Opioid reward mechanisms: a key role in drug abuse?

The neural basis of drug craving: An incentive-sensitization theory of addiction

1993 • 7,074 citations

Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity

1991 • 2,025 citations

Brain Dopamine and Reward

1989 • 1,899 citations

Naltrexone in the Treatment of Alcohol Dependence

1992 • 1,875 citations

Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.

1992 • 1,001 citations

The dopamine hypothesis of the reinforcing properties of cocaine

1991 • 990 citations

Psychotomimesis Mediated by κ Opiate Receptors

1986 • 822 citations

Endogenous opioid systems and alcohol addiction

1997 • 751 citations

Two types of neurone in the rat ventral tegmental area and their synaptic inputs.

1992 • 682 citations

The Effects of Opioid Peptides on Dopamine Release in the Nucleus Accumbens: An In Vivo Microdialysis Study

1990 • 539 citations

Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats

1992 • 525 citations

Morphine-induced activation of A10 dopamine neurons in the rat

1983 • 485 citations

Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats.

1993 • 458 citations

Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

1997 • 435 citations

Alteration of ethanol self-administration by naltrexone

1980 • 402 citations

Drug Addiction: The Yin and Yang of Hedonic Homeostasis

1996 • 345 citations

Heroin Addiction—A Metabolic Disease

1967 • 338 citations

Kappa opioid inhibition of morphine and cocaine self-administration in rats

1995 • 238 citations

Cocaine-induced c-fos messenger RNA is inversely related to dynorphin expression in striatum

1993 • 235 citations

Addiction to Cocaine and Amphetamine

1996 • 234 citations

Repeated cocaine administration upregulates K and μ, but not δ, opioid receptors

1994 • 230 citations

Depression of Mesolimbic Dopamine Transmission and Sensitization to Morphine During Opiate Abstinence

1992 • 224 citations

Importance of delta opioid receptors in maintaining high alcohol drinking

1991 • 220 citations

Sensitization to the conditioned rewarding effects of morphine: pharmacology and temporal characteristics

1996 • 195 citations

Action of drugs of abuse on brain reward systems: An update with specific attention to opiates

1982 • 194 citations

Evidence that the aversive effects of opioid antagonists and ?-agonists are centrally mediated

1989 • 193 citations

Opioid receptor-mediated inhibition of dopamine and acetylcholine release from slices of rat nucleus accumbens, olfactory tubercle and frontal cortex

1990 • 157 citations

Profound depression of mesolimbic dopamine release after morphine withdrawal in dependent rats

1991 • 155 citations

Differences between Alcohol‐Preferring (AA) and Alcohol‐Avoiding (ANA) Rats in the Prodynorphin and Proenkephalin Systems

1994 • 149 citations

Genetic approaches to the analysis of addiction processes

1989 • 147 citations

Involvement of μ-opioid receptors in alcohol drinking by alcohol-preferring AA rats

1993 • 136 citations

Blockade of δ-opioid receptors in the nucleus accumbens prevents ethanol-induced stimulation of dopamine release

1993 • 128 citations

Involvement of central μ and δ opioid receptors in mediating the reinforcing effects of β-endorphin in the rat

1990 • 109 citations

Low endogenous dopamine function in brain predisposes to high alcohol preference and consumption: reversal by increasing synaptic dopamine.

1995 • 103 citations

Persistence of chronic morphine effects upon activity in rats 8 months after ceasing the treatment

1975 • 103 citations

Modulation of drug-induced sensitization processes by endogenous opioid systems

1995 • 101 citations

Dynorphin opioid inhibition of cocaine‐induced, D1 dopamine receptor‐mediated immediatem‐early gene expression in the striatum

1995 • 98 citations

Modulation of morphine-induced sensitization by endogenous κ opioid systems in the rat

1993 • 86 citations

Endogenous opioids and excessive alcohol consumption.

1993 • 78 citations

Identification of the opiosd receptor types mediating β-endorphin-induced alterations in dopamine release in the nucleus accumbens

1990 • 76 citations

Motivational effects of opioids in an animal model of prolonged inflammatory pain: alteration in the effects of κ-but not of μ-receptor agonists

1988 • 68 citations

Tolerance and selective cross-tolerance to the motivational effects of opioids

1988 • 64 citations

Neurobiology of drug abuse.

1987 • 61 citations

The δ-opioid receptor antagonist naltrindole prevents sensitization to the conditioned rewarding effects of cocaine

1995 • 58 citations

Cocaine self-administration and naltrindole, a delta-selective opioid antagonist

1995 • 56 citations

Oral etonitazene and cocaine consumption by AA, ANA and Wistar rats

1993 • 53 citations

Opioids and Motivation

1987 • 17 citations

Some thoughts about endogenous opioids and addiction

1983 • 11 citations

Reward and its control by dynorphin peptides

1994 • 10 citations