Autophagy and related mechanisms of lysosome-mediated protein degradation

Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae

1993 • 1,649 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction.

1992 • 1,187 citations

A Role for a 70-Kilodalton Heat Shock Protein in Lysosomal Degradation of Intracellular Proteins

1989 • 932 citations

Studies on the mechanisms of autophagy: formation of the autophagic vacuole.

1990 • 789 citations

INTRACELLULAR PROTEASES

1987 • 460 citations

Lysosomes : their role in protein breakdown

1987 • 435 citations

Studies on the mechanisms of autophagy: maturation of the autophagic vacuole.

1990 • 352 citations

Studies on cellular autophagocytosis. The formation of autophagic vacuoles in the liver after glucagon administration.

1968 • 328 citations

A MORPHOMETRIC STUDY OF THE REMOVAL OF PHENOBARBITAL-INDUCED MEMBRANES FROM HEPATOCYTES AFTER CESSATION OF TREATMENT

1973 • 250 citations

The Ways of Endocytosis

1989 • 237 citations

Cytoskeletal changes in hepatocytes induced by Microcystis toxins and their relation to hyperphosphorylation of cell proteins

1992 • 227 citations

Mechanism and regulation of protein degradation in liver

1989 • 220 citations

Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes.

1990 • 218 citations

Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins.

1987 • 197 citations

In exocrine pancreas, the basolateral endocytic pathway converges with the autophagic pathway immediately after the early endosome.

1990 • 196 citations

Degradation and turnover of peroxisomes in the yeast Hansenula polymorpha induced by selective inactivation of peroxisomal enzymes

1983 • 189 citations

Cytoskeletal elements are required for the formation and maturation of autophagic vacuoles

1992 • 185 citations

Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine

1982 • 162 citations

Proteins containing peptide sequences related to Lys-Phe-Glu-Arg-Gln are selectively depleted in liver and heart, but not skeletal muscle, of fasted rats

1991 • 152 citations

Evidence for the regulation of exocytic transport by protein phosphorylation.

1992 • 126 citations

Autophagic vacuoles rapidly fuse with pre-existing lysosomes in cultured hepatocytes

1992 • 124 citations

Selective autophagy of peroxisomes in methylotrophic yeasts.

1993 • 121 citations

The ubiquitin-activating enzyme, E1, is required for stress-induced lysosomal degradation of cellular proteins

1991 • 101 citations

Amino acid and hormonal control of macromolecular turnover in perfused rat liver. Evidence for selective autophagy.

1987 • 99 citations

Endocytosis and transcytosis

1990 • 93 citations

Inhibition of autophagic-lysosomal delivery and autophagic lactolysis by asparagine.

1991 • 91 citations

Ubiquitin-protein conjugates accumulate in the lysosomal system of fibroblasts treated with cysteine proteinase inhibitors

1989 • 91 citations

Membrane markers of endoplasmic reticulum preserved in autophagic vacuolar membranes isolated from leupeptin-administered rat liver.

1991 • 88 citations

Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors

1993 • 87 citations

Ubiquitinated protein conjugates are specifically enriched in the lysosomal system of fibroblasts

1990 • 85 citations

Prelysosomal and lysosomal connections between autophagy and endocytosis

1992 • 81 citations

Inhibition of protein breakdown in cultured cells is a consistent response to growth factors

1980 • 75 citations

A non-autophagic pathway for diversion of ER secretory proteins to lysosomes.

1992 • 72 citations

Autophagic degradation of peroxisomes in isolated rat hepatocytes

1992 • 71 citations

Ubiquitin-activating enzyme, E1, is associated with maturation of autophagic vacuoles.

1992 • 64 citations

The differential degradation of two cytosolic proteins as a tool to monitor autophagy in hepatocytes by immunocytochemistry.

1993 • 53 citations

Quantitative changes in the lysosomal vacuolar system of rat hepatocytes during short-term starvation

1986 • 50 citations

Immunocytochemical study of the surrounding envelope of autophagic vacuoles in cultured rat hepatocytes

1990 • 46 citations

A putative protein-sequestration site involving intermediate filaments for protein degradation by autophagy. Studies with microinjected purified glycolytic enzymes in 3T3-L1 cells

1987 • 45 citations

Immunolocalization of the vacuolar-type (H+)-ATPase from clathrin-coated vesicles.

1991 • 35 citations

Regulation of protein degradation rates in eukaryotes

1989 • 33 citations

Autophagy, cathepsin L transport, and acidification in cultured rat fibroblasts.

1992 • 29 citations

Energy depletion and autophagy. Cytochemical and biochemical studies in isolated rat hepatocytes

1991 • 25 citations

Phalloidin‐induced accumulation of myosin in rat hepatocytes is caused by suppression of autolysosome formation

1990 • 14 citations

Regulation of protein secretion by crinophagy in perfused rat liver.

1991 • 9 citations

Isolation and characterization of crinosomes—A subclass of secondary lysosomes

1989 • 8 citations