Regulations of opioid dependence by opioid receptor types

EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.

1964 • 5,110 citations

Stereotaxic Mapping of the Monoamine Pathways in the Rat Brain*

1971 • 3,816 citations

Drugs of abuse: anatomy, pharmacology and function of reward pathways

1992 • 2,091 citations

Nucleus locus ceruleus: new evidence of anatomical and physiological specificity

1983 • 1,877 citations

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

1996 • 1,652 citations

Central Catecholamine Neuron Systems: Anatomy and Physiology of the Norepinephrine and Epinephrine Systems

1979 • 1,361 citations

Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications

1995 • 1,267 citations

Cloning of a Delta Opioid Receptor by Functional Expression

1992 • 1,225 citations

Ascending Monoamine Neurons to the Telencephalon and Diencephalon

1966 • 1,205 citations

Opioid analgesics and antagonists

1996 • 1,193 citations

Cellular localization of brain monoamines.

1962 • 1,141 citations

Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.

1988 • 913 citations

Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.

1993 • 828 citations

Molecular cloning and functional expression of a mu opioid receptor from rat brain

1994 • 805 citations

Two types of neurone in the rat ventral tegmental area and their synaptic inputs.

1992 • 682 citations

Simultaneous quantitative assessment of morphine tolerance and physical dependence.

1969 • 681 citations

II. New evidence for a locus coeruleus-norepinephrine connection with anxiety

1979 • 666 citations

Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.

1993 • 614 citations

Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type

1994 • 593 citations

Behavioral Analysis of Drug Dependence

1986 • 547 citations

Neurobiology of opiate abuse

1992 • 546 citations

Modulation of Anxiety and Neuropeptide Y-Y1 Receptors by Antisense Oligodeoxynucleotides

1993 • 528 citations

Drug reinforcement studied by the use of place conditioning in rat

1982 • 482 citations

Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats.

1993 • 458 citations

Electrophysiological evidence for excitation of rat ventral tegmental area dopamine neurons by morphine

1984 • 424 citations

Cloning and pharmacological characterization of a rat kappa opioid receptor.

1993 • 422 citations

Disruption of the kappa -opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa -agonist U-50,488H and attenuates morphine withdrawal

1998 • 408 citations

mu opiate receptor: cDNA cloning and expression.

1993 • 405 citations

Role of different brain structures in the expression of the physical morphine withdrawal syndrome.

1992 • 381 citations

Organization of N‐methyl‐D‐aspartate glutamate receptor gene expression in the basal ganglia of the rat

1994 • 368 citations

Enkephalin action on the mesolimbic system: a dopamine-dependent and a dopamine-independent increase in locomotor activity.

1983 • 355 citations

Reinforcing effects of morphine microinjection into the ventral tegmental area

1980 • 334 citations

Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family

1994 • 333 citations

Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes.

1991 • 330 citations

Distinct distributions of five N‐methyl‐<scp>D</scp>‐aspartate receptor channel subunit mRNAs in the forebrain

1993 • 316 citations

Behavioral effects of stimulation of the nucleus locus coeruleus in the stump-tailed monkeyMacaca arctoides

1976 • 302 citations

Opioids, reward and addiction: An encounter of biology, psychology, and medicine.

1999 • 299 citations

Pharmacological characterization in vivo of the novel opiate, beta-funaltrexamine.

1982 • 296 citations

A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities

1980 • 287 citations

Human μ opiate receptor

1994 • 286 citations

Primary structures and expression from cDNAs of rat opioid receptor δ‐and μ‐subtypes

1993 • 277 citations

Examination of the neurochemical substrates mediating the motivational effects of opioids: role of the mesolimbic dopamine system and D-1 vs. D-2 dopamine receptors.

1993 • 274 citations

Modulation of A10 dopamine neurons by gamma-aminobutyric acid agonists.

1990 • 265 citations

Differential antagonism of opioid delta antinociception by [D-Ala2,Leu5,Cys6]enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes.

