Advances in the understanding of susceptibility to treatment‐related acute myeloid leukaemia

The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

1995 • 3,492 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

2001 • 2,120 citations

A Second Common Mutation in the Methylenetetrahydrofolate Reductase Gene: An Additional Risk Factor for Neural-Tube Defects?

1998 • 1,569 citations

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

1999 • 1,322 citations

Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism

1994 • 1,319 citations

A Second Genetic Polymorphism in Methylenetetrahydrofolate Reductase (MTHFR) Associated with Decreased Enzyme Activity

1998 • 1,283 citations

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

1994 • 958 citations

Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

1998 • 793 citations

Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.

1996 • 775 citations

Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans.

1998 • 775 citations

Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion.

1988 • 753 citations

Molecular Cloning, Characterization, and Expression in Escherichia coli of Full-length cDNAs of Three Human Glutathione S-Transferase Pi Gene Variants

1997 • 716 citations

Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution

1998 • 678 citations

Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1

1991 • 671 citations

Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series

2003 • 666 citations

XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency.

1999 • 575 citations

The role of double-strand break repair — insights from human genetics

2005 • 560 citations

Functional Analysis and DNA Polymorphism of the Tandemly Repeated Sequences in the 5'-terminal Regulatory Region of the Human Gene for Thymidylate Synthase.

1995 • 553 citations

Role of the human RAD51 protein in homologous recombination and double-stranded-break repair

1998 • 550 citations

XRCC2 and XRCC3, New Human Rad51-Family Members, Promote Chromosome Stability and Protect against DNA Cross-Links and Other Damages

1998 • 530 citations

Genetic Polymorphisms in the Base Excision Repair Pathway and Cancer Risk: A HuGE Review

2005 • 521 citations

XRCC1, XRCC3, XPD gene polymorphisms, smoking and 32P-DNA adducts in a sample of healthy subjects

2001 • 490 citations

RESPONSE: Re: Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4

1999 • 478 citations

An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III.

1994 • 477 citations

Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability

2005 • 476 citations

Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells

2000 • 461 citations

Naturally Occurring Human Glutathione S‐transferase GSTP1‐1 Isoforms with Isoleucine and Valine in Position 104 Differ in Enzymic Properties

1994 • 451 citations

XPD polymorphisms: effects on DNA repair proficiency

2000 • 436 citations

Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders

1996 • 399 citations

Molecular pathogenesis of Fanconi anemia: recent progress

2006 • 377 citations

A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility.

1996 • 360 citations

Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4

1998 • 348 citations

Association of CYP 3 A 4 genotype with treatment-related leukemia

1998 • 315 citations

NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.

1992 • 313 citations

Human xeroderma pigmentosum group D gene encodes a DMA helicase

1993 • 310 citations

Functional significance of different human CYPlAl genotypes

1994 • 308 citations

Interindividual Differences in Hepatic Expression of CYP3A4: Relationship to Genetic Polymorphism in the 5′-Upstream Regulatory Region

1999 • 302 citations

Prevalence of the Inactivating 609C→T Polymorphism in the NAD(P)H:Quinone Oxidoreductase (NQO1) Gene in Patients With Primary and Therapy-Related Myeloid Leukemia

1999 • 299 citations

DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes in vitro

1998 • 290 citations

Karyotype is an independent prognostic parameter in therapy-related acute myeloid leukemia (t-AML): an analysis of 93 patients with t-AML in comparison to 1091 patients with de novo AML

2003 • 284 citations

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes.

1990 • 263 citations

Polymorphism in glutathione S -transferase P1 is associated with susceptibility to chemotherapy-induced leukemia

2001 • 258 citations

Functional characterization of polymorphisms in DNA repair genes using cytogenetic challenge assays.

2003 • 256 citations

Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene.

1995 • 256 citations

Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA

2003 • 252 citations

Xrcc3 Is Required for Assembly of Rad51 Complexes in Vivo

1998 • 251 citations

Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage.

1996 • 250 citations

Gene deletion of glutathione S-transferase theta: correlation with induced genetic damage and potential role in endogenous mutagenesis.

1995 • 241 citations

Genotype-phenotype relationships in studies of a polymorphism in NAD(P)H

1999 • 238 citations

From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity

2003 • 197 citations

Microsatellite instability and p53 mutations in therapy-related leukemia suggest mutator phenotype

1996 • 196 citations

Polycyclic aromatic hydrocarbon-DNA adducts in human lung and cancer susceptibility genes.

