(Make) Stick and cut loose—Disintegrin metalloproteases in development and disease

New functions for the matrix metalloproteinases in cancer progression

2002 • 5,937 citations

Alzheimer's Disease: Genes, Proteins, and Therapy

2001 • 5,919 citations

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 • 1,607 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

Regulated Intramembrane Proteolysis

2000 • 1,314 citations

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

1999 • 1,115 citations

Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness

2002 • 1,108 citations

A Novel Proteolytic Cleavage Involved in Notch Signaling

2000 • 1,080 citations

ADAMs: key components in EGFR signalling and development

2005 • 1,056 citations

The ADAMs family of metalloproteases: multidomain proteins with multiple functions

2003 • 1,052 citations

Notch signaling is essential for vascular morphogenesis in mice

2000 • 1,042 citations

The selecting: vascular adhesion molecules

1995 • 954 citations

Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

1998 • 922 citations

Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

2002 • 846 citations

A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1

2000 • 841 citations

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10

2001 • 788 citations

Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

2002 • 727 citations

TNF Receptor-Deficient Mice Reveal Divergent Roles for p55 and p75 in Several Models of Inflammation

1998 • 715 citations

Developmental Defects in Mouse Embryos Lacking N-Cadherin

1997 • 712 citations

Lack of β-catenin affects mouse development at gastrulation

1995 • 700 citations

A potential fusion peptide and an integrin ligand domain in a protein active in sperm–egg fusion

1992 • 680 citations

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

2002 • 657 citations

Membrane protein secretases

1997 • 634 citations

ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and β-catenin translocation

2005 • 630 citations

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

2004 • 609 citations

γ-Secretase: proteasome of the membrane?

2004 • 543 citations

Regulated Cleavage of a Contact-Mediated Axon Repellent

2000 • 522 citations

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1999 • 517 citations

Kuzbanian Controls Proteolytic Processing of Notch and Mediates Lateral Inhibition during Drosophila and Vertebrate Neurogenesis

1997 • 516 citations

ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions.

1995 • 507 citations

Fertilization Defects in Sperm from Mice Lacking Fertilin β

1998 • 497 citations

A metalloprotease-disintegrin participating in myoblast fusion

1995 • 492 citations

Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone

2000 • 476 citations

ADAM10 cleavage of N-cadherin and regulation of cell–cell adhesion and β-catenin nuclear signalling

2005 • 470 citations

A CBP Binding Transcriptional Repressor Produced by the PS1/ϵ-Cleavage of N-Cadherin Is Inhibited by PS1 FAD Mutations

2003 • 468 citations

Mice lacking both presenilin genes exhibitearlyembryonic patterningdefects

1999 • 462 citations

Shedding light on ADAM metalloproteinases

2005 • 449 citations

Cholesterol Modulates α-Secretase Cleavage of Amyloid Precursor Protein

1996 • 444 citations

Adam Meets Eph: An ADAM Substrate Recognition Module Acts as a Molecular Switch for Ephrin Cleavage In trans

2005 • 434 citations

ADAMs family members as amyloid precursor protein α‐secretases

2003 • 430 citations

Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling

2003 • 414 citations

Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian

1999 • 413 citations

Calcium Depletion Dissociates and Activates Heterodimeric Notch Receptors

2000 • 411 citations

ADAM, a Widely Distributed and Developmentally Regulated Gene Family Encoding Membrane Proteins with A̱Ḏisintegrin A̱nd M̱etalloprotease Domain

1995 • 406 citations

ADAMs: modulators of cell–cell and cell–matrix interactions

2003 • 406 citations

The Transmembrane CXC-Chemokine Ligand 16 Is Induced by IFN-γ and TNF-α and Shed by the Activity of the Disintegrin-Like Metalloproteinase ADAM10

2004 • 397 citations

Increased Activity‐Regulating and Neuroprotective Efficacy of α‐Secretase‐Derived Secreted Amyloid Precursor Protein Conferred by a C‐Terminal Heparin‐Binding Domain

1996 • 387 citations

Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins

2001 • 385 citations

Identification and purification of a sperm surface protein with a potential role in sperm-egg membrane fusion.

