VLA-4 integrin mediates lymphocyte migration on the inducible endothelial cell ligand VCAM-1 and the extracellular matrix ligand fibronectin.

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

1986 • 1,206 citations

LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins

1987 • 1,147 citations

An interaction between alpha-actinin and the beta 1 integrin subunit in vitro.

1990 • 851 citations

IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1.

1992 • 838 citations

Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin.

1989 • 807 citations

Specific Acceptance of Cardiac Allograft After Treatment with Antibodies to ICAM-1 and LFA-1

1992 • 737 citations

Integrins as mechanochemical transducers

1991 • 684 citations

Physiological and Molecular Mechanisms of Lymphocyte Homing

1992 • 655 citations

Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1

1990 • 616 citations

Amino acid sequence of the human fibronectin receptor.

1987 • 596 citations

Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells [published erratum appears in Blood 1990 Dec 1;76(11):2420]

1990 • 540 citations

Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1.

1991 • 510 citations

Identification of a murine Peyer's patch—specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA-4α

1989 • 495 citations

The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol ester.

1986 • 487 citations

Ligands “activate” integrin αIIbβ3 (platelet GPIIb-IIIa)

1991 • 481 citations

Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response.

1989 • 416 citations

Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytes.

1991 • 388 citations

Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.

1991 • 367 citations

Roles of Adhesion Molecules in T‐Cell Recognition: Fundamental Similarities between Four Integrins on Resting Human T Cells (LFA‐1, VLA‐4, VLA‐5, VLA‐6) in Expression, Binding, and Costimulation

1990 • 322 citations

Distinct cellular functions mediated by different VLA integrin α subunit cytoplasmic domains

1992 • 307 citations

Vascular and nonvascular expression of INCAM-110. A target for mononuclear leukocyte adhesion in normal and inflamed human tissues.

1991 • 306 citations

Expression of adhesion molecules and chemotactic cytokines in cultured human mesothelial cells.

1992 • 303 citations

Immunolocalization of endothelial and leukocyte adhesion molecules in human rheumatoid and osteoarthritic synovial tissues.

1991 • 295 citations

The role of integrins in the maintenance of endothelial monolayer integrity.

1991 • 290 citations

IL-4 acts synergistically with IL-1 beta to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1.

1990 • 286 citations

Vascular endothelial cell adhesion and spreading promoted by the peptide REDV of the IIICS region of plasma fibronectin is mediated by integrin alpha 4 beta 1.

1992 • 281 citations

Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel.

1989 • 270 citations

Regulation of vascular cell adhesion molecule 1 on human dermal microvascular endothelial cells.

1992 • 268 citations

IL-4 controls the selective endothelium-driven transmigration of eosinophils from allergic individuals.

1992 • 266 citations

Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1.

1993 • 266 citations

The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function.

1989 • 264 citations

Vascular cell adhesion molecule 1 induces T-cell antigen receptor-dependent activation of CD4+T lymphocytes.

1991 • 234 citations

Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY.

1992 • 232 citations

Dynamic membrane-cytoskeletal interactions: specific association of integrin and talin arises in vivo after phorbol ester treatment of peripheral blood lymphocytes.

1988 • 230 citations

Lymphocyte Homing

1989 • 227 citations

Activation of LFA-1 through a Ca2(+)-dependent epitope stimulates lymphocyte adhesion.

1991 • 223 citations

Antibody against the Leu-CAM beta-chain (CD18) promotes both LFA-1- and CR3-dependent adhesion events.

1992 • 223 citations

Expression and regulation of β₇(βp) integrins on mouse lymphocytes: Relevance to the mucosal immune system

1991 • 222 citations

Inhibition of in vivo lymphocyte migration to inflammation and homing to lymphoid tissues by the TA-2 monoclonal antibody. A likely role for VLA-4 in vivo.

1991 • 211 citations

Alpha 4/beta 1 integrin (VLA-4) ligands in arthritis. Vascular cell adhesion molecule-1 expression in synovium and on fibroblast-like synoviocytes.

1992 • 202 citations

Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin.

1991 • 189 citations

The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen dose.

1989 • 166 citations

Molecules and structures involved in the adhesion of natural killer cells to vascular endothelium.

1991 • 163 citations

Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1.

1992 • 163 citations

Coordinate role for cell surface chondroitin sulfate proteoglycan and alpha 4 beta 1 integrin in mediating melanoma cell adhesion to fibronectin.

1992 • 162 citations

Identification of surface proteins mediating adherence of CD11/CD18-deficient lymphoblastoid cells to cultured human endothelium.

1990 • 154 citations

Interaction of leukocyte integrins with ligand is necessary but not sufficient for function.

