 138 citations

Critical Function for ADAM9 in Mouse Prostate Cancer

2005 • 113 citations

Spatially- and temporally-restricted expression of meltrin α (ADAM12) and β (ADAM19) in mouse embryo

1998 • 102 citations

c-kit receptor and ligand expression in postnatal development of the mouse cerebellum suggests a function for c-kit in inhibitory interneurons

1992 • 81 citations

Androgens and transforming growth factor β modulate the growth response to epidermal growth factor in human prostatic tumor cells (LNCaP)

1988 • 61 citations

Heparin-Binding Epidermal Growth Factor-Like Growth Factor Stimulates Androgen-Independent Prostate Tumor Growth and Antagonizes Androgen Receptor Function

2002 • 58 citations

Heparin-binding EGF-like growth factor in the human prostate: Synthesis predominantly by interstitial and vascular smooth muscle cells and action as a carcinoma cell mitogen

1998 • 45 citations

Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate

2004 • 33 citations

Possible autocrine loop of the epidermal growth factor system in patients with benign prostatic hyperplasia treated with finasteride: a placebo‐controlled randomized study

2002 • 11 citations