1987 • 368 citations

Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

2001 • 357 citations

The Notch Ligands, Jagged and Delta, Are Sequentially Processed by α-Secretase and Presenilin/γ-Secretase and Release Signaling Fragments

2003 • 353 citations

TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

2003 • 342 citations

KUZ, a Conserved Metalloprotease-Disintegrin Protein with Two Roles in Drosophila Neurogenesis

1996 • 331 citations

Protein Kinase C-dependent α-Secretase Competes with β-Secretase for Cleavage of Amyloid-β Precursor Protein in the Trans-Golgi Network

2000 • 320 citations

A Novel, Secreted Form of Human ADAM 12 (Meltrin α) Provokes Myogenesis in Vivo

1998 • 315 citations

Metalloprotease-Disintegrin MDC9: Intracellular Maturation and Catalytic Activity

1999 • 312 citations

Putative function of ADAM9, ADAM10, and ADAM17 as APP -secretase

2003 • 291 citations

Stromelysin‐1: Three‐dimensional structure of the inhibited catalytic domain and of the C‐truncated proenzyme

1995 • 289 citations

Cell–matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation

2004 • 288 citations

Neutrophil rolling altered by inhibition of L-selectin shedding in vitro

1996 • 285 citations

Abnormal TNF activity in Timp3−/− mice leads to chronic hepatic inflammation and failure of liver regeneration

2004 • 277 citations

The putative chaperone calmegin is required for sperm fertility

1997 • 277 citations

Membrane-anchored metalloprotease MDC9 has an α-secretase activity responsible for processing the amyloid precursor protein

1999 • 260 citations

Analysis of Loss of Adhesive Function in Sperm Lacking Cyritestin or Fertilin β

2001 • 258 citations

Neural cell recognition molecule L1: from cell biology to human hereditary brain malformations

1998 • 252 citations

The Cysteine-Rich Domain of Human Adam 12 Supports Cell Adhesion through Syndecans and Triggers Signaling Events That Lead to β1 Integrin–Dependent Cell Spreading

2000 • 246 citations

ADAM 12 Cleaves Extracellular Matrix Proteins and Correlates with Cancer Status and Stage

2004 • 237 citations

Remarkable roles of proteolysis on and beyond the cell surface

2000 • 235 citations

A Role for the Disintegrin Domain of Cyritestin, a Sperm Surface Protein Belonging to the ADAM Family, in Mouse Sperm–Egg Plasma Membrane Adhesion and Fusion

1997 • 235 citations

Protein Ectodomain Shedding

2002 • 234 citations

Presenilin Couples the Paired Phosphorylation of β-Catenin Independent of Axin

2002 • 233 citations

CRASH Syndrome: Clinical Spectrum of Corpus Callosum Hypoplasia, Retardation, Adducted Thumbs, Spastic Paraparesis and Hydrocephalus Due to Mutations in One Single Gene, L1

1995 • 233 citations

Regulation of the α‐secretase ADAM10 by its prodomain and proprotein convertases

2001 • 232 citations

Loss of presenilin 1 is associated with enhanced β-catenin signaling and skin tumorigenesis

2001 • 231 citations

Male Mice Deficient for Germ-Cell Cyritestin Are Infertile1

1999 • 226 citations

kuzbanian-mediated cleavage of Drosophila Notch

2002 • 226 citations

L1 Is Sequentially Processed by Two Differently Activated Metalloproteases and Presenilin/γ-Secretase and Regulates Neural Cell Adhesion, Cell Migration, and Neurite Outgrowth

2005 • 222 citations

Specific Interaction of the Recombinant Disintegrin-like Domain of MDC-15 (Metargidin, ADAM-15) with Integrin αvβ3

1998 • 214 citations

MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains.

