Ceramide in apoptosis: a revisited role.

The biochemistry of apoptosis

2000 • 7,314 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice

2001 • 1,245 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

REGULATION OF CERAMIDE PRODUCTION AND APOPTOSIS

1998 • 804 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

Ceramide in the eukaryotic stress response

2000 • 729 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Signal transduction of stress via ceramide

1998 • 687 citations

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival

1999 • 516 citations

Enzymes of Sphingolipid Metabolism: From Modular to Integrative Signaling

2001 • 496 citations

Compartmentalization of ceramide signaling: physical foundations and biological effects

2000 • 421 citations

Lipopolysaccharide Induces Disseminated Endothelial Apoptosis Requiring Ceramide Generation

1997 • 406 citations

FAN, a Novel WD-Repeat Protein, Couples the p55 TNF-Receptor to Neutral Sphingomyelinase

1996 • 390 citations

Ceramide Enables Fas to Cap and Kill

2001 • 377 citations

Glutathione Regulation of Neutral Sphingomyelinase in Tumor Necrosis Factor-α-induced Cell Death

1998 • 345 citations

Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency.

2000 • 344 citations

Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.

2001 • 327 citations

Targeting Ceramide Metabolism--a Strategy for Overcoming Drug Resistance

2001 • 317 citations

Signalling sphingomyelinases: which, where, how and why?11With the participation of Nathalie Andrieu-Abadie, Nathalie Augé, Bruno Ségui, Emmanuelle Uro-Coste, Robert Salvayre, INSERM Unit 466, Laboratoire de Biochimie, Maladies Métaboliques, Institut Louis Bugnard, Bât. L3, C.H.U. Rangueil, 1 Avenue Jean Poulhès, E 9910 Toulouse Cedex 4, France, and Christine Bezombes, Véronique Mansat-De Mas, INSERM CJF 9503, Institut Claudius Régaud, Toulouse, France.

1999 • 305 citations

Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide.

1993 • 305 citations

Ceramide glycosylation potentiates cellular multidrug resistance

2001 • 303 citations

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

1996 • 302 citations

Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.

1995 • 295 citations

Serine Palmitoyltransferase Regulates de NovoCeramide Generation during Etoposide-induced Apoptosis

2000 • 283 citations

Vectorial Budding of Vesicles by Asymmetrical Enzymatic Formation of Ceramide in Giant Liposomes

2000 • 281 citations

Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation

1997 • 278 citations

Activation of Sphingosine Kinase by Tumor Necrosis Factor-α Inhibits Apoptosis in Human Endothelial Cells

1999 • 270 citations

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

2001 • 267 citations

Requirement of an ICE-Like Protease for Induction of Apoptosis and Ceramide Generation by REAPER

1996 • 262 citations

Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway

1997 • 210 citations

Sphingomyelinase Treatment Induces ATP-independent Endocytosis

1998 • 204 citations

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

2000 • 195 citations

Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells

2001 • 193 citations

The role of sphingolipids in the process of signal transduction

1997 • 190 citations

Ceramide in apoptosis—does it really matter?

1998 • 189 citations

Involvement of de NovoCeramide Biosynthesis in Tumor Necrosis Factor-α/Cycloheximide-induced Cerebral Endothelial Cell Death

1998 • 182 citations

Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage–induced apoptosis

1999 • 176 citations

Involvement of Sphingosine in Mitochondria-dependent Fas-induced Apoptosis of Type II Jurkat T Cells

2000 • 176 citations

Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells.

1994 • 169 citations

Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines

1996 • 168 citations

Sphingolipid Mediators in Cardiovascular Cell Biology and Pathology

2001 • 167 citations

Induction of Apoptosis through B-cell Receptor Cross-linking Occurs via de Novo Generated C16-Ceramide and Involves Mitochondria

2001 • 162 citations

Loss of ceramide production confers resistance to radiation-induced apoptosis.

1997 • 162 citations

Phospholipase A2 Is Necessary for Tumor Necrosis Factor α-induced Ceramide Generation in L929 Cells

1997 • 161 citations

Expression of Neutral Sphingomyelinase Identifies a Distinct Pool of Sphingomyelin Involved in Apoptosis

1997 • 159 citations

Induction of apoptotic DNA fragmentation and cell death by natural ceramide

1995 • 158 citations

Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells.

2000 • 156 citations

Cytochrome P450 Epoxygenase Metabolism of Arachidonic Acid Inhibits Apoptosis

2001 • 152 citations

Acidic Sphingomyelinase (ASM) Is Necessary for Fas-induced GD3 Ganglioside Accumulation and Efficient Apoptosis of Lymphoid Cells

1998 • 150 citations

A Novel Cytoplasmic Domain of the p55 Tumor Necrosis Factor Receptor Initiates the Neutral Sphingomyelinase Pathway

1996 • 150 citations

Glutathione peroxidase-1 overexpression prevents ceramide production and partially inhibits apoptosis in doxorubicin-treated human breast carcinoma cells.

