Back to search

Ceramide-mediated Macroautophagy Involves Inhibition of Protein Kinase B and Up-regulation of Beclin 1

Data up to Jan 2025

Published2004
Citations422
References78

Total Citations Per Year

Abstract

References (78)

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

Autophagy as a Regulated Pathway of Cellular Degradation

2000 • 3,453 citations

Induction of autophagy and inhibition of tumorigenesis by beclin 1

1999 • 3,194 citations

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

The Role of Polyamines in the Neutralization of Bacteriophage Deoxyribonucleic Acid

1960 • 2,598 citations

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

2003 • 2,136 citations

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

2003 • 2,041 citations

Developmental cell death: morphological diversity and multiple mechanisms

1990 • 1,695 citations

3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

1982 • 1,313 citations

Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast

1998 • 1,271 citations

Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

2003 • 1,214 citations

Molecular dissection of autophagy: two ubiquitin-like systems

2001 • 1,208 citations

The Multiple Roles of PTEN in Tumor Suppression

2000 • 1,150 citations

Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells

2000 • 1,125 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting inSaccharomyces cerevisiae

2001 • 951 citations

A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles.

2001 • 947 citations

The Phosphatidylinositol 3‐Kinase Inhibitors Wortmannin and LY294002 Inhibit Autophagy in Isolated Rat Hepatocytes

1997 • 828 citations

Beclin–phosphatidylinositol 3‐kinase complex functions at the trans ‐Golgi network

2001 • 786 citations

The morphology of various types of cell death in prenatal tissues

1973 • 716 citations

Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles.

1995 • 694 citations

Signal transduction of stress via ceramide

1998 • 687 citations

Phosphorylation of Ribosomal Protein S6 Is Inhibitory for Autophagy in Isolated Rat Hepatocytes

1995 • 654 citations

De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, Pathway

2002 • 603 citations

The autophagosomal–lysosomal compartment in programmed cell death

2001 • 599 citations

The Tumor Suppressor PTEN Positively Regulates Macroautophagy by Inhibiting the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway

2001 • 561 citations

Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

2002 • 527 citations

Autophagy and related mechanisms of lysosome-mediated protein degradation

1994 • 506 citations

Enzymes of Sphingolipid Metabolism: From Modular to Integrative Signaling

2001 • 496 citations

Radiation and ceramide-induced apoptosis

2003 • 487 citations

Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization

1994 • 480 citations

Diversity in the Mechanisms of Neuronal Cell Death

2003 • 468 citations

DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death

2002 • 467 citations

Vacuolar Import of Proteins and Organelles From The Cytoplasm

1999 • 459 citations

Regulation of Insulin-Stimulated Glucose Transporter GLUT4 Translocation and Akt Kinase Activity by Ceramide

1998 • 447 citations

Autophagy and other vacuolar protein degradation mechanisms

1992 • 408 citations

The therapeutic potential of modulating the ceramide/sphingomyelin pathway

2002 • 394 citations

Use of Chromatin Immunoprecipitation To Clone Novel E2F Target Promoters

2001 • 387 citations

Autophagy: a barrier or an adaptive response to cancer

2003 • 364 citations

Inhibition of Akt Kinase by Cell-permeable Ceramide and Its Implications for Ceramide-induced Apoptosis

1998 • 344 citations

The therapeutic potential of modulating the ceramide/sphingomyelin pathway

2002 • 341 citations

Ceramide Disables 3-Phosphoinositide Binding to the Pleckstrin Homology Domain of Protein Kinase B (PKB)/Akt by a PKCζ-Dependent Mechanism

2003 • 339 citations

Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.

2001 • 327 citations

Induction of autophagy by amino-acid deprivation in perfused rat liver

1977 • 323 citations

Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments

2000 • 311 citations

Signalling sphingomyelinases: which, where, how and why?11With the participation of Nathalie Andrieu-Abadie, Nathalie Augé, Bruno Ségui, Emmanuelle Uro-Coste, Robert Salvayre, INSERM Unit 466, Laboratoire de Biochimie, Maladies Métaboliques, Institut Louis Bugnard, Bât. L3, C.H.U. Rangueil, 1 Avenue Jean Poulhès, E 9910 Toulouse Cedex 4, France, and Christine Bezombes, Véronique Mansat-De Mas, INSERM CJF 9503, Institut Claudius Régaud, Toulouse, France.

