Wnt signaling and dorso-ventral axis specification in vertebrates

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

1996 • 1,827 citations

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

1998 • 1,740 citations

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

1998 • 1,587 citations

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

1998 • 1,244 citations

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

1998 • 1,241 citations

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.

1996 • 1,156 citations

The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

1997 • 908 citations

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

1998 • 850 citations

FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER

1997 • 836 citations

A new secreted protein that binds to Wnt proteins and inhibits their activites

1999 • 706 citations

Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center

1991 • 651 citations

Overexpression of cadherins and underexpression of ?-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

1994 • 647 citations

Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling.

1995 • 545 citations

A β-catenin/XTcf-3 complex binds to thesiamois promoter to regulate dorsal axis specification in Xenopus

1997 • 527 citations

Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis

1989 • 518 citations

β-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos

1996 • 516 citations

Injected Wnt RNA induces a complete body axis in Xenopus embryos

1991 • 501 citations

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

1995 • 492 citations

Axin, a Negative Regulator of the Wnt Signaling Pathway, Directly Interacts with Adenomatous Polyposis Coli and Regulates the Stabilization of β-Catenin

1998 • 489 citations

Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo

1994 • 463 citations

Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.

1993 • 449 citations

A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.

1994 • 449 citations

Regulation of β-Catenin Signaling by the B56 Subunit of Protein Phosphatase 2A

1999 • 423 citations

Cortical rotation of the Xenopus egg: consequences for the anteroposterior pattern of embryonic dorsal development

1989 • 418 citations

Distinct WNT Pathways Regulating AER Formation and Dorsoventral Polarity in the Chick Limb Bud

1998 • 413 citations

Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in β-Catenin That Are Modulated by the Wnt Signaling Pathway

1997 • 404 citations

Analysis of Dishevelled signalling pathways during Xenopus development

1996 • 402 citations

β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation

1999 • 385 citations

Phosphorylation of Axin, a Wnt Signal Negative Regulator, by Glycogen Synthase Kinase-3β Regulates Its Stability

1999 • 365 citations

Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus

1997 • 351 citations

Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos.

1996 • 345 citations

GBP, an Inhibitor of GSK-3, Is Implicated in Xenopus Development and Oncogenesis

1998 • 329 citations

Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

1995 • 321 citations

Xwnt-11: a maternally expressed Xenopus wnt gene

1993 • 308 citations

Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription

1998 • 302 citations

Axin, an inhibitor of the Wnt signalling pathway, interacts with β‐catenin, GSK‐3β and APC and reduces the β‐catenin level

1998 • 294 citations

Domains of Axin Involved in Protein–Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization

1999 • 267 citations

Identification of a Domain of Axin That Binds to the Serine/Threonine Protein Phosphatase 2A and a Self-binding Domain

1999 • 260 citations

Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin

1998 • 258 citations

Interaction of Axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription

1999 • 251 citations

LEF-1/TCF Proteins Mediate Wnt-Inducible Transcription from the Xenopus Nodal-Related 3 Promoter

1997 • 244 citations

Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3

1995 • 233 citations

Wnt and FGF pathways cooperatively pattern anteroposterior neural ectoderm in Xenopus

1997 • 224 citations

The Xenopus homeobox gene Twin mediates Wnt induction of Goosecoid in establishment of Spemann’s organizer

1997 • 220 citations

The homeobox gene Siamois is a target of the Wnt dorsalisation pathway and triggers organiser activity in the absence of mesoderm

1996 • 211 citations

Axil, a Member of the Axin Family, Interacts with Both Glycogen Synthase Kinase 3β and β-Catenin and Inhibits Axis Formation ofXenopus Embryos

1998 • 205 citations

Negative Regulation of Wingless Signaling by D-Axin, a Drosophila Homolog of Axin

1999 • 200 citations

Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled

1995 • 185 citations

The vertebrate organizer: structure and molecules

1996 • 173 citations

Anterior axis duplication in Xenopus induced by the over-expression of the cadherin-binding protein plakoglobin.

1995 • 166 citations

Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis

1998 • 159 citations

β-TrCP is a negative regulator of the Wnt/β-catenin signaling pathway and dorsal axis formation in Xenopus embryos

1998 • 152 citations

Misexpression of Cwnt8C in the mouse induces an ectopic embryonic axis and causes a truncation of the anterior neuroectoderm

1997 • 145 citations

Induction of a secondary embryonic axis in zebrafish occurs following the overexpression of β-catenin

1995 • 136 citations

Effect of Wnt-1 and Related Proteins on Gap Junctional Communication in Xenopus Embryos

1991 • 129 citations

Functional and biochemical interactions of Wnts with FrzA, a secreted Wnt antagonist

1998 • 116 citations

Cooperation between the activin and Wnt pathways in the spatial control of organizer gene expression

1998 • 100 citations

Specific modulation of ectodermal cell fates in Xenopus embryos by glycogen synthase kinase

1995 • 100 citations

Interaction of Wnt and activin in dorsal mesoderm induction in Xenopus

1992 • 89 citations

Wnt signaling and transcriptional control of Siamois in Xenopus embryos

1998 • 88 citations

Animal and vegetal pole cells of early Xenopus embryos respond differently to maternal dorsal determinants: implications for the patterning of the organiser

1997 • 82 citations

Functional Domains of Axin

1999 • 67 citations

Functional Conservation of the Wnt Signaling Pathway Revealed by Ectopic Expression of Drosophila dishevelled in Xenopus

1995 • 58 citations

A role for Xenopus Frizzled 8 in dorsal development

1998 • 49 citations

Evidence for a frizzled-mediated wnt pathway required for zebrafish dorsal mesoderm formation

1998 • 48 citations

Xenopus axin interacts with glycogen synthase kinase-3 beta and is expressed in the anterior midbrain

1999 • 41 citations

Identification of new localized RNAs in theXenopus oocyte by differential display PCR

1996 • 40 citations

Characterization of two frizzled8 homologues expressed in the embryonic shield and prechordal plate of zebrafish embryos1The entire nucleotide sequences for Zfz8a and Zfz8b cDNA were deposited to the GenBank database under the Accession numbers AF060697 and AF060696, respectively.1

1998 • 31 citations

Negative regulation of axis formation and Wnt signaling in Xenopus embryos by the F-box/WD40 protein βTrCP

1999 • 28 citations

Bone Morphogenetic Protein Antagonism of Spemann's Organizer Is Independent of Wnt Signaling

1999 • 10 citations

Identification of new localized RNAs in the Xenopus oocyte by differential display PCR

1996 • 4 citations