1992 • 151 citations

Lymphocyte adhesion through very late antigen 4: evidence for a novel binding site in the alternatively spliced domain of vascular cell adhesion molecule 1 and an additional alpha 4 integrin counter-receptor on stimulated endothelium.

1992 • 150 citations

The VLA-4/VCAM-1 pathway is involved in lymphocyte adhesion to endothelium in rheumatoid synovium.

1991 • 147 citations

Cloning and expression of mouse integrin beta p(beta 7): a functional role in Peyer's patch-specific lymphocyte homing.

1992 • 145 citations

Motility of fibronectin receptor-deficient cells on fibronectin and vitronectin: collaborative interactions among integrins [published erratum appears in J Cell Biol 1992 Jul;118(1):217]

1992 • 143 citations

Role of CD11/CD18 in adhesion and transendothelial migration of T cells. Analysis utilizing CD18-deficient T cell clones.

1991 • 136 citations

Tumor cell surface alpha 4 beta 1 integrin mediates adhesion to vascular endothelium: demonstration of an interaction with the N-terminal domains of INCAM-110/VCAM-1.

1991 • 134 citations

Antigen-receptor complex stimulation triggers protein kinase C-dependent CD11a/CD18-cytoskeleton association in T lymphocytes.

1992 • 131 citations

ICAM-1-dependent pathway is critically involved in the pathogenesis of adjuvant arthritis in rats.

1991 • 129 citations

Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes

1991 • 124 citations

Forward transport of glycoproteins on leading lamellipodia in locomoting cells

1989 • 123 citations

Mechanics of fibroblast locomotion: quantitative analysis of forces and motions at the leading lamellas of fibroblasts.

1990 • 122 citations

Transformed human cells release different fibronectin variants than do normal cells.

1986 • 121 citations

Two integrin-binding peptides abrogate T cell-mediated immune responses in vivo.

1991 • 113 citations

Regulation of locomotion and cell-cell contact area by the LFA-1 and ICAM-1 adhesion receptors.

1992 • 112 citations

Neural crest cell locomotion induced by antibodies to β1 integrins A tool for studying the roles of substratum molecular avidity and density in migration

1991 • 106 citations

Transfection of cells from patients with leukocyte adhesion deficiency with an integrin beta subunit (CD18) restores lymphocyte function-associated antigen-1 expression and function.

1990 • 101 citations

Importance of endothelial VCAM-1 for inflammatory leukocytic infiltration in vivo.

1992 • 86 citations

Human melanoma cells with high susceptibility to cell‐mediated lysis can be identified on the basis of icam‐1 phenotype, vla profile and invasive ability

1990 • 79 citations

Suppression of human lymphocyte chemotaxis and transendothelial migration by anti-LFA-1 antibody.

1989 • 77 citations

Induction of VCAM-1 and ICAM-1 on human neural cells and mechanisms of mononuclear leukocyte adherence.

1992 • 76 citations

Mechanisms of lymphocyte homing

1992 • 76 citations

Cloning and sequence analysis of a novel β₂related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains

1990 • 74 citations

Cell-type-specific expression of alternatively spliced human fibronectin IIICS mRNAs.

1990 • 65 citations

Three‐dimensional motility cycle in leukocytes

1992 • 63 citations

Cloning and expression of cDNAs for the alpha subunit of the murine lymphocyte-Peyer's patch adhesion molecule.

1991 • 57 citations

Lymphocyte homing to sites of inflammation

1992 • 55 citations

Fibronectin facilitates the migration of human natural killer cells

1991 • 43 citations

Involvement of beta 2-integrins in the migration of human natural killer cells.

1992 • 42 citations

Lymphocyte adhesion to high endothelium is mediated by two β1 integrin receptors for fibronectin, α4β1 and α5β1

1992 • 40 citations

Molecular cloning of the mouse integrin beta 7 subunit.

1992 • 39 citations

Collagen receptor on T lymphocytes and the control of lymphocyte motility

1989 • 38 citations

Correlation of extracellular matrix components with the cytoarchitecture of mouse Peyer's patches

1992 • 33 citations

Induction of homotypic T cell adhesion by triggering of leukocyte function‐associated antigen‐1α (CD11a): differential effects on resting and activated T cells

1992 • 29 citations

Evidence for involvement of lymphocyte function-associated antigen 1 in T cell migration to epidermis.

1991 • 26 citations

Expression and ligand-binding function of the integrin ?4?1 (VLA-4) on neural-crest-derived tumor cell lines

1992 • 23 citations

Regulation of integrin mobility and cytoskeletal association in normal and RSV-transformed chick embryo fibroblasts

1990 • 16 citations

Haptotactic activity of fibronectin on lymphocyte migration in vitro

1990 • 14 citations

Effect of antigen challenge on lymph node lymphocyte adhesion to vascular endothelial cells and the role of VLA-4 in the rat

1991 • 13 citations