1996 • 213 citations

RGD-independent Binding of Integrin α9β1 to the ADAM-12 and -15 Disintegrin Domains Mediates Cell-Cell Interaction

2000 • 211 citations

Presenilin 1 Negatively Regulates β-Catenin/T Cell Factor/Lymphoid Enhancer Factor-1 Signaling Independently of β-Amyloid Precursor Protein and Notch Processing

2001 • 210 citations

Mice Lacking the Metalloprotease-Disintegrin MDC9 (ADAM9) Have No Evident Major Abnormalities during Development or Adult Life

2002 • 209 citations

Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging

2004 • 204 citations

Secretion of Tumor Necrosis Factor-α from Human Placental Tissues Induced by Hypoxia-Reoxygenation Causes Endothelial Cell Activation in Vitro

2004 • 203 citations

Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes

2002 • 203 citations

Touch and go: guidance cues signal to the growth cone cytoskeleton

2005 • 196 citations

ADAM12 in human liver cancers: TGF-β-regulated expression in stellate cells is associated with matrix remodeling

2003 • 195 citations

Interaction of metargidin (ADAM-15) with αvβ3 and α5β1 integrins on different haemopoietic cells

1999 • 193 citations

Meltrin γ (ADAM-9) mediates cellular adhesion through α6β1 integrin, leading to a marked induction of fibroblast cell motility

2000 • 190 citations

Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway.

1999 • 189 citations

Possible Function of the ADAM1a/ADAM2 Fertilin Complex in the Appearance of ADAM3 on the Sperm Surface

2004 • 188 citations

Role of Src Kinases in the ADAM-mediated Release of L1 Adhesion Molecule from Human Tumor Cells

2000 • 186 citations

The cell surface metalloprotease/disintegrin Kuzbanian is required for axonal extension in Drosophila

1996 • 183 citations

Potential Role for ADAM15 in Pathological Neovascularization in Mice

2003 • 182 citations

ADAM 12, a Disintegrin Metalloprotease, Interacts with Insulin-like Growth Factor-binding Protein-3

2000 • 182 citations

Coordinated Expression of β‐Amyloid Precursor Protein and the Putative β‐Secretase BACE and α‐Secretase ADAM10 in Mouse and Human Brain

2000 • 179 citations

CRASH Syndrome: Mutations in L1CAM Correlate with Severity of the Disease

1997 • 178 citations

TACE/ADAM17 Processing of EGFR Ligands Indicates a Role as a Physiological Convertase

2003 • 178 citations

Decreased α-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's diseas

1995 • 173 citations

Metargidin, a Membrane-anchored Metalloprotease-Disintegrin Protein with an RGD Integrin Binding Sequence

1996 • 170 citations

Intracellular Maturation of the Mouse Metalloprotease Disintegrin MDC15

1998 • 167 citations

Xenopus ADAM 13 is a metalloprotease required for cranial neural crest-cell migration

2001 • 162 citations

The Metalloprotease Disintegrin ADAM8

2002 • 159 citations

Functional Classification of ADAMs Based on a Conserved Motif for Binding to Integrin α9β1

2002 • 159 citations

Immobilized Arg-Gly-Asp (RGD) peptides of varying lengths as structural probes of the platelet glycoprotein IIb/IIIa receptor

1992 • 158 citations

Clinical Significance of Heparin-Binding Epidermal Growth Factor–Like Growth Factor and A Disintegrin and Metalloprotease 17 Expression in Human Ovarian Cancer

2005 • 158 citations

Presenilin 1 Facilitates the Constitutive Turnover of β-Catenin: Differential Activity of Alzheimer’s Disease–Linked PS1 Mutants in the β-Catenin–Signaling Pathway

1999 • 156 citations

Increased expression of ADAM family members in human breast cancer and breast cancer cell lines

2004 • 156 citations

Specific Sequence Elements Are Required for the Expression of Functional Tumor Necrosis Factor-α-converting Enzyme (TACE)

1999 • 156 citations

Role of matrix metalloproteinases in asthma

2003 • 155 citations

Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice.

