ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer

Pancreatic Cancer

2000 • 7,332 citations

Cancer Statistics, 2006

2006 • 5,351 citations

Pancreatic cancer

2004 • 1,663 citations

ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions.

1995 • 507 citations

Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation.

2001 • 329 citations

Metalloproteinases and their inhibitors in tumor angiogenesis

2005 • 300 citations

Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis

2005 • 207 citations

Catalytic Activity of ADAM8, ADAM15, and MDC-L (ADAM28) on Synthetic Peptide Substrates and in Ectodomain Cleavage of CD23

2003 • 176 citations

The Metalloprotease Disintegrin ADAM8

2002 • 159 citations

ADAM8 as a Novel Serological and Histochemical Marker for Lung Cancer

2004 • 145 citations

The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs

2002 • 144 citations

Metalloproteinase Disintegrins ADAM8 and ADAM19 Are Highly Regulated in Human Primary Brain Tumors and their Expression Levels and Activities Are Associated with Invasiveness

2006 • 138 citations

ADAM family proteins in the immune system

1999 • 137 citations

ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma

2004 • 133 citations

Tumor Necrosis Factor α Induces a Metalloprotease-Disintegrin, ADAM8 (CD 156): Implications for Neuron–Glia Interactions during Neurodegeneration

2000 • 132 citations

Pancreatic Cancer

2006 • 127 citations

Molecular cloning of cDNA encoding MS2 antigen, a novel cell surface antigen strongly expressed in murine monocytic lineage

1990 • 124 citations

Ectodomain Shedding of the Neural Recognition Molecule CHL1 by the Metalloprotease-disintegrin ADAM8 Promotes Neurite Outgrowth and Suppresses Neuronal Cell Death

2004 • 122 citations

ADAMs, cell migration and cancer

2006 • 118 citations

ADAM8: A Novel Osteoclast Stimulating Factor

2001 • 106 citations

CD156 (Human ADAM8): Expression, Primary Amino Acid Sequence, and Gene Location

1997 • 104 citations

Expression and Regulation of a Disintegrin and Metalloproteinase (ADAM) 8 in Experimental Asthma

2004 • 103 citations

Oxidative Stress Induces ADAM9 Protein Expression in Human Prostate Cancer Cells

2006 • 99 citations

Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8

2006 • 82 citations

Identification of Genes Differentially Induced by Hypoxia in Pancreatic Cancer Cells

2001 • 81 citations

Aberrant Expression of a Disintegrin and Metalloproteinase 17/Tumor Necrosis Factor-α Converting Enzyme Increases the Malignant Potential in Human Pancreatic Ductal Adenocarcinoma

2006 • 68 citations

THE MEMBRANE PROTEASES ADAMS AND HEPSIN ARE DIFFERENTIALLY EXPRESSED IN RENAL CELL CARCINOMA. ARE THEY POTENTIAL TUMOR MARKERS?

2004 • 50 citations

ADAM8 expression in prostate cancer is associated with parameters of unfavorable prognosis

2006 • 43 citations

Increased expression of ADAM 9 and ADAM 15 mRNA in pancreatic cancer.

2007 • 37 citations

Chronic hypoxia in the human neuroblastoma SH-SY5Y causes reduced expression of the putative α-secretases, ADAM10 and TACE, without altering their mRNA levels

2006 • 36 citations