Ceramide induces aSMase expression: implications for oxLDL-induced apoptosis

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

1981 • 8,657 citations

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

1997 • 1,762 citations

Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein.

1995 • 1,170 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

Ceramide in the eukaryotic stress response

2000 • 729 citations

Signal transduction of stress via ceramide

1998 • 687 citations

A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent.

1989 • 594 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha.

1996 • 467 citations

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

1994 • 459 citations

YOPRO-1 permits cytofluorometric analysis of programmed cell death (apoptosis) without interfering with cell viability

1995 • 379 citations

Cathepsin D targeted by acid sphingomyelinase-derived ceramide

1999 • 361 citations

Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency.

2000 • 344 citations

Acidic Sphingomyelinase Mediates Entry of N. gonorrhoeae into Nonphagocytic Cells

1997 • 319 citations

The role of ceramide in cell signaling

1998 • 312 citations

Apoptosis in atherosclerosis: beneficial or detrimental?

2000 • 303 citations

Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis

1997 • 286 citations

Oxidized Low Density Lipoprotein Induces Apoptosis in Cultured Human Umbilical Vein Endothelial Cells by Common and Unique Mechanisms

1998 • 258 citations

Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids

1999 • 176 citations

Overexpression of Acid Ceramidase Protects from Tumor Necrosis Factor–Induced Cell Death

2000 • 174 citations

Signal transduction for nuclear factor-kappa B activation. Proposed location of antioxidant-inhibitable step.

1994 • 158 citations

Lysosomal destabilization during macrophage damage induced by cholesterol oxidation products

2000 • 139 citations

Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependent

1998 • 136 citations

Oxidized low density lipoprotein leads to macrophage accumulation of unesterified cholesterol as a result of lysosomal trapping of the lipoprotein hydrolyzed cholesteryl ester.

1994 • 83 citations

Potential Role for Ceramide in Mitogen-activated Protein Kinase Activation and Proliferation of Vascular Smooth Muscle Cells Induced by Oxidized Low Density Lipoprotein

1998 • 80 citations

Natural ceramide is unable to escape the lysosome, in contrast to a fluorescent analogue

1998 • 77 citations

Positive feedback control of neutral sphingomyelinase activity by ceramide

1998 • 76 citations

Cytotoxicity of oxidized low‐density lipoprotein to mouse peritoneal macrophages: An ultrastructural study

1993 • 73 citations

Mucopolysaccharidosis VII: ?-Glucuronidase deficiency

1974 • 67 citations

The Human Immunodeficiency Virus-1 Tat Protein Increases Cell Proliferation, Alters Sensitivity to Zinc Chelator-Induced Apoptosis, and Changes Sp1 DNA Binding in HeLa Cells

1999 • 63 citations

Sphingolipide – ihre Stoffwechselwege und die Pathobiochemie neurodegenerativer Erkrankungen

1999 • 62 citations

Transcription factors Sp1 and AP-2 mediate induction of acid sphingomyelinase during monocytic differentiation

1999 • 61 citations

Redox Modulation of AP-2 DNA Binding Activityin Vitro

1998 • 58 citations

Modulating Apoptosis: Current Applications and Prospects for Future Drug Development

1999 • 52 citations

Modified low density lipoprotein delivers substrate for ceramide formation and stimulates the sphingomyelin‐ceramide pathway in human macrophages

1997 • 45 citations

Exchange of C₁₆-Ceramide between Phospholipid Vesicles

1999 • 41 citations

Inducible Expression of Manganese Superoxide Dismutase by Phorbol 12-Myristate 13-Acetate Is Mediated by Sp1 in Endothelial Cells

2000 • 41 citations

Oxidized Low-Density Lipoprotein Stimulates Protein Kinase C (PKC) and Induces Expression of PKC-Isotypes via Prostaglandin-H-Synthase in P388D₁Macrophage-Like Cells

1996 • 40 citations

Modulation of the Ceramide Level, A Novel Therapeutic Concept

2000 • 36 citations

Involvement of Caspase-3 and GD3 Ganglioside in Ceramide-induced Apoptosis in Farber Disease

2000 • 35 citations

Cell death induced by peroxidized low-density lipoprotein: endopepsis.

1994 • 32 citations

Low density lipoprotein for oxidation and metabolic studies. Isolation from small volumes of plasma using a tabletop ultracentrifuge.

1995 • 28 citations

Niemann–Pick Human Lymphoblasts Are Resistant to Phthalocyanine 4-Photodynamic Therapy-Induced Apoptosis

1999 • 26 citations

CD95: more than just a death factor?

2000 • 18 citations

Effects of lysosomotropic agents on lipogenesis

1986 • 14 citations

Effect of alterations of blood cholesterol levels on macrophages in the myocardium of New Zealand White rabbits

1997 • 13 citations

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