2005 • 155 citations

The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer

2005 • 155 citations

IL-8 promotes cell proliferation and migration through metalloproteinase-cleavage proHB-EGF in human colon carcinoma cells

2005 • 155 citations

SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling

1997 • 155 citations

Binding of ADAM12, a Marker of Skeletal Muscle Regeneration, to the Muscle-specific Actin-binding Protein, α-Actinin-2, Is Required for Myoblast Fusion

2000 • 154 citations

Evaluation of the contributions of ADAMs 9, 12, 15, 17, and 19 to heart development and ectodomain shedding of neuregulins β1 and β2

2005 • 153 citations

ADAM12 Is Selectively Overexpressed in Human Glioblastomas and Is Associated with Glioblastoma Cell Proliferation and Shedding of Heparin-Binding Epidermal Growth Factor

2004 • 150 citations

Phenotypic Analysis of Meltrin α (ADAM12)-Deficient Mice: Involvement of Meltrin α in Adipogenesis and Myogenesis

2002 • 145 citations

Fertilin β and other ADAMs as integrin ligands: insights into cell adhesion and fertilization

2001 • 145 citations

Constitutive and Induced CD44 Shedding by ADAM-Like Proteases and Membrane-Type 1 Matrix Metalloproteinase

2004 • 141 citations

ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating β1 integrin function

2003 • 140 citations

Neural cell adhesion molecule L1: Signaling pathways and growth cone motility

1997 • 139 citations

Structure, function and evolutionary relationship of proteins containing a disintegrin domain

1992 • 138 citations

Expression of ADAM‐9 mRNA and protein in human breast cancer

2003 • 138 citations

Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies

2003 • 137 citations

Notch-induced Proteolysis and Nuclear Localization of the Delta Ligand

2003 • 136 citations

Overexpression of ADAM9 in Non-Small Cell Lung Cancer Correlates with Brain Metastasis

2004 • 135 citations

Calmegin Is Required for Fertilin α/β Heterodimerization and Sperm Fertility

2001 • 133 citations

Metalloproteinases, inflammation, and rheumatoid arthritis

2003 • 133 citations

ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma

2004 • 133 citations

Essential Role for ADAM19 in Cardiovascular Morphogenesis

2003 • 131 citations

TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha.

1998 • 130 citations

Reduction of the Disintegrin and Metalloprotease ADAM12 in Preeclampsia

2005 • 129 citations

How actin filaments and microtubules steer growth cones to their targets

2003 • 128 citations

Regulation of Human ADAM 12 Protease by the Prodomain

1999 • 125 citations

Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28

2000 • 123 citations

The Search for α-Secretase and its Potential as a Therapeutic Approach to Alzheimer's Disease

2002 • 123 citations

ADAM33 polymorphisms and phenotype associations in childhood asthma

2004 • 123 citations

Sequence-Specific Interaction between the Disintegrin Domain of Mouse ADAM 3 and Murine Eggs: Role of β1 Integrin-associated Proteins CD9, CD81, and CD98

2001 • 122 citations

Alzheimer's Amyloid Precursor Protein α-Secretase Is Inhibited by Hydroxamic Acid-Based Zinc Metalloprotease Inhibitors: Similarities to the Angiotensin Converting Enzyme Secretase

1998 • 122 citations

Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity

2002 • 121 citations

Constitutive Proteolysis of the ErbB-4 Receptor Tyrosine Kinase by a Unique, Sequential Mechanism

1997 • 117 citations

The Role of ADAM 15 in Glomerular Mesangial Cell Migration

2002 • 117 citations

Pulmonary Hypoplasia in Mice Lacking Tumor Necrosis Factor-α Converting Enzyme Indicates an Indispensable Role for Cell Surface Protein Shedding during Embryonic Lung Branching Morphogenesis

