ADAM-17 Expression in Breast Cancer Correlates with Variables of Tumor Progression

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

ADAMs: key components in EGFR signalling and development

2005 • 1,056 citations

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

2004 • 965 citations

EGF receptor ligands

2003 • 751 citations

Pooled Analysis of Prognostic Impact of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in 8377 Breast Cancer Patients

2002 • 592 citations

Tumor necrosis factor or tumor promoting factor?

2002 • 516 citations

Randomized Adjuvant Chemotherapy Trial in High-Risk, Lymph Node-Negative Breast Cancer Patients Identified by Urokinase-Type Plasminogen Activator and Plasminogen Activator Inhibitor Type 1

2001 • 442 citations

Tumor Necrosis Factor-α Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability

2002 • 415 citations

Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer

2006 • 376 citations

Intracellular maturation and localization of the tumour necrosis factor α convertase (TACE)

2000 • 350 citations

TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

2003 • 342 citations

Tumor necrosis factor-α converting enzyme

2002 • 341 citations

Essential role of tumor necrosis factor alpha (TNF-alpha) in tumor promotion as revealed by TNF-alpha-deficient mice.

1999 • 308 citations

Proliferative markers as prognostic and predictive tools in early breast cancer: where are we now?

2005 • 304 citations

Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion

2003 • 275 citations

ADAM 12 Cleaves Extracellular Matrix Proteins and Correlates with Cancer Status and Stage

2004 • 237 citations

Urokinase Plasminogen Activator and Its Inhibitor, PAI-1, as Prognostic Markers in Breast Cancer: From Pilot to Level 1 Evidence Studies

2002 • 223 citations

A Phase II Study of Etanercept (Enbrel), a Tumor Necrosis Factor α Inhibitor in Patients with Metastatic Breast Cancer

2004 • 193 citations

Potential Role for ADAM15 in Pathological Neovascularization in Mice

2003 • 182 citations

Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells

2006 • 178 citations

Tobacco Smoke-induced Lung Cell Proliferation Mediated by Tumor Necrosis Factor α-converting Enzyme and Amphiregulin

2003 • 172 citations

Distinct ADAM Metalloproteinases Regulate G Protein-coupled Receptor-induced Cell Proliferation and Survival

2004 • 167 citations

Study of Etanercept, a Tumor Necrosis Factor-Alpha Inhibitor, in Recurrent Ovarian Cancer

2005 • 163 citations

Xenopus ADAM 13 is a metalloprotease required for cranial neural crest-cell migration

2001 • 162 citations

Clinical Significance of Heparin-Binding Epidermal Growth Factor–Like Growth Factor and A Disintegrin and Metalloprotease 17 Expression in Human Ovarian Cancer

2005 • 158 citations

Increased expression of ADAM family members in human breast cancer and breast cancer cell lines

2004 • 156 citations

Expression of ADAM‐9 mRNA and protein in human breast cancer

2003 • 138 citations

Up‐regulated expression of ADAM17 in human colon carcinoma: co‐expression with EGFR in neoplastic and endothelial cells

2005 • 135 citations

Therapeutic Benefits from Targeting of ADAM Family Members

2004 • 125 citations

Membrane estrogen receptor-α levels in MCF-7 breast cancer cells predict cAMP and proliferation responses

2004 • 123 citations

The Metallo-Disintegrin ADAM10 (MADM) from Bovine Kidney Has Type IV Collagenase Activityin Vitro

1998 • 121 citations

The Role of ADAM 15 in Glomerular Mesangial Cell Migration

2002 • 117 citations

Critical Function for ADAM9 in Mouse Prostate Cancer

2005 • 113 citations

ADAMs(A Disintegrin and Metalloproteinase) Messenger RNA Expression inHelicobacter pylori–Infected, Normal, and Neoplastic Gastric Mucosa

2002 • 90 citations

Epidermal growth factor receptor‐targeted treatment for advanced colorectal carcinoma

2005 • 78 citations

The ADAMs family of proteins: from basic studies to potential clinical applications

2003 • 76 citations

ADAM17 mRNA expression and pathological features of hepatocellular carcinoma

2004 • 72 citations

Tumor Necrosis Factor-α-Induced Matrix Proteolytic Enzyme Production and Basement Membrane Remodeling by Human Ovarian Surface Epithelial Cells

2004 • 59 citations

Selective inhibition of ADAM metalloproteases blocks HER-2 extracellular domain (ECD) cleavage and potentiates the anti-tumor effects of trastuzumab

2006 • 54 citations

Synthesis and structure–activity relationship of a novel, achiral series of TNF-α converting enzyme inhibitors

2006 • 46 citations

Studies on oestrogen receptor-α and -β mRNA in breast cancer

2001 • 40 citations

Conversion of potent MMP inhibitors into selective TACE inhibitors

2005 • 28 citations

Design and synthesis of butynyloxyphenyl β-sulfone piperidine hydroxamates as TACE inhibitors

2006 • 24 citations

Mammaglobin a in breast cancer: Existence of multiple molecular forms

2004 • 17 citations

Transforming growth factor β‐1 and amphiregulin act in synergy to increase the production of urokinase‐type plasminogen activator in transformed breast epithelial cells

2003 • 16 citations

Editorial [Hot Topic: Latest Developments in the Treatment of Inflammatory Disease (Guest Editor: David Fairlie)]

2005 • 3 citations

Synthesis and Structure—Activity Relationship of a Novel, Achiral Series of TNF‐α Converting Enzyme Inhibitors.

2006 • 1 citations