Regulation of the Nur77 Orphan Steroid Receptor in Activation-Induced Apoptosis

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1992 • 865 citations

Steroid Receptor Family: Structure and Functions

1990 • 820 citations

Negative selection of lymphocytes

1994 • 810 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene

1988 • 661 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Identification of the DNA Binding Site for NGFI-B by Genetic Selection in Yeast

1991 • 566 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.

1995 • 548 citations

Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression.

1992 • 533 citations

A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.

1988 • 532 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

Nuclear factor of activated T cells contains Fos and Jun

1992 • 495 citations

Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors.

1992 • 491 citations

Human SRF-related proteins: DNA-binding properties and potential regulatory targets.

1991 • 446 citations

The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction.

1993 • 397 citations

Identification of a new brain-specific transcription factor, NURR1.

1992 • 373 citations

Effects of Cyclosporine A on T Cell Development and Clonal Deletion

1988 • 354 citations

Identification of Human and Mouse p19, a Novel CDK4 and CDK6 Inhibitor with Homology to p16^ink4

1995 • 336 citations

Participation of Non-Zinc Finger Residues in DNA Binding by Two Nuclear Orphan Receptors

1992 • 323 citations

Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex.

1989 • 315 citations

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

1995 • 305 citations

Abnormal differentiation of thymocytes in mice treated with cyclosporin A

1988 • 281 citations

Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77)

1995 • 273 citations

Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors.

1993 • 267 citations

[2] Chemical properties and separation of phosphoamino acids by thin-layer chromatography and/or electrophoresis

1991 • 246 citations

Phosphorylation of Steroid Hormone Receptors*

1992 • 243 citations

hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors.

1993 • 234 citations

MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex.

1993 • 234 citations

A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage

1993 • 224 citations

A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing.

1994 • 218 citations

Activation-induced cell death in T cell hybridomas is due to apoptosis. Morphologic aspects and DNA fragmentation.

1990 • 201 citations

In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes.

1991 • 199 citations

Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation.

1989 • 194 citations

Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor.

1989 • 188 citations

Molecular Cloning of a Novel Thyroid/Steroid Receptor Superfamily Gene from Cultured Rat Neuronal Cells

1994 • 187 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

Peptides in positive and negative selection: A delicate balance

1994 • 153 citations

Adrenocortical Function and Regulation of the Steroid 21-Hydroxylase Gene in NGFI-B-Deficient Mice

1995 • 146 citations

The NGFI-B protein, an inducible member of the thyroid/steroid receptor family, is rapidly modified posttranslationally.

1990 • 139 citations

RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver.

1993 • 130 citations

Functional domains and phosphorylation of the orphan receptor Nur77.

1993 • 128 citations

9-cis-retinoic acid inhibits activation-driven T-cell apoptosis: implications for retinoid X receptor involvement in thymocyte development.

1993 • 124 citations

The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-B.

1993 • 115 citations

Cloning of GT Box-Binding Proteins: A Novel Spl Multigene Family Regulating T-Cell Receptor Gene Expression

1992 • 114 citations

Domains regulating transcriptional activity of the inducible orphan receptor NGFI-B.

1992 • 110 citations

The cell cycle block and lysis of an activated T cell hybridoma are distinct processes with different Ca2+ requirements and sensitivity to cyclosporine A.

1989 • 110 citations

Nur77 Is Differentially Modified in PC12 Cells upon Membrane Depolarization and Growth Factor Treatment

1991 • 108 citations

Cyclosporin A blocks apoptosis by inhibiting the DNA binding activity of the transcription factor Nur77.

1995 • 99 citations

T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection.

1995 • 97 citations

NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3.

1994 • 95 citations

hMEF2C Gene Encodes Skeletal Muscle- and Brain-Specific Transcription Factors

1993 • 65 citations

Cyclosporin A inhibits positive selection and delays negative selection in alpha beta TCR transgenic mice.

1994 • 64 citations

The Orphan Receptors NGFI-B and Steroidogenic Factor 1 Establish Monomer Binding as a Third Paradigm of Nuclear Receptor-DNA Interaction

1993 • 62 citations

A Mef2 Gene That Generates a Muscle-Specific Isoform via Alternative mRNA Splicing

1994 • 55 citations

Intracellular signaling events during positive and negative selection of CD4+CD8+ thymocytes in vitro.

1995 • 53 citations

cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line.

1995 • 45 citations

The NGFI-B Protein, an Inducible Member of the Thyroid/Steroid Receptor Family, Is Rapidly Modified Posttranslationally

1990 • 39 citations

Effects of cyclosporine A on T cell development and clonal deletion

1988 • 31 citations

Molecular Characterization of the Nur77 Orphan Steroid Receptor in Apoptosis

1994 • 12 citations