Association of CYP 3 A 4 genotype with treatment-related leukemia

The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

1995 • 3,492 citations

REPAIR OF OXIDATIVE DAMAGE TO DNA: Enzymology and Biology

1994 • 1,435 citations

The Human Hepatic Cytochromes P450 Involved in Drug Metabolism

1992 • 932 citations

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

1992 • 850 citations

DNA glycosylases in the base excision repair of DNA

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Molecular origin of cancer: Catechol estrogen-3,4-quinones as endogenous tumor initiators

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Acute Myeloid Leukemia in Children Treated with Epipodophyllotoxins for Acute Lymphoblastic Leukemia

1991 • 723 citations

Homology-directed repair is a major double-strand break repair pathway in mammalian cells

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Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.

1993 • 536 citations

Second malignant neoplasms in children: an update from the Late Effects Study Group.

1985 • 488 citations

RESPONSE: Re: Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4

1999 • 478 citations

Substrates of human hepatic cytochrome P450 3A4

1995 • 363 citations

Leukemia After Therapy With Alkylating Agents for Childhood Cancer2

1987 • 356 citations

Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4

1998 • 348 citations

AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia

1995 • 346 citations

Cytochrome P4503A (CYP3A) metabolism: Prediction ofIn Vivo activity in humans

1996 • 308 citations

Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect

1996 • 301 citations

Homozygous Inactivation of theNF1Gene in Bone Marrow Cells from Children with Neurofibromatosis Type 1 and Malignant Myeloid Disorders

1997 • 292 citations

Mechanism of Action of Antitumor Drug Etoposide: A Review

1988 • 291 citations

Secondary Leukemia or Myelodysplastic Syndrome After Treatment With Epipodophyllotoxins

1999 • 287 citations

Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility-a review

1995 • 277 citations

Second cancers following pediatric Hodgkin's disease.

1998 • 274 citations

Secondary acute myeloid leukemia in children with acute lymphoblastic leukemia treated with etoposide.

1993 • 269 citations

Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites

1996 • 242 citations

Metabolic Polymorphisms and Cancer Susceptibility

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Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung

1987 • 233 citations

Epipodophyllotoxins, alkylating agents, and radiation and risk of secondary leukaemia after childhood cancer.

1992 • 229 citations

Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic of myelodysplasia and leukemia following therapy with cytostatic agents targeting at DNA-topoisomerase II [letter]

1991 • 210 citations

Gene structure of CYP3A4, an adult‐specific form of cytochrome P450 in human livers, and its transcriptional control

1993 • 208 citations

Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung

1987 • 204 citations

When good enzymes go bad: Conversion of topoisomerase II to a cellular toxin by antineoplastic drugs

1993 • 203 citations

Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia

1998 • 192 citations

Variability in human cytochrome P450 paclitaxel metabolism.

1995 • 186 citations

Therapy-related acute myeloid leukemia with t(8;21), inv(16), and t(8;16): a report on 25 cases and review of the literature.

1993 • 178 citations

O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4.

1994 • 175 citations

HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities [see comments]

1993 • 166 citations

t(11;22)(q23;q11.2) in acute myeloid leukemia of infant twins fuses MLL with hCDC rel , a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes

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Studies on the Catalytic Mechanism of Five DNA Glycosylases

1995 • 142 citations

Second malignant neoplasms among long-term survivors of ovarian cancer.

1996 • 139 citations

ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children

1995 • 137 citations

Spontaneous DNA Lesions Poison Human Topoisomerase IIα and Stimulate Cleavage Proximal to Leukemic 11q23 Chromosomal Breakpoints

1997 • 119 citations

Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide

1994 • 116 citations

Characterization of an allelic variant in the nifedipine-specific element of CYP3A4: ethnic distribution and implications for prostate cancer risk. Mutations in brief no. 191. Online.

1998 • 112 citations

What Structural Features Determine Repair Enzyme Specificity and Mechanism in Chemically Modified DNA?

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Myeloid neoplasia in children treated for solid tumours

1990 • 108 citations

Relationship between the debrisoquine hydroxylase polymorphism and cancer susceptibility

1992 • 108 citations

Therapy-related acute promyelocytic leukemia: a report on 16 cases.

1992 • 108 citations

Abasic Sites Stimulate Double-stranded DNA Cleavage Mediated by Topoisomerase II

1995 • 105 citations

Apurinic Sites Are Position-specific Topoisomerase II Poisons

1997 • 99 citations

Characterization of immunoglobulin and T-cell receptor gene patterns in B-cell precursor acute lymphoblastic leukemia of childhood.

1990 • 94 citations

Monosomy 7 myelodysplastic syndrome and other second malignant neoplasms in children with neurofibromatosis type 1.

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The p53 gene in pediatric therapy-related leukemia and myelodysplasia

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Monosomy 7 myelodysplastic syndrome and other second malignant neoplasms in children with neurofibromatosis type 1

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Human cytochrome P450 metabolism of teniposide and etoposide.

1992 • 74 citations

Radiotherapy- and chemotherapy-induced myelodysplasia and acute myeloid leukemia. A review

1992 • 68 citations

Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias

1997 • 67 citations

Chemotherapy-related – and late occurring – Philadelphia chromosome in AML, ALL and CML. Similar events related to treatment with DNA topoisomerase II inhibitors?

1997 • 67 citations

Assignment of the human cytochrome P-450 nifedipine oxidase gene (CYP3A4) to chromosome 7 at band q22.1 by fluorescencein situ hybridization

1992 • 63 citations

Spontaneous DNA Damage Stimulates Topoisomerase II-mediated DNA Cleavage

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Changing patterns of care in the management of anemia.

1992 • 57 citations

Common region of ALL-1 gene disrupted in epipodophyllotoxin-related secondary acute myeloid leukemia.

1993 • 46 citations

Cancer registration in Connecticut and the study of multiple primary cancers, 1935-82.

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MLL Genomic Breakpoint Distribution Within the Breakpoint Cluster Region in De Novo Leukemia in Children

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Panhandle Polymerase Chain Reaction Amplifies MLL Genomic Translocation Breakpoint Involving Unknown Partner Gene

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Second Cancer Following Chemotherapy and Radiotherapy: An epidemiological perspective

1990 • 31 citations

Role of the semi-quinone free radical of the anti-tumour agent etoposide (VP-16-213) in the inactivation of single- and double-stranded ΦX174 DNA

1990 • 31 citations

Etoposide pharmacology.

1992 • 31 citations

Emergence of secondary acute leukemia in a patient treated for osteosarcoma: implications of germline TP53 mutations

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Characterization of tumor cell resistance to 4'-deoxy-4'-iododoxorubicin developed in Ehrlich ascites cells in vivo.

1992 • 18 citations