2001 • 117 citations

TACE is required for fetal murine cardiac development and modeling

2003 • 116 citations

The cysteine-rich domain regulates ADAM protease function in vivo

2002 • 115 citations

ADAM 23/MDC3, a Human Disintegrin That Promotes Cell Adhesion via Interaction with the αvβ3 Integrin through an RGD-independent Mechanism

2000 • 115 citations

Metalloprotease‐disintegrin ADAM8: Expression analysis and targeted deletion in mice

2004 • 113 citations

ADAM12/Syndecan-4 Signaling Promotes β1Integrin-dependent Cell Spreading through Protein Kinase Cα and RhoA

2003 • 111 citations

ADAM 13: A Novel ADAM Expressed in Somitic Mesoderm and Neural Crest Cells duringXenopus laevisDevelopment

1997 • 109 citations

Cloning and Initial Characterization of Mouse Meltrin β and Analysis of the Expression of Four MetalloproteaseDisintegrins in Bone Cells

1998 • 109 citations

ADAM12: a novel first‐trimester maternal serum marker for Down syndrome

2003 • 105 citations

CD156 (Human ADAM8): Expression, Primary Amino Acid Sequence, and Gene Location

1997 • 104 citations

A Metalloprotease Disintegrin That Controls Cell Migration in Caenorhabditis elegans

2000 • 104 citations

Down-regulation of Delta by proteolytic processing

2002 • 104 citations

Expression and Regulation of a Disintegrin and Metalloproteinase (ADAM) 8 in Experimental Asthma

2004 • 103 citations

Expression of Members of the Novel Membrane Linked Metalloproteinase Family ADAM in Cells Derived from a Range of Haematological Malignancies

1997 • 102 citations

Spatially- and temporally-restricted expression of meltrin α (ADAM12) and β (ADAM19) in mouse embryo

1998 • 102 citations

Sequence-specific Interaction between the Disintegrin Domain of Mouse ADAM 2 (Fertilin β) and Murine Eggs

2000 • 100 citations

TNF-α Convertase Enzyme from Human Arthritis-Affected Cartilage: Isolation of cDNA by Differential Display, Expression of the Active Enzyme, and Regulation of TNF-α

1998 • 99 citations

Analysis of Mouse Fertilin in Wild-Type and Fertilin β−/− Sperm: Evidence for C-terminal Modification, α/β Dimerization, and Lack of Essential Role of Fertilin α in Sperm–Egg Fusion

2000 • 98 citations

A novel metalloprotease/disintegrin–like gene at 17q21.3 is somatically rearranged in two primary breast cancers

1993 • 97 citations

A secreted form of human ADAM9 has an α-secretase activity for APP

2002 • 96 citations

Essential roles of Meltrin β (ADAM19) in heart development

2003 • 95 citations

Expression of the Disintegrin Metalloprotease, ADAM-10, in Prostate Cancer and Its Regulation by Dihydrotestosterone, Insulin-Like Growth Factor I, and Epidermal Growth Factor in the Prostate Cancer Cell Model LNCaP

2004 • 94 citations

Mutant forms of tumour necrosis factor receptor I that occur in TNF‐receptor‐associated periodic syndrome retain signalling functions but show abnormal behaviour

2004 • 94 citations

Selective Modulation of Integrin-mediated Cell Migration by Distinct ADAM Family Members

2005 • 93 citations

The Splicing and Fate of ADAM33 Transcripts in Primary Human Airways Fibroblasts

2004 • 91 citations

The role of cell adhesion molecule L1 in axonal extension, growth cone motility, and signal transduction

1997 • 89 citations

Pharmacological profile of PKF242‐484 and PKF241‐466, novel dual inhibitors of TNF‐α converting enzyme and matrix metalloproteinases, in models of airway inflammation

2002 • 89 citations

The human fertilin α gene is non-functional: implications for its proposed role in fertilization

1997 • 89 citations

ADAM13 Disintegrin and Cysteine-rich Domains Bind to the Second Heparin-binding Domain of Fibronectin