1991 • 265 citations

Antisense oligonucleotide strategies in neuropharmacology

1994 • 265 citations

Anatomically Distinct Opiate Receptor Fields Mediate Reward and Physical Dependence

1984 • 265 citations

Molecular cloning of a rat κ opioid receptor reveals sequence similarities to the μ and δ opioid receptors

1993 • 254 citations

Reinforcing effects of brain microinjections of morphine revealed by conditioned place preference

1982 • 238 citations

Lack of antinociceptive cross-tolerance between [D-Pen2, D-Pen5]enkephalin and [D-Ala2]deltorphin II in mice: evidence for delta receptor subtypes.

1991 • 231 citations

The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone

1981 • 229 citations

μ-Opposing actions of the κ-opioid receptor

1998 • 221 citations

The development of a conditioned place preference to morphine: Effects of microinjections into various CNS sites.

1997 • 213 citations

The tegmental pedunculopontine nucleus: a brain-stem output of the limbic system critical for the conditioned place preferences produced by morphine and amphetamine

1989 • 206 citations

Common α2- and opiate effector mechanisms in the locus coeruleus: intracellular studies in brain slices

1987 • 202 citations

Molecular cloning and expression of a rat κ opioid receptor

1993 • 198 citations

Evidence that the aversive effects of opioid antagonists and ?-agonists are centrally mediated

1989 • 193 citations

Diversity of agents that modify opioid tolerance, physical dependence, abstinence syndrome, and self-administrative behavior.

1994 • 189 citations

Locomotor activity and antinociception after putative mu, kappa and sigma opioid receptor agonists in the rat: influence of dopaminergic agonists and antagonists.

1981 • 176 citations

The development of a conditioned place preference to morphine: Effects of microinjections into various CNS sites.

1997 • 171 citations

Direct dependence studies in rats with agents selective for different types of opioid receptor.

1988 • 166 citations

Blockade of morphine reward through the activation of κ-opioid receptors in mice

1993 • 164 citations

N-Methyl-d-aspartic acid-receptor antagonists block morphine-induced conditioned place preference in rats

1995 • 159 citations

The primate locus coeruleus and effects of clonidine on opiate withdrawal.

1982 • 137 citations

Autoradiographic analysis of mu1, mu2, and delta opioid binding in the central nervous system of C57BL/6BY and CXBK (opioid receptor-deficient) mice

1985 • 137 citations

Opioid reward mechanisms: a key role in drug abuse?

1998 • 131 citations

Modulation of the potency and efficacy of mu-mediated antinociception by delta agonists in the mouse.

1990 • 113 citations

Effects of the non-competitive NMDA receptor antagonist ifenprodil on the morphine-induced place preference in mice

1999 • 111 citations

Opioid reward mechanisms: a key role in drug abuse?

1998 • 108 citations

Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones

1980 • 103 citations

cDNA cloning and pharmacological characterization of an opioid receptor with high affinities for κ‐subtype‐selective ligands

1993 • 102 citations

Dopaminergic mediation of reward produced by direct injection of enkephalin into the ventral tegmental area of the rat

1983 • 95 citations

Morphine-induced place preference in the CXBK mouse: characteristics of μ opioid receptor subtypes

1993 • 93 citations

Visualization of mu1 opiate receptors in rat brain by using a computerized autoradiographic subtraction technique.

1985 • 93 citations

Cloning, Characterization, and Distribution of a μ-Opioid Receptor in Rat Brain

1994 • 90 citations

Activation of ventral tegmental GABAB receptors inhibits morphine-induced place preference in rats

1996 • 90 citations

Substance P, neurotensin and enkephalin injections into the ventral tegmental area: comparative study on dopamine turnover in several forebrain structures

1989 • 90 citations

Aversive properties of naloxone in non-dependent (naive) rats may involve blockade of central ?-endorphin

1985 • 88 citations

Analgesic, locomotor and lethal effects of morphine in the mouse: Strain comparisons

1985 • 84 citations

Involvement of delta 2 opioid receptors in the development of morphine dependence in mice.