2001 • 149 citations

Involvement of the Acid Sphingomyelinase Pathway in UVA-induced Apoptosis

2001 • 147 citations

Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis ofC. neoformans

2001 • 146 citations

Urokinase-type plasminogen activator receptor reversibly dissociates from complement receptor type 3 (alpha M beta 2' CD11b/CD18) during neutrophil polarization.

1996 • 134 citations

CD95-mediated apoptosis in vivo requires acid sphingomyelinase

2000 • 131 citations

Nerve Growth Factor-induced p75-mediated Death of Cultured Hippocampal Neurons Is Age-dependent and Transduced through Ceramide Generated by Neutral Sphingomyelinase

2002 • 127 citations

Resistance to radiation-induced apoptosis in Burkitt's lymphoma cells is associated with defective ceramide signaling.

1997 • 126 citations

Cell Cycle Progression and Cell Polarity Require Sphingolipid Biosynthesis in Aspergillus nidulans

2001 • 124 citations

Restoration of TNF-α-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833

1998 • 117 citations

Killing cancer cells by poly‐drug elevation of ceramide levels

2001 • 116 citations

Anti-immunoglobulin-induced Apoptosis in WEHI 231 Cells Involves the Slow Formation of Ceramide from Sphingomyelin and Is Blocked by bcl-xL

1997 • 114 citations

Involvement of FAN in TNF-induced apoptosis

2001 • 110 citations

Alteration of the Sphingomyelin/Ceramide Pathway Is Associated with Resistance of Human Breast Carcinoma MCF7 Cells to Tumor Necrosis Factor-α-mediated Cytotoxicity

1997 • 106 citations

CD95 (Fas/APO-1) Induces Ceramide Formation and Apoptosis in the Absence of a Functional Acid Sphingomyelinase

1998 • 102 citations

Cell Autonomous Apoptosis Defects in Acid Sphingomyelinase Knockout Fibroblasts

2001 • 97 citations

De Novo Synthesis of Sphingolipids Is Required for Cell Survival by Down-Regulating c-Jun N-Terminal Kinase in Drosophila Imaginal Discs

1999 • 96 citations

Ceramide Mediates Tumor-Induced Dendritic Cell Apoptosis

2001 • 93 citations

Acidic sphingomyelinase-generated ceramide is needed but not sufficient for TNF-induced apoptosis and nuclear factor-kappa B activation.

1996 • 81 citations

Aberrant sphingolipid signaling is involved in the resistance of prostate cancer cell lines to chemotherapy.

1999 • 81 citations

The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin.

1997 • 79 citations

Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation

1998 • 79 citations

Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice

1999 • 76 citations

CD40 Signals Apoptosis through FAN-regulated Activation of the Sphingomyelin-Ceramide Pathway

1999 • 76 citations

Positive feedback control of neutral sphingomyelinase activity by ceramide

1998 • 76 citations

Influence of Bcl-2 overexpression on the ceramide pathway in daunorubicin-induced apoptosis of leukemic cells

1997 • 72 citations

Preferential killing of multidrug-resistant KB cells by inhibitors of glucosylceramide synthase

1999 • 72 citations

Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24)

1996 • 70 citations

Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin

1997 • 66 citations

Stress‐induced apoptosis is not mediated by endolysosomal ceramide

2000 • 62 citations

Biosynthesis of N-Acetylsphingosine by Platelet-activating Factor:Sphingosine CoA-independent Transacetylase in HL-60 Cells

1996 • 62 citations

Lysosomal sphingomyelinase is not solicited for apoptosis signaling

2000 • 56 citations

F-12509A, a New Sphingosine Kinase Inhibitor, Produced by a Discomycete.

2000 • 51 citations

Perturbation of membrane microdomains reduces mitogenic signaling and increases susceptibility to apoptosis after T cell receptor stimulation

2000 • 51 citations

The role of ceramide in receptor- and stress-induced apoptosis studied in acidic ceramidase-deficient Farber disease cells

2001 • 49 citations

Oxidative stress‐induced activation of Lyn recruits sphingomyelinase and is requisite for its stimulation by Ara‐C

2001 • 38 citations

Characterization of B-5354c, a New Sphingosine Kinase Inhibitor, Produced by a Marine Bacterium.

2000 • 37 citations

Acid Sphingomyelinase Activation Requires Caspase-8 but Not P53 nor Reactive Oxygen Species during Fas-Induced Apoptosis in Human Glioma Cells

2002 • 32 citations

Reply to Kolesnick and Hannun, and Perry and Hannun

1999 • 29 citations

Molecular Mechanisms of Apoptosis Induced by an Immunomodulating Peptide on Human Monocytes

2000 • 6 citations