2002 • 89 citations

Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain

1998 • 88 citations

Systemic cytokine levels and the effects of etanercept in TNF receptor-associated periodic syndrome (TRAPS) involving a C33Y mutation in TNFRSF1A

2005 • 87 citations

ADAM12 and α₉β₁Integrin Are Instrumental in Human Myogenic Cell Differentiation

2004 • 87 citations

The role of CD40 in CD40L- and antibody-mediated platelet activation

2005 • 87 citations

Metalloproteinase-mediated release of the ectodomain of L1 adhesion molecule

1999 • 87 citations

ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis

2005 • 84 citations

Biochemical and Molecular Characterization of Bovine Fertilin α and β (ADAM 1 and ADAM 2): A Candidate Sperm-Egg Binding/Fusion Complex1

1997 • 84 citations

The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone

2000 • 82 citations

the tumour necrosis factor receptor-associated periodic syndrome: current concepts

2005 • 82 citations

The function of leak and kuzbanian during growth cone and cell migration

2001 • 81 citations

Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice

2004 • 78 citations

Integrin α5β1 and ADAM-17 Interact in Vitro and Co-localize in Migrating HeLa Cells

2004 • 78 citations

Differential modulation of proliferation, matrix metalloproteinase expression and invasion of human head and neck squamous carcinoma cells by c-erbB ligands.

1999 • 76 citations

The ADAMs family of proteins: from basic studies to potential clinical applications

2003 • 76 citations

Small vessel vasculitis and relapsing panniculitis in tumour necrosis factor receptor associated periodic syndrome (TRAPS)

2004 • 75 citations

Analysis of the Roles of RGD-Binding Integrins, α4/α9 Integrins, α6 Integrins, and CD9 in the Interaction of the Fertilin β (ADAM2) Disintegrin Domain with the Mouse Egg Membrane1

2002 • 75 citations

The Lymphocyte Metalloprotease MDC-L (ADAM 28) Is a Ligand for the Integrin α4β1

2002 • 74 citations

Implication of APP Secretases in Notch Signaling

2001 • 74 citations

UNC-71, a disintegrin and metalloprotease (ADAM) protein, regulates motor axon guidance and sex myoblast migration inC. elegans

2003 • 73 citations

Catalytic activity of ADAM28

2001 • 72 citations

Role of Slit proteins in the vertebrate brain

2002 • 72 citations

Lack of Tissue Inhibitor of Metalloproteinases-3 Results in an Enhanced Inflammatory Response in Antigen-Induced Arthritis

2005 • 71 citations

ADAM7, A Member of the ADAM (A Disintegrin And Metalloprotease) Gene Family Is Specifically Expressed in the Mouse Anterior Pituitary and Epididymis¹

1997 • 71 citations

MDC-L, a Novel Metalloprotease Disintegrin Cysteine-rich Protein Family Member Expressed by Human Lymphocytes

1999 • 70 citations

Characterization of the Binding of Recombinant Mouse Sperm Fertilin α Subunit to Mouse Eggs: Evidence for Function as a Cell Adhesion Molecule in Sperm-Egg Binding

1997 • 70 citations

Identification of Metalloprotease/Disintegrins inXenopus laevisTestis with a Potential Role in Fertilization

1997 • 69 citations

ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation

2005 • 67 citations

Involvement of ADAM9 in Multinucleated Giant Cell Formation of Blood Monocytes

2001 • 66 citations

ADAM-Integrin Interactions: Potential Integrin Regulated Ectodomain Shedding Activity

2005 • 65 citations

Isolation of Two Novel Metalloproteinase-Disintegrin (ADAM) cDNAs That Show Testis-Specific Gene Expression

1999 • 65 citations

Human Metalloprotease-Disintegrin Kuzbanian Regulates Sympathoadrenal Cell Fate in Development and Neoplasia