1999 • 305 citations

Celecoxib Induces Apoptosis by Inhibiting 3-Phosphoinositide-dependent Protein Kinase-1 Activity in the Human Colon Cancer HT-29 Cell Line

2002 • 297 citations

Dissection of Autophagosome Biogenesis into Distinct Nucleation and Expansion Steps

2000 • 280 citations

Ceramide Inhibits Protein Kinase B/Akt by Promoting Dephosphorylation of Serine 473

2000 • 268 citations

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

2001 • 267 citations

The Autophagic and Endocytic Pathways Converge at the Nascent Autophagic Vacuoles

1997 • 265 citations

Autophagy in neurons: a review.

2002 • 247 citations

Ceramide-induced Inhibition of Akt Is Mediated through Protein Kinase Cζ

2002 • 236 citations

Autophagic programmed cell death in Drosophila

2003 • 223 citations

Macroautophagy Is Required for Multicellular Development of the Social Amoeba Dictyostelium discoideum

2003 • 216 citations

Amino Acids and Insulin Control Autophagic Proteolysis through Different Signaling Pathways in Relation to mTOR in Isolated Rat Hepatocytes

2004 • 207 citations

Biochemical Mechanisms of the Generation of Endogenous Long Chain Ceramide in Response to Exogenous Short Chain Ceramide in the A549 Human Lung Adenocarcinoma Cell Line

2002 • 197 citations

The role of sphingolipids in the process of signal transduction

1997 • 190 citations

Chemical Genetic Analysis of Apg1 Reveals A Non-kinase Role in the Induction of Autophagy

2003 • 154 citations

Death-associated Protein (DAP) Kinase Plays a Central Role in Ceramide-induced Apoptosis in Cultured Hippocampal Neurons

2002 • 142 citations

The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically

2003 • 140 citations

Glucosylceramide synthase and apoptosis

2002 • 136 citations

Amino-acid-dependent signal transduction

2000 • 132 citations

Autophagic vacuolar myopathies

2003 • 126 citations

Ultrastructural and Immunocytochemical Characterization of Autophagic Vacuoles in Isolated Hepatocytes: Effects of Vinblastine and Asparagine on Vacuole Distributions

1995 • 124 citations

Disease model: LAMP-2 enlightens Danon disease

2001 • 106 citations

Cellular proteolytic systems

1995 • 83 citations

Amino-acid-dependent signal transduction

2000 • 79 citations

Ceramide induces aSMase expression: implications for oxLDL-induced apoptosis

2001 • 77 citations

Ceramide induces aSMase expression: implications for oxLDL-induced apoptosis

2001 • 64 citations

Ceramide in apoptosis: a revisited role.

2002 • 59 citations

Evidence for acidity of prelysosomal autophagic/endocytic vacuoles (amphisomes)

1993 • 54 citations

The growth arrest and downregulation of c-myc transcription induced by ceramide are related events dependent on p21 induction, Rb underphosphorylation and E2F sequestering

1998 • 49 citations

Use of sphingolipid analogs: benefits and risks1The ganglioside nomenclature is that of Svennerholm, L. (1969) J. Lipid Res. 5, 145–155.1

1999 • 40 citations

Subcellular localization of the Galphai3 protein and G alpha interacting protein, two proteins involved in the control of macroautophagy in human colon cancer HT-29 cells.

1999 • 37 citations

The Metabolism of Sphingo(glyco)lipids is Correlated with the Differentiation‐Dependent Autophagic Pathway in HT‐29 Cells

1996 • 25 citations

Subcellular localization of the Gαi3 protein and G alpha interacting protein, two proteins involved in the control of macroautophagy in human colon cancer HT-29 cells

1999 • 23 citations

Cited By (0)

Loading...
Ceramide-mediated Macroautophagy Involves Inhibition of Protein Kinase B and… (2004) – Journal of Biological Chemistry | Metascience Observatory Explorer