1993 • 83 citations

Behavioral effects of a novel kappa opioid analgesic, U-50488, in rats and rhesus monkeys

1985 • 81 citations

Low doses of methylnaloxonium in the nucleus accumbens antagonize hyperactivity induced by heroin in the rat

1985 • 78 citations

Effects of nor-binaltorphimine on the development of analgesic tolerance to and physical dependence on morphine

1992 • 72 citations

Role of spinal mu opioid receptors in the development of morphine tolerance and dependence.

1984 • 71 citations

Effects of pedunculopontine tegmental nucleus lesions on morphine-induced conditioned place preference and analgesia in the formalin test

1993 • 69 citations

Antagonist properties of eliprodil and other NMDA receptor antagonists at rat NR1A/NR2A and NR1A/NR2B receptors expressed in Xenopus oocytes

1997 • 66 citations

Conditioned place preference produced by intra-hippocampal morphine

1988 • 65 citations

The Cytosolic Acidification in Rat Parotid Cells Is Associated with an Increase in Cytosolic Ca2+ Concentration

1993 • 61 citations

Evidence for the Existence of the β-Endorphin-Sensitive “ε-Opioid Receptor” in the Brain: The Mechanisms of ε-Mediated Antinociception

1998 • 54 citations

Differentiation between mu and kappa receptor-mediated effects in opioid drug discrimination: apparent pA2 analysis.

1987 • 51 citations

An analysis of drug-seeking behavior in animals

1981 • 50 citations

Involvement of δ-opioid receptors in the effects of morphine on locomotor activity and the mesolimbic dopaminergic system in mice

1993 • 50 citations

Behavior of monkeys during opiate withdrawal and locus coeruleus stimulation

1988 • 48 citations

Blockade of δ-Opioid Receptors Prevents Morphine-Induced Place Preference in Mice

1994 • 46 citations

Stable expression and characterization of recombinant human heteromeric N-methyl-D-aspartate receptor subtypes NMDAR1A/2A and NMDAR1A/2B in mammalian cells.

1996 • 45 citations

Involvement of dopamine-dependent and -independent mechanisms in the rewarding effects mediated by δ opioid receptor subtypes in mice

1997 • 44 citations

Does the dexamethasone suppression test have clinical utility in psychiatry?

1985 • 42 citations

Blockade of the morphine-induced increase in turnover of dopamine on the mesolimbic dopaminergic system by κ -opioid receptor activation in mice

1993 • 41 citations

Effects of β-funaltrexamine (β-FNA) on morphine dependence in rats and monkeys

1986 • 39 citations

Neurobiological Mechanisms of Opiate Withdrawal

1996 • 37 citations

Involvement of delta 2 opioid receptors in acute dependence on morphine in mice.

1993 • 33 citations

Antisense oligodeoxynucleotide to δ opioid receptors attenuates morphine dependence in mice

1997 • 30 citations

Effects of a selective κ-opioid agonist, U-50,488H, on morphine dependence in rats

1989 • 29 citations

Effects of κ-Agonist on the Antinociception and Locomotor EnhancingAction Induced by Morphine in Mice

1993 • 29 citations

Involvement of δ1 and δ2 Opioid Receptor Subtypes in the Development of Physical Dependence on Morphine in Mice

1997 • 28 citations

The role of mu1 receptor in physical dependence on morphine using the mu receptor deficient CXBK mouse

1992 • 27 citations

Role of β-adrenoceptors in the expression of morphine withdrawal signs

1994 • 25 citations

The effect of pretreatment with a δ₂‐opioid receptor antisense oligodeoxynucleotide on the recovery from acute antinociceptive tolerance to δ₂‐opioid receptor agonist in the mouse spinal cord

1997 • 12 citations

The Abstinence Syndrome in Long‐Term, High‐Dosage Narcotic Addiction

1968 • 9 citations

Biochemical, functional and behavioral evaluation of a series of novel antipsychotic-like agents.

1983 • 4 citations

Neuropsychopharmacology of Opiate Dependence

1996 • 3 citations

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