1998 • 64 citations

IMPLICATION OF TNF-α CONVERTASE (TACE/ADAM17) IN INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSION AND INFLAMMATION IN AN EXPERIMENTAL MODEL OF COLITIS

2001 • 64 citations

In situ localization of TNFα/β, TACE AND TNF receptors TNF-R1 and TNF-R2 in control and LPS-treated lung tissue

2003 • 64 citations

Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased 7 integrin, utrophin and associated glycoproteins

2003 • 63 citations

Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23

1999 • 63 citations

ADAM disintegrin-like domain recognition by the lymphocyte integrins α4β1 and α4β7

2005 • 63 citations

ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-α

1998 • 62 citations

Disintegrin-like/Cysteine-Rich Region of ADAM 12 Is an Active Cell Adhesion Domain

1999 • 60 citations

Chemotactic agents induce IL-6Rα shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-α-converting enzyme (TACE) type

2002 • 59 citations

Cancer Gene Therapy with Tissue Inhibitors of Metalloproteinases (TIMPs)

2002 • 58 citations

Increased expression of disintegrin‐metalloproteinases ADAM‐15 and ADAM‐9 following upregulation of integrins α5β1 and αvβ3 in atherosclerosis

2003 • 58 citations

Expression and localization of tumour necrosis factor-α and its converting enzyme in human abdominal aortic aneurysm

2004 • 57 citations

Molecular, biochemical, and cellular characterization of epididymal ADAMs, ADAM7 and ADAM28

2005 • 56 citations

Decreased in vitro fertilization efficiencies in the presence of specific cyritestin peptides

1997 • 54 citations

Role for ADAM-family proteinases as membrane protein secretases

1999 • 54 citations

Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE

2005 • 53 citations

The level of ADAM12-S in maternal serum is an early first-trimester marker of fetal trisomy 18

2005 • 53 citations

ADAM15 Is an Adherens Junction Molecule Whose Surface Expression Can Be Driven by VE-Cadherin

2002 • 53 citations

Role of multiple β1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3

2003 • 52 citations

Amyloid-β neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity

2005 • 52 citations

Differential localization of ADAM1a and ADAM1b in the endoplasmic reticulum of testicular germ cells and on the surface of epididymal sperm

2003 • 51 citations

Presenilins and the intramembrane proteolysis of proteins: facts and fiction

2001 • 50 citations

ADAM-17-independent shedding of L-selectin

2003 • 49 citations

Skeletal muscle cell hypertrophy induced by inhibitors of metalloproteases; myostatin as a potential mediator

2001 • 48 citations

Synthesis, Processing, and Subcellular Localization of Mouse ADAM3 during Spermatogenesis and Epididymal Sperm Transport

2004 • 46 citations

The disintegrin domain of ADAM9: a ligand for multiple β1 renal integrins

2005 • 46 citations

Blastocyst-dependent upregulation of metalloproteinase/disintegrin MDC9 expression in rabbit endometrium

1998 • 46 citations

Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization

1999 • 45 citations

A novel mutation (T61I) in the gene encoding tumour necrosis factor receptor superfamily 1A (TNFRSF1A) in a Japanese patient with tumour necrosis factor receptor-associated periodic syndrome (TRAPS) associated with systemic lupus erythematosus

2004 • 45 citations

Heparin-binding EGF-like growth factor in the human prostate: Synthesis predominantly by interstitial and vascular smooth muscle cells and action as a carcinoma cell mitogen

1998 • 45 citations

Human cyritestin genes (CYRN1 and CYRN2) are non-functional

2001 • 44 citations

ADAM23 is a cell‐surface glycoprotein expressed by central nervous system neurons

2004 • 43 citations

Analysis of Fertilin α (ADAM1)-mediated Sperm-Egg Cell Adhesion during Fertilization and Identification of an Adhesion-mediating Sequence in the Disintegrin-like Domain

2001 • 43 citations

Analysis for transcript expression of meltrin alpha in normal, regenerating, and denervated rat muscle.