1993 • 187 citations

Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia.

2000 • 187 citations

Structure-activity relationships and thermal stability of human glutathione transferase P1-1 governed by the H-site residue 105

1998 • 187 citations

Rapid assessment of repair of ultraviolet DNA damage with a modified host-cell reactivation assay using a luciferase reporter gene and correlation with polymorphisms of DNA repair genes in normal human lymphocytes

2002 • 182 citations

Correlation between acetylator phenotypes and genotypes of polymorphic arylamine N-acetyltransferase in human liver.

1990 • 182 citations

The genotype distribution of the XRCC1gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia

2002 • 175 citations

Central Role for the XRCC1 BRCT I Domain in Mammalian DNA Single-Strand Break Repair

2002 • 174 citations

A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity

1999 • 160 citations

Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation

2004 • 160 citations

Polymorphisms in Genes Involved in Homologous Recombination Repair Interact to Increase the Risk of Developing Acute Myeloid Leukemia

2004 • 159 citations

The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction.

2002 • 156 citations

A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers.

2001 • 152 citations

Characterization of purified human recombinant cytochrome P4501A1-Ile462 and -Val462: assessment of a role for the rare allele in carcinogenesis.

1996 • 146 citations

Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children

2002 • 141 citations

The CYP3A4*1B polymorphism has no functional significance and is not associated with risk of breast or ovarian cancer

2002 • 141 citations

Alternative genetic pathways and cooperating genetic abnormalities in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemia

2006 • 141 citations

Differential metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 variants

2001 • 133 citations

Human glutathione S-transferase deficiency as a marker of susceptibility to epoxide-induced cytogenetic damage.

1990 • 131 citations

Functional significance of XPD polymorphic variants: attenuated apoptosis in human lymphoblastoid cells with the XPD 312 Asp/Asp genotype.

2001 • 130 citations

Negative prognostic value of glutathione S-transferase(GSTM1 and GSTT1) deletions in adult acute myeloid leukemia

2002 • 122 citations

In VitroKinetics of Two HumanCYP1A1Variant Enzymes Suggested to Be Associated with Interindividual Differences in Cancer Susceptibility

1997 • 120 citations

PCR detection of an A/G polymorphism within exon 7 of the CYP1A1 gene

1991 • 117 citations

Characterisation of the promoter region of the human DNA-repair gene Rad51.

2005 • 116 citations

Microsatellite Instability and p53 Mutations Are Associated With Abnormal Expression of the MSH2 Gene in Adult Acute Leukemia

1999 • 115 citations

Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy

2004 • 113 citations

Polymorphisms in the human XPD (ERCC2) gene, DNA repair capacity and cancer susceptibility: An appraisal

2005 • 111 citations

Variant XRCC3 implicated in cancer is functional in homology-directed repair of double-strand breaks

2002 • 110 citations

Genomic sequence comparison of the human and mouse XRCC1 DNA repair gene regions

1995 • 102 citations

Overexpression of human RAD51 and RAD52 reduces double-strand break-induced homologous recombination in mammalian cells

2001 • 102 citations

Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system.

2001 • 101 citations

Repair of oxidative DNA damage: assessing its contribution to cancer prevention

2002 • 101 citations

Genetic polymorphisms in CYP3A5, CYP3A4 and NQO1 in children who developed therapy-related myeloid malignancies

2002 • 100 citations

A germline substitution in the human MSH2 gene is associated with high-grade dysplasia and cancer in ulcerative colitis

1995 • 91 citations

Monosomy 7 myelodysplastic syndrome and other second malignant neoplasms in children with neurofibromatosis type 1.

1997 • 91 citations

Association of CYP1A1 Polymorphisms with Differential Metabolic Activation of 17β-Estradiol and Estrone

2005 • 86 citations

Human mismatch repair, drug-induced DNA damage, and secondary cancer

2003 • 83 citations

Increased DNA alterations in atherosclerotic lesions of individuals lacking the GSTM1 genotype

2001 • 82 citations

Therapy-related leukemia: clinical characteristics and analysis of new molecular risk factors in 96 adult patients

2005 • 82 citations

An intron splice acceptor polymorphism in hMSH2 and risk of leukemia after treatment with chemotherapeutic alkylating agents.