2000 • 41 citations

Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen

2004 • 40 citations

Molecular Cloning of the Human Fertilin β Subunit

1996 • 39 citations

Therapeutic Potential of TACE Inhibitors in Stroke

2005 • 39 citations

The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries

1999 • 39 citations

Zinc metalloproteinase-mediated cleavage of the human Nogo-66 receptor

2004 • 38 citations

The ADAM Family of Proteases

2005 • 38 citations

CD156 Transgenic Mice

2002 • 37 citations

Importance of Tumor Necrosis Factor-α Cleavage Process in Post-Transplantation Lung Injury in Rats

2004 • 36 citations

ADAM metalloproteases and EGFR signalling

2003 • 36 citations

Analysis of transcripts encoding novel members of the mammalian metalloprotease-like, disintegrin-like, cysteine-rich (MDC) protein family and their expression in reproductive and non-reproductive monkey tissues

1995 • 34 citations

Autolytic Processing at Glu586-Ser587within the Cysteine-rich Domain of Human Adamalysin 19/Disintegrin-Metalloproteinase 19 Is Necessary for Its Proteolytic Activity

2002 • 34 citations

Sequence and expression of a monkey testicular transcript encoding tMDC I, a novel member of the metalloproteinase-like, disintegrin-like, cysteine-rich (MDC) protein family

1994 • 32 citations

Developmental regulation and neuronal expression of the cellular disintegrin ADAM11 gene in mouse nervous system

2002 • 32 citations

Human cyritestin genes (CYRN1 and CYRN2) are non-functional

2001 • 31 citations

The ADAM1a and ADAM1b genes, instead of the ADAM1 (fertilin α) gene, are localized on mouse chromosome 5

2002 • 30 citations

Identification and characterization of ADAM32 with testis-predominant gene expression

2003 • 30 citations

Do fertilin beta and cyritestin play a major role in mammalian sperm-oolemma interactions? A critical re-evaluation of the use of peptide mimics in identifying specific oocyte recognition proteins

2001 • 29 citations

TACE inhibition: a new approach to treating inflammation

2002 • 29 citations

ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3

2005 • 29 citations

Chromosomal Assignment of Four Testis-Expressed Mouse Genes from a New Family of Transmembrane Proteins (ADAMs) Involved in Cell–Cell Adhesion and Fusion

1996 • 28 citations

ADAM 33 and Its Association With Airway Remodeling and Hyperresponsiveness in Asthma

2004 • 27 citations

ADAM23 methylation and expression analysis in brain tumors

2005 • 25 citations

Genetic evidence for an additional member of the metalloproteinase-like, disintegrin-like, cysteine-rich (MDC) family of mammalian proteins and its abundant expression in the testis

1994 • 25 citations

Human tMDC III: a sperm protein with a potential role in oocyte recognition

2002 • 23 citations

Cloning and Characterization of a Complementary DNA Encoding a Human Epididymis-Associated Disintegrin and Metalloprotease 7 Protein1

2001 • 23 citations

Expression of adamalysin 19/ADAM19 in the endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy

2005 • 22 citations

A novel metalloproteinase originally isolated from brain myelin membranes is present in many tissues

1990 • 22 citations

Expression of meltrin-α mRNA is not restricted to fusagenic cells

1997 • 22 citations

Molecular Cloning and Mapping of a Novel ADAM Gene (ADAM29) to Human Chromosome 4

1999 • 21 citations

Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains

2003 • 17 citations

Regulated Intramembrane Proteolysis Takes Another Twist

2001 • 16 citations

Transcripts encoding the sperm surface protein tMDC II are non-functional in the human

1999 • 15 citations

Ectodomain shedding of human Nogo-66 receptor homologue-1 by zinc metalloproteinases

2004 • 11 citations

Novel metalloprotease–disintegrin, meltrin ϵ (ADAM35), expressed in epithelial tissues during chick embryogenesis

2004 • 10 citations