2003 • 80 citations

Monosomy 7 myelodysplastic syndrome and other second malignant neoplasms in children with neurofibromatosis type 1

1997 • 78 citations

Profile of polymorphisms of drug‐metabolising enzymes and the risk of therapy‐related leukaemia

2007 • 78 citations

Polymorphisms of CYP1A1 and glutathione S-transferase and susceptibility to adult acute myeloid leukemia.

2004 • 77 citations

Glutathione S-transferase genotypes in children who develop treatment-related acute myeloid malignancies

2000 • 74 citations

Distinct genetic involvement of the TP53 gene in therapy-related leukemia and myelodysplasia with chromosomal losses of Nos 5 and/or 7 and its possible relationship to replication error phenotype

1999 • 74 citations

Reduced BRCA1 expression due to promoter hypermethylation in therapy-related acute myeloid leukaemia

2006 • 73 citations

Msp-1 polymorphism detected with a cDNA probe for the P-450 I family on chromosome 15

1987 • 72 citations

Modulation of DNA adduct levels in human mononuclear white blood cells and granulocytes by CYP1A1, CYP2D6 and GSTM1 genetic polymorphisms

1998 • 71 citations

Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity

2006 • 64 citations

Five polymorphisms in the coding sequence of the xeroderma pigmentosum group D gene

1996 • 62 citations

Risk assessment: the importance of genetic polymorphisms in man

2001 • 60 citations

Increased risk for therapy-associated hematologic malignancies in patients with carcinoma of the breast and combined homozygous gene deletions of glutathione transferases M1 and T1

2002 • 60 citations

Genotype of glutathione S-transferase and other genetic configurations in myelodysplasia

1999 • 58 citations

Myeloid Malignancies Induced by Alkylating Agents in Nf1 Mice

1999 • 58 citations

Glutathione S-transferase theta 1 gene deletion and risk of acute myeloid leukemia.

2000 • 58 citations

Methylation of the hMLH1 promoter and its association with microsatellite instability in acute myeloid leukemia

2003 • 54 citations

High level of microsatellite instability but not hypermethylation of mismatch repair genes in therapy‐related and secondary acute myeloid leukaemia and myelodysplastic syndrome

2002 • 53 citations

Polymorphisms in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia

2006 • 52 citations

Drug treatment in the development of mismatch repair defective acute leukemia and myelodysplastic syndrome

2003 • 52 citations

Microsatellite instability occurs in defined subsets of patients with acute myeloblastic leukaemia

2001 • 50 citations

A diverged homeobox gene is involved in the proliferation and lineage commitment of human hematopoietic progenitors and highly expressed in acute myelogenous leukemia

1992 • 41 citations

An intronic germline transition in the HNPCC gene hMSH2 is associated with sporadic colorectal cancer

1997 • 41 citations

Clonal haemopoiesis may occur after conventional chemotherapy and is associated with accelerated telomere shortening and defects in the NQO1 pathway; possible mechanisms leading to an increased risk of t‐AML/MDS

2004 • 38 citations

RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia

2006 • 37 citations

Defective DNA‐mismatch repair: a potential mediator of leukemogenic susceptibility in therapy‐related myelodysplasia and leukemia

2002 • 35 citations

Deregulation of homologous recombination DNA repair in alkylating agent-treated stem cell clones: a possible role in the aetiology of chemotherapy-induced leukaemia

2005 • 26 citations

A common genetic variant in XPD associates with risk of 5q- and 7q-deleted acute myeloid leukemia

2006 • 25 citations

Stability of Microsatellites in Myeloid Neoplasias

1998 • 21 citations

Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer

2000 • 17 citations

Potential Roles for Two Human Homeodomain Containing Proteins in the Proliferation and Differentiation of Human Hematopoietic Progenitors

1993 • 15 citations

NAT2 acetylator genotypes confer no effect on the risk of developing adult acute leukemia: a case-control study.

2001 • 11 citations

Genomic Structure, Promoter Sequence, and Revised Translation of Human Homeobox Gene HLX1

1994 • 10 citations

Predisposition to therapy-related acute leukemia with balanced chromosomal translocations does not result from a major constitutive defect in DNA double-strand break end joining

